Personalized Therapy and Clinical Advances for Congenital Heart Disease

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 30 May 2025 | Viewed by 1177

Special Issue Editor


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Guest Editor
Department of Cardiology, Complejo Hospitalario Universitario Insular-Materno Infantil, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain
Interests: congenital heart disease; pulmonary arterial hypertension; complexity; cyanosis
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Special Issue Information

Dear Colleagues,

Congenital heart disease is the most common of all congenital defects, and patients with this disease have markedly benefited from advances in medicine and surgery over recent decades, with most of them reaching adulthood. Due to the peculiarities of patients with congenital heart disease, including hospital admissions, surgery, interventional procedures, device implantation, etc., it is of special interest to guide them in a targeted manner.

Personalized therapy provides medical care to treat patients and includes genetics, inheritance, biochemical and behavioral aspects, and lifestyle, providing information on morbimortality and determining the right treatment for the right patient at the right time. Also, artificial intelligence developments in the form of new and emerging technologies and the analysis of large data collections may identify factors that discriminate groups of individuals that might benefit from different interventions. Identifying the best approach to personalized medicine requires the ability to interpret detailed patient data together with broader aspects to track and differentiate between sick and relatively healthy individuals even among those with congenital heart disease.

As personalized medicine is a medical model that aims to provide tailor-made prevention and treatment strategies and considering the great heterogenicity seen among the different types of congenital heart diseases, it is of paramount importance to obtain tools that help us to focus on the right direction.

Dr. Efrén Martínez-Quintana
Guest Editor

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Keywords

  • congenital heart disease
  • genetics
  • inheritance
  • biochemical
  • behavioral
  • lifestyle
  • artificial intelligence

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Published Papers (1 paper)

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Research

13 pages, 697 KiB  
Article
Risk Factors for Chronic Kidney Disease in Adult Patients with Congenital Heart Disease and Its Relationship with Cardiovascular Mortality
by Efrén Martínez-Quintana and Fayna Rodríguez-González
J. Clin. Med. 2024, 13(22), 6963; https://doi.org/10.3390/jcm13226963 - 19 Nov 2024
Viewed by 828
Abstract
Background: Patients with congenital heart disease (CHD) show risk factors for chronic kidney disease (CKD) and it is well known that CKD has a large negative impact on survival. Methods: Observational and prospective cohort study. Adult CHD patients and controls were [...] Read more.
Background: Patients with congenital heart disease (CHD) show risk factors for chronic kidney disease (CKD) and it is well known that CKD has a large negative impact on survival. Methods: Observational and prospective cohort study. Adult CHD patients and controls were matched for age and sex. Results: A total of 657 CHD adult patients (cases) and 1954 controls were studied. Median age in CHD patients was 30 (17–62) years and 373 (57%) were male. The prevalence of CKD (Glomerular filtration rate (GFR) < 60 mL/min/1.73 m2) was 0.2% and 4.5% in the control and CHD groups, respectively. Binary logistic regression analysis determined as risk factors for CKD in CHD patients: age [1.54 (1.04–1.28), p = 0.009], dyslipidemia [19.8 (1.35–301.1), p = 0.031], low iron concentration [0.96 (0.96–0.93), p = 0.048], cyanosis [25.7 (1.60–411.8), p = 0.022], and Down syndrome [46.8 (8.09–2710), p = 0.003]. During a follow-up time of 6.8 (1.2–10.5) years, cardiovascular mortality occurred in 31 patients with CHD showing, through the Kaplan–Meier test, a worse outcome among patients with CKD (p < 0.05) as was also seen in the univariate Cox regression survival analysis. However, after adjusting for other variables, this significance was lost, with age remaining as the unique independent prognostic factor. Conclusions: The prevalence of CKD was much higher in patients with CHD than in the control group; age, cyanosis, and Down syndrome were the predictors of a higher risk of CKD among CHD patients. Although CKD was associated with worse survival in CHD patients, only age was identified as an independent prognostic factor for cardiovascular mortality. Full article
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