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Clinical Neurophysiology: New Perspective
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Clinical Neurophysiology: New Perspective

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: closed (20 December 2024) | Viewed by 2495

Special Issue Editor

Dr. Daniele Coraci

E-Mail Website
Guest Editor
Department of Neuroscience, Secrtion of Rehabilitation, University of Padova, Via VIII Febbraio 2, 35122 Padua, Italy
Interests: rehabilitation; nerve; muscle; electrophysiology; ultrasound; gait analysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Clinical neurophysiology includes a large number of examinations that can study the function of and quantify the damage to the nervous system. These tests are extremely useful to support the diagnosis of many diseases of neurological and rehabilitation interest. Additionally, clinical neurophysiology can assist the general management of a patient, providing important information about the disease evolution and the response to the therapy. Finally, it can be applied to study patients affected by diseases not directly related to the nervous system. Aside from these, intraoperative monitoring represents another important field of neurophysiological application to support the delicate surgical interventions involving the brain and the spine.

The current Special Issue aims to explore clinical neurophysiology from different points of view from a cellular basis to rehabilitation, with a specific interest in recent innovations, including new technical procedures, new applications, automatizations, and integration with other examinations.

Different types of papers (reviews, trials, case reports) are welcome for this Special Issue. We ask for the authors to submit papers about human subjects that deal with the clinical applications of different neurophysiological examinations. We encourage the submission of papers concerning the use of neurophysiological tests for the diagnosis, prognosis, and treatment of diseases involving different human systems.

The following topics are suggested:

  • History of clinical neurophysiology with a specific focus on new developments;
  • Physiological basis of neurophysiological tests;
  • Limitations and evolution of clinical neurophysiology;
  • Evaluation of pain and autonomous nervous system;
  • Clinical neurophysiology in central nervous system diseases;
  • Clinical neurophysiology in peripheral nervous system diseases;
  • Clinical neurophysiology in myopathies;
  • Clinical neurophysiology in orthopedic and rheumatologic diseases;
  • Clinical neurophysiology and oncology;
  • Clinical neurophysiology and cardiopulmonary disability;
  • Clinical neurophysiology and rehabilitation;
  • Utility of clinical neurophysiology to guide therapeutic decisions;
  • Treatment based on neurophysiological techniques;
  • Association with other medical techniques (imaging, lab tests, biopsy, etc.);
  • Neurophysiological examination in pediatric populations;
  • Neurophysiological examination in geriatric populations.

Dr. Daniele Coraci
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurophysiology
  • diagnosis
  • treatment
  • rehabilitation
  • outcome measures

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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11 pages, 1172 KiB  
Article
Reverse Split Hand as a Neurophysiological Hallmark of Spinal Muscular Atrophy
by Veria Vacchiano, Francesca Morabito, Luigi Bonan, Luca Teodorani, Claudia Faini, Giovanni Rizzo and Rocco Liguori
J. Clin. Med. 2024, 13(22), 6881; https://doi.org/10.3390/jcm13226881 - 15 Nov 2024
Viewed by 950
Abstract
Objective: Motor unit number estimation (MUNE) methods are crucial for estimating lower motor neuron loss in motor neuron diseases. The MScanFit MUNE (MScanFit) is a novel method that estimates MUNE values from compound motor action potential (CMAP) scans, demonstrating high sensitivity and reproducibility [...] Read more.
Objective: Motor unit number estimation (MUNE) methods are crucial for estimating lower motor neuron loss in motor neuron diseases. The MScanFit MUNE (MScanFit) is a novel method that estimates MUNE values from compound motor action potential (CMAP) scans, demonstrating high sensitivity and reproducibility in detecting motor unit loss in amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). In this study, we aimed to characterize the pattern of motor unit loss in the hand intrinsic muscles of SMA patients compared to ALS patients and healthy controls (HC) using MScanFit MUNE. Methods: Patients diagnosed with ALS, adult SMA patients, and HC were prospectively enrolled. MScanFit examinations were performed on the abductor pollicis brevis (APB) and abductor digiti minimi (ADM) muscles. To focus on the different patterns of motor neuron degeneration in the intrinsic hand muscles, the ratio of CMAP amplitude of APB to ADM (CMAP ratio) and the ratio of MUNE values of APB to those of the ADM muscle (MUNE ratio) were calculated. Results: The study included 46 ALS patients, 16 SMA patients, and 23 HC. MScanFit MUNE revealed distinct patterns of motor unit degeneration in SMA patients, notably more severe in the ADM than in the APB muscle, indicating a “reverse” split-hand phenomenon. Both CMAP and MUNE ratios demonstrated high diagnostic accuracy in distinguishing ALS from SMA, with the MUNE ratio performing better. Conclusions: MScanFit MUNE is a valuable tool for exploring distinct patterns of motor neuron degeneration in patients with different types of motor neuron diseases. Full article
(This article belongs to the Special Issue Clinical Neurophysiology: New Perspective)
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6 pages, 1600 KiB  
Case Report
Unusual Symptoms of Lacertus Syndrome: A Case Report
by Bartosz Chlebanowski, Paweł Walkowiak, Emilia Czupryniak, Marcin Domżalski and Justyna Pigońska
J. Clin. Med. 2025, 14(3), 685; https://doi.org/10.3390/jcm14030685 - 22 Jan 2025
Viewed by 1045
Abstract
Background: Lacertus syndrome, a condition characterized by median nerve compression at the elbow due to anatomical variations, is often misdiagnosed. This case report describes a 53-year-old female patient who presented with severe lateral elbow and shoulder pain, previously diagnosed with cervicalgia and tennis [...] Read more.
Background: Lacertus syndrome, a condition characterized by median nerve compression at the elbow due to anatomical variations, is often misdiagnosed. This case report describes a 53-year-old female patient who presented with severe lateral elbow and shoulder pain, previously diagnosed with cervicalgia and tennis elbow. Methods: Upon admission, she reported significant pain (NRS—Numerical Rating Scale 8/10) and occasional radiating paresthesia in the first three digits of her left hand. Clinical examination revealed weakness in the wrist and finger flexion, which was exacerbated by a positive Cutaneous Scratch Test (CST), while Magnetic Resonance Imaging (MRI) of the cervical spine showed no definitive abnormalities. Electroneurography (ENG) indicated reduced amplitude in the left anterior interosseous nerve. Ultrasound excluded carpal tunnel syndrome but identified nerve flattening beneath the pronator teres muscle. A surgical decompression of the median nerve was performed, resulting in immediate improvement in muscle strength and significant pain reduction (NRS 1/10) postoperatively. Follow-up evaluations confirmed substantial recovery in nerve function and morphology. Conclusions: This case illustrates the atypical presentation of Lacertus syndrome, emphasizing the need for comprehensive diagnostic approaches that include clinical, imaging, and neurophysiological assessments. Awareness of this syndrome is crucial for differential diagnosis in patients exhibiting uncharacteristic symptoms, such as shoulder or elbow pain, to ensure timely and effective treatment. Full article
(This article belongs to the Special Issue Clinical Neurophysiology: New Perspective)
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