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Future Directions in Imaging-Guided Glaucoma Diagnosis and Therapy
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Future Directions in Imaging-Guided Glaucoma Diagnosis and Therapy

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 1227

Special Issue Editor

Dr. Takuhei Shoji

E-Mail Website
Guest Editor
1. Department of Ophthalmology, Saitama Medical University, Saitama, Japan
2. Koedo Eye Institute, Saitama, Japan
Interests: glaucoma; imaging; myopia; optical coherence tomography; optical coherence tomography angiography; visual field; visual field testing; structure-function relationship in the visual pathway disorders in glaucoma and myopia; glaucoma surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

"Future Directions in Imaging-Guided Glaucoma Diagnosis and Therapy" explores the evolving role of advanced imaging technologies in diagnosing, monitoring, and treating glaucoma. With the advent of Optical Coherence Tomography (OCT) and its angiography variant (OCTA), clinicians can now visualize the retina and optic nerve head with unprecedented detail, allowing for earlier detection of glaucomatous changes. The future of glaucoma therapy lies in integrating these imaging tools into personalized treatment plans. By correlating structural changes detected by imaging with functional outcomes, such as visual field testing, clinicians can refine therapeutic strategies to prevent disease progression more effectively. Moreover, imaging-guided interventions, including laser therapies and minimally invasive glaucoma surgeries (MIGSs), are expected to become more precise and tailored to individual patient needs. This Special Issue will review the latest advancements in imaging technology and their applications in glaucoma management, highlighting potential future directions that may revolutionize how we approach this complex and potentially blinding disease.

Dr. Takuhei Shoji
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • optical coherence tomography
  • optical coherence tomography angiography
  • visual field testing
  • glaucoma surgery
  • MIGS
  • structure–function relationship in glaucoma

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Published Papers (1 paper)

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Research

19 pages, 11813 KiB  
Article
Effects of Anatomical Variation on Ganglion Cell and Nerve Fibre Layer Evaluation by Optical Coherence Tomography
by Sami Dabbah, Jakob Bjerager, Mohamed Belmouhand, Simon P. Rothenbuehler, Inger Christine Munch, Miriam Kolko and Michael Larsen
J. Clin. Med. 2024, 13(23), 7193; https://doi.org/10.3390/jcm13237193 - 27 Nov 2024
Viewed by 940
Abstract
Background/Objectives: The automated analyses of optical coherence tomography (OCT) scans of the retina occasionally suggest the presence of tissue deficits when no visual field defects can be detected. This study was made to find the sources of such alerts. Methods: Data from [...] Read more.
Background/Objectives: The automated analyses of optical coherence tomography (OCT) scans of the retina occasionally suggest the presence of tissue deficits when no visual field defects can be detected. This study was made to find the sources of such alerts. Methods: Data from a population-based cohort of 360 participants aged 30–80 years was analysed for the anatomical sources of alerts after the extensive exclusion of participants where any suspicion of abnormality could be raised. An analysis was made of 12 × 9 mm volume scans centred between the disc and the fovea. The exclusions comprised 107 eyes with definite or borderline abnormal visual fields or other potentially confounding characteristics. A statistical analysis of the thickness patterns was made using the manufacturer’s proprietary algorithm. The analysis comprised alerts corresponding to local layer thickness values in the lower 5th percentile of an independent reference population. Results: Of the 613 eligible healthy eyes, thickness deficit alerts were seen in 391. They were related to the angle between the temporal nerve fibre ridges being wider, narrower, or rotated compared to the reference template in 174 eyes and to the variations in the size of the macula in 207 eyes. The source was unidentifiable in 28 eyes. The common sources were a thin papillomacular nerve fibre layer accompanied by arcuate nerve fibre ridges spaced far apart and a thinly, but wider than the normal macular ganglion cell layer. Conclusions: Anatomical variation in the retinal nerve fibre and ganglion cell layers was the source of more than 90% of the thickness deficit alerts in the eyes with normal visual fields. Full article
(This article belongs to the Special Issue Future Directions in Imaging-Guided Glaucoma Diagnosis and Therapy)
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