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Lung Transplantation: Current Progress and Future Directions

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Respiratory Medicine".

Deadline for manuscript submissions: closed (29 April 2025) | Viewed by 627

Special Issue Editor

Division of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea
Interests: lung transplantation; pulmonary fibrosis; chronic lung allograft dysfunction; respiratory failure; bronchiolitis obliterans syndrome

Special Issue Information

Dear Colleagues,

The Special Issue "Lung Transplantation: Current Progress and Future Directions" offers a comprehensive overview of recent advancements and emerging trends in lung transplantation. It highlights significant progress in surgical techniques, immunosuppressive therapies, and patient management strategies that have enhanced outcomes and improved survival rates.

Key topics include innovations in organ preservation, personalized medicine, and novel biomarkers for the effective monitoring and prediction of transplant success. This Special Issue also addresses ongoing challenges such as managing transplant rejection and chronic lung allograft dysfunction. Notably, it discusses the integration of artificial intelligence (AI) and machine learning for enhancing clinical decision-making, optimizing donor–recipient matching, and improving post-transplant care. Future directions highlighted include potential breakthroughs in regenerative medicine, technological advancements in transplantation, the development of new technologies to optimize donor–recipient matching, and post-transplant care.

Dr. Hye Ju Yeo
Guest Editor

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Keywords

  • lung transplantation
  • surgical techniques
  • immunosuppressive therapies
  • organ preservation
  • biomarkers
  • artificial intelligence
  • machine learning
  • regenerative medicine

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Published Papers (1 paper)

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Research

11 pages, 3000 KiB  
Article
Temperature Dynamics of Porcine and Human Lungs During Static Ice Storage: Ice Is Not 4 °C
by Ismail Cenik, Jan Van Slambrouck, Annalisa Barbarossa, Xin Jin, An-Lies Provoost, Pratik Patel, Lucas Churchill, Ben Bulka, John Haney and Laurens J. Ceulemans
J. Clin. Med. 2025, 14(6), 2127; https://doi.org/10.3390/jcm14062127 - 20 Mar 2025
Viewed by 279
Abstract
Background: Static ice storage (SIS) has long been accepted as the conventional lung preservation method, assuming to maintain 4 °C temperature. Although never directly confirmed by temperature measurements, this assumption has been widely accepted. We aimed to measure lung and preservation temperature [...] Read more.
Background: Static ice storage (SIS) has long been accepted as the conventional lung preservation method, assuming to maintain 4 °C temperature. Although never directly confirmed by temperature measurements, this assumption has been widely accepted. We aimed to measure lung and preservation temperature with SIS in porcine experiments and clinical observations. Methods: Porcine lungs were preserved with SIS for 8 h (group I, n = 3) and 3 h followed by 10 °C storage (group II, n = 3). Tissue (tissueT°), first bag preservation solution (psT°) and second bag saline (salineT°) temperature were monitored. In clinical lungs (n = 4), psT° was monitored during SIS. Surface (surfaceT°) and core (coreT°) temperature were assessed before and after SIS (n = 62). Results: After 4 h in porcine lung group I, average tissueT° was 0.66 °C, psT° was 0.12 °C and salineT° was −0.02 °C. After 3 h in group II, average tissueT° was 1.90 °C, psT° was 0.57 °C and salineT° was 2.33 °C. In clinical observations, psT° was below 4 °C after 9–13 min and 0 °C after 78–267 min. After SIS, median surfaceT° was 1.25 °C (min-max; −3.2–9.2 °C) and coreT° was 1.45 °C (−0.4–4.8 °C). Conclusions: SIS leads to rapid temperature drops below 4 °C, approaching 0 °C within 2–4 h. The post-SIS lung temperature shows considerable variability and does not consistently remain at the commonly assumed 4 °C, posing potential freezing injury to donor lungs. Full article
(This article belongs to the Special Issue Lung Transplantation: Current Progress and Future Directions)
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