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Updates in Digestive Diseases and Endoscopy
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Updates in Digestive Diseases and Endoscopy

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: closed (31 May 2025) | Viewed by 9425

Special Issue Editors

Dr. Hossein Haghbin

E-Mail Website
Guest Editor
Department of Gastroenterology, Ascension Providence Southfield, Southfield, MI, USA
Interests: colonoscopy; gastroenterology; endoscopy; endoscopic retrograde cholangiopancreatography
Dr. Muhammad Aziz

E-Mail Website
Guest Editor
Division of Gastroenterology, Bon Secours Mercy Health, Toledo, OH 43608, USA
Interests: colon cancer screening; colonoscopy; esophagogastroduodenoscopy; gastrointestinal hemorrhage; inflammatory bowel disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The advancements in endoscopy during the current era are remarkable. Various diseases that have previously been difficult to diagnose or treat have become subjects of EGD, colonoscopy, ERCP, or EUS. Surgery is being replaced by auxiliary endoscopic methods like EMR and ESD in the resection of lesions with submucosal invasion. With the ever-increasing rates of obesity across the globe, endobariatric procedures are gaining popularity due to the data exhibiting excellent efficacy and safety. Artificial intelligence and many auxiliary techniques and devices used for the increasing of adenoma detection rates and the improving of the quality of colonoscopies have been major topics of discussion in recent years. Moreover, the novel developments in cholangioscopy and pancreatoscopy have opened doors to great diagnostic and therapeutic areas. Third space endoscopic techniques like POEM have replaced surgery in the treatment of achalasia, gastroparesis, and many other diseases. These topics, in addition to any topics pertaining to endoscopy in terms of efficacy, safety, cost effectiveness, innovations, reviews, etc, are highly welcome for consideration to be published in this Special Issue.

Dr. Hossein Haghbin
Dr. Muhammad Aziz
Guest Editors

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Keywords

  • colonoscopy
  • EGD
  • ERCP
  • EUS
  • endoscopic submucosal dissection (ESD)
  • endoscopic mucosal resection (EMR)
  • artificial intelligence
  • screening colonoscopy
  • pancreatoscopy
  • cholangioscopy

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Published Papers (4 papers)

