Interplay of Motility, Microbiota, and Function: New Insights into GI Disorders, IBS, and SIBO

Dear Colleagues,

Gastrointestinal (GI) motility disorders represent a complex intersection of neuromuscular function, microbiota composition, and host–microbe interactions. Functional disorders such as irritable bowel syndrome (IBS) and small intestinal bacterial overgrowth (SIBO) exemplify this dynamic interplay, where alterations in motility can shape microbial ecosystems, and conversely, dysbiosis can influence motility, sensitivity, and inflammation. Despite growing recognition of these bidirectional relationships, mechanistic understanding and clinical management remain challenging.

This Special Issue of the Journal of Clinical Medicine invites original research, reviews, and clinical studies exploring the multifaceted links between GI motility, microbiota, and functional gastrointestinal disorders. Topics of interest include diagnostic innovations, motility–microbiome interactions, pathophysiological mechanisms, biomarkers, and emerging therapeutic strategies such as microbiota modulation, prokinetic agents, and dietary interventions. Submissions highlighting translational approaches or integrating motility assessment with microbial and metabolic profiling are especially encouraged.

By uniting experts across gastroenterology, microbiology, and neurogastroenterology, this Special Issue aims to advance a holistic understanding of GI dysfunction and foster new paradigms in diagnosis and personalized treatment.

Dr. Tsachi Tsadok Perets
Guest Editor

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