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Past, Present, and Future in Microsurgical Treatment of Lymphedema

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine".

Deadline for manuscript submissions: closed (18 October 2024) | Viewed by 2848

Special Issue Editor


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Guest Editor
Department of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Interests: plastic surgery; lymphedema surgery; lymphovenous bypass; vascularized lymph node transfer; immediate lymphatic reconstruction

Special Issue Information

Dear Colleagues,

The field of lymphedema surgery has witnessed tremendous advances over the years with the growth of two workhorse techniques and introduction of novel and combined approaches. The use of the lymphovenous bypass (LVB), along with vascularized lymph node transfer (VLNT), represents the primary means for treatment of lymphedema; however, combining the two techniques and the introduction of vascularized lymph tissue or lymph vessel transfer may further improve outcomes in patients suffering from lymphedema. Given the reliable and reproducible outcomes achieved using these physiologic techniques, supermicrosurgeons have begun incorporating these techniques in a prophylactic fashion in order to prevent lymphedema in high-risk patients. The concept of a lymphatic interposition flap transfer (LIFT) utilizes the native lymphatic architecture contained within a vascularized free tissue transfer to provide soft tissue coverage for limb salvage while simultaneously reconstructing and restoring the lymphatic drainage from the limb. This mirrors the concept of immediate lymphatic reconstruction (ILR), where the LVB technique is employed at the time of regional node dissection. This is now rapidly becoming the standard of care for breast cancer patients who undergo an axillary node dissection (AND). At the time of the AND, lymphatic channels that are ligated during the dissection are then secondarily repaired during the same operation to preserve the lymphatic drainage from the arm. Thus, this Special Issue aims to provide a comprehensive overview of these approaches from a historic perspective, their maturation and evolution, and the future of lymphedema surgery from world-renowned experts in the field.

Dr. Edward I. Chang
Guest Editor

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Keywords

  • lymphedema surgery
  • lymphovenous bypass
  • vascularized lymph node transfer
  • immediate lymphatic reconstruction

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Published Papers (2 papers)

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Research

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14 pages, 2855 KiB  
Article
Primary LYmphedema Multidisciplinary Approach in Patients Affected by Primary Lower Extremity Lymphedema
by Pedro Ciudad, Alberto Bolletta, Juste Kaciulyte, Oscar J. Manrique and Joseph M. Escandón
J. Clin. Med. 2024, 13(17), 5161; https://doi.org/10.3390/jcm13175161 - 30 Aug 2024
Viewed by 1550
Abstract
Background: Primary lymphedema is a chronic condition caused by a developmental abnormality of the lymphatic system, leading to its malfunction. Various surgical options, including physiologic and excisional procedures, have been proposed. The aim of this study was to present a comprehensive algorithm [...] Read more.
Background: Primary lymphedema is a chronic condition caused by a developmental abnormality of the lymphatic system, leading to its malfunction. Various surgical options, including physiologic and excisional procedures, have been proposed. The aim of this study was to present a comprehensive algorithm for the treatment of primary lower extremity lymphedema: the Primary LYmphedema Multidisciplinary Approach (P-LYMA). Methods: Nineteen patients were treated following the P-LYMA protocol. Patients underwent pre- and postoperative complex decongestive therapy (CDT). A variety of physiologic and excisional procedures were performed, either independently or in combination. The primary outcome was to assess the circumferential reduction rate (CRR). The Lymphedema Quality of Life Score (LeQOLiS), reduction in the number of cellulitis episodes, and complications were recorded. Results: The mean CRR was 73 ± 20% at twelve months postoperatively. The frequency of cellulitis episodes per year decreased from a mean of 1.9 ± 0.8 preoperatively to 0.4 ± 0.6 during follow-up. Two patients experienced minor complications. The mean hospitalization time was 5 days. Patients’ quality of life, as measured by the LeQOLiS, significantly improved from 70.4 ± 12 preoperatively to 24 ± 14 at twelve months postoperatively. Conclusions: The P-LYMA algorithm maximizes surgical outcomes and improves the quality of life in patients with primary lymphedema. CDT is essential for optimizing results. Full article
(This article belongs to the Special Issue Past, Present, and Future in Microsurgical Treatment of Lymphedema)
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Review

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15 pages, 4701 KiB  
Review
The MD Anderson Algorithm for Lymphedema Management
by Ashleigh M. Francis, Noa G. Kopplin and Edward I. Chang
J. Clin. Med. 2025, 14(6), 1851; https://doi.org/10.3390/jcm14061851 - 10 Mar 2025
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Abstract
This article details the MD Anderson Cancer Center algorithm for lymphedema management. We discuss prophylaxis against and treatment options for both upper extremity and lower extremity lymphedema. Full article
(This article belongs to the Special Issue Past, Present, and Future in Microsurgical Treatment of Lymphedema)
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