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Research

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10 pages, 674 KiB  
Article
Colonic Polyp Study: Differences in Adenoma Characteristics Based on Colonoscopy History over 5-Year Follow-Up Period
by Sang Hyun Park, Kwang Il Hong, Hyun Chul Park, Young Sun Kim, Gene Hyun Bok, Kyung Ho Kim, Dong Suk Shin, Jae Yong Han, Young Kwan Kim, Yeun Jong Choi, Soo Hoon Eun, Byung Hoon Lim, Kyeong Kun Kwack and The Korean Society of Digestive Endoscopy Polyp Study
J. Clin. Med. 2025, 14(1), 194; https://doi.org/10.3390/jcm14010194 - 31 Dec 2024
Cited by 1 | Viewed by 1804
Abstract
Background: Timely detection and removal of colonic adenomas are critical for preventing colorectal cancer. Methods: This study analyzed differences in colonic adenoma characteristics based on colonoscopy history by reviewing the medical records of 14,029 patients who underwent colonoscopy between January and [...] Read more.
Background: Timely detection and removal of colonic adenomas are critical for preventing colorectal cancer. Methods: This study analyzed differences in colonic adenoma characteristics based on colonoscopy history by reviewing the medical records of 14,029 patients who underwent colonoscopy between January and June 2020 across 40 primary medical institutions in Korea. Results: Adenoma and advanced neoplasia characteristics varied significantly with colonoscopy history (p < 0.05). In the first-time colonoscopy group, adenomas were more frequent in the sigmoid colon (S-colon) and rectum, with Is features and non-granular laterally spreading tumors. Advanced neoplasia was also more common in the S-colon and rectum, with Is and advanced-type features. In the <5-year group, adenomas were predominantly found in the transverse colon (T-colon) and descending colon (D-colon), with IIa and IIb features. Advanced neoplasia in this group was more frequent in the cecum and T-colon, with IIa and IIb features and laterally spreading tumors. In the ≥5-year group, adenomas were more commonly located in the ascending colon (A-colon) and cecum, with Ip features, while advanced neoplasia was more frequent in the A-colon and D-colon, also with Ip features. Conclusions: Although every segment of the colorectum should be carefully observed regardless of colonoscopy history, these findings suggest that prioritizing specific colonic segments for examination based on colonoscopy history may improve adenoma detection rates and reduce the incidence of colorectal cancer. However, further large-scale, prospective studies are needed to confirm these findings and support their application in clinical practice. Full article
(This article belongs to the Special Issue Updates in Digestive Diseases and Endoscopy)
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14 pages, 3824 KiB  
Article
Clinical Utility of Disease Activity Indices in Predicting Short-Term Response to Biologics in Patients with Ulcerative Colitis
by Filip Romaniuk, Anna Franus, Aleksandra Sobolewska-Włodarczyk and Anita Gąsiorowska
J. Clin. Med. 2024, 13(12), 3455; https://doi.org/10.3390/jcm13123455 - 13 Jun 2024
Viewed by 1403
Abstract
Background: The Mayo Score [MS], endoscopic Mayo Score [eMS] and the Ulcerative Colitis Index of Severity [UCEIS] are employed in the assessment of ulcerative colitis [UC] severity. This study compared the aforementioned indices in terms of predictory value for response to remission [...] Read more.
Background: The Mayo Score [MS], endoscopic Mayo Score [eMS] and the Ulcerative Colitis Index of Severity [UCEIS] are employed in the assessment of ulcerative colitis [UC] severity. This study compared the aforementioned indices in terms of predictory value for response to remission induction treatment with anti-TNF and anti-integrin biologics. Methods: A total of 38 patients were retrospectively evaluated in the study, 23 male and 15 female, aged 18–74 years old who had undergone a total of 53 biological therapy courses with either infliximab [IFX] or vedolizumab [VDZ] at the Department of Gastroenterology of the Medical University of Łódź. The clinical and endoscopic activity of UC was assessed at the outset of biological therapy and the 14th week remission induction assessment juncture. Results: The study analyzed 19 IFX and 34 VDZ treatment courses. The response rate of patients receiving IFX reached 73.67% and the response rate was 58.82% for VDZ. The mean MS, eMS and UCEIS improved among all patient groups: 8.316 ± 1.974 to 4.158 ± 2.218 (p < 0.05), 2.632 ± 0.597 to 1.790 ± 0.713 (p < 0.05) and 4.790 ± 1.745 to 3.000 ± 1.453 (p < 0.05) for IFX, 7.088 ± 2.234 to 3.618 ± 2.412 (p < 0.05), 2.706 ± 0.524 to 1.677 ± 1.065 (p < 0.05) and 4.235 ± 1.350 to 2.735 ± 1.880 (p < 0.05) for VDZ. Conclusions: The outcome assessment in induction treatment of UC includes clinical data and endoscopic evaluation. Severity of inflammatory lesion activity according to the eMS and UCEIS indices correlates with the overall disease presentation as evaluated with MS. The UCEIS provides an overall better predictor for biological induction treatment when compared with the eMS in both patient groups, particularly in those receiving VDZ. It provides a promising alternative to the eMS and can be employed for both initial disease severity assessment as well as for treatment response monitoring. Full article
(This article belongs to the Special Issue Updates in Digestive Diseases and Endoscopy)
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Review

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14 pages, 1754 KiB  
Review
Efficacy of Dietary Interventions for Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis
by Hossein Haghbin, Fariha Hasan, Manesh Kumar Gangwani, Nurruddinkhodja Zakirkhodjaev, Wade Lee-Smith, Azizullah Beran, Faisal Kamal, Benjamin Hart and Muhammad Aziz
J. Clin. Med. 2024, 13(24), 7531; https://doi.org/10.3390/jcm13247531 - 11 Dec 2024
Cited by 4 | Viewed by 4205
Abstract
Introduction: Irritable bowel syndrome (IBS) is a common condition that alters the quality of life of patients. A variety of dietary interventions have been introduced to address this debilitating condition. The low-FODMAP diet (LFD), gluten-free diet (GFD), and Mediterranean diet are examples showing [...] Read more.
Introduction: Irritable bowel syndrome (IBS) is a common condition that alters the quality of life of patients. A variety of dietary interventions have been introduced to address this debilitating condition. The low-FODMAP diet (LFD), gluten-free diet (GFD), and Mediterranean diet are examples showing efficacy. The aim of this network meta-analysis was to compare these interventions to find the best approach. Methods: We performed a systematic review of the available literature through 14 March 2024 in the following databases: Embase, PubMed, MEDLINE OVID, Web of Science, CINAHL Plus, and Cochrane Central. We only included randomized controlled trials (RCTs). We used a random effects model and conducted a direct meta-analysis based on the DerSimonian–Laird approach and a network meta-analysis based on the frequentist approach. Mean differences (MDs) with 95% confidence interval (CI) were calculated. The primary outcomes included IBS quality of life (IBS QOL) and IBS symptom severity scale (IBS-SSS). Results: We finalized 23 studies including 1689 IBS patients. In the direct meta-analysis, there was no statistically significant difference in any IBS score between GFD and either LFD or standard diet. Meanwhile, the LFD was statistically superior to the standard diet in the IBS-SSS (MD: −46.29, CI: −63.72–−28.86, p < 0.01) and IBS QOL (MD: 4.06, CI: 0.72–7.41, p = 0.02). On ranking, the Mediterranean diet showed the greatest improvement in IBS-SSS, IBS-QOL, distension, dissatisfaction, and general life interference, followed by the LFD alone or in combination with the GFD. Conclusions: We demonstrated the efficacy of dietary interventions such as the LFD and Mediterranean diet in improving IBS. There is a need for large RCTs with head-to-head comparisons, particularly for the Mediterranean diet. Full article
(This article belongs to the Special Issue Updates in Digestive Diseases and Endoscopy)
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Other

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8 pages, 5721 KiB  
Case Report
Residual Recurrence of a Small Intestinal Capillary Hemangioma with Obscure Gastrointestinal Bleeding Treated by Double-Balloon Endoscopy: A Case Report and Literature Review
by Kei Nomura, Tomoyoshi Shibuya, Arisa Yuzawa, Masashi Omori, Rina Odakura, Masao Koma, Kentaro Ito, Eiji Kamba, Takafumi Maruyama, Osamu Nomura, Hirofumi Fukushima, Takashi Murakami, Kumiko Ueda, Dai Ishikawa, Mariko Hojo and Akihito Nagahara
J. Clin. Med. 2024, 13(12), 3415; https://doi.org/10.3390/jcm13123415 - 11 Jun 2024
Cited by 1 | Viewed by 1426
Abstract
An 86-year-old man presented with anemia. He underwent abdominal contrast-enhanced computed tomography, gastroscopy, and colonoscopy without any bleeding detected. Small bowel capsule endoscopy (SBCE) revealed a reddish polypoid lesion with blood oozing into the jejunum. Antegrade double-balloon endoscopy (DBE) revealed a 5 mm [...] Read more.
An 86-year-old man presented with anemia. He underwent abdominal contrast-enhanced computed tomography, gastroscopy, and colonoscopy without any bleeding detected. Small bowel capsule endoscopy (SBCE) revealed a reddish polypoid lesion with blood oozing into the jejunum. Antegrade double-balloon endoscopy (DBE) revealed a 5 mm sized protrusion into the jejunum. Endoscopic mucosal resection (EMR) was difficult; the lesion was snared and resected before energization. Clips prevented further bleeding and the lesion’s position was marked with a tattoo. Histopathological examination of the lesion led to a diagnosis of capillary hemangioma. After 11 months, the patient was again anemic. A reddish polypoid lesion oozing blood near the tattoo was found by SBCE. Another antegrade DBE showed a 7 mm sized protrusion near the tattoo. The lesion was successfully treated by EMR. Histopathological examination revealed the residual recurrence of a small intestinal capillary hemangioma. The patient recovered from anemia after the EMR. Two months later, SBCE showed no findings around the tattoo. Hemangiomas account for 7–10% of benign small intestinal tumors; most are cavernous hemangiomas, and capillary hemangiomas are rare. We report a rare case of a recurring small intestinal capillary hemangioma detected by SBCE and treated using DBE. We also review the literature. Full article
(This article belongs to the Special Issue Updates in Digestive Diseases and Endoscopy)
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