Advancements in Cardiomyopathies: Diagnosis, Treatment and Management—2nd Edition

Dear Colleagues,

It is our pleasure to warmly invite you to contribute to the second volume of the Special Issue entitled “Advancements in Cardiomyopathies: Diagnosis, Treatment and Management—2nd Edition”.

Considering the great interest generated by the first edition, where six high-quality papers were published, offering valuable insights into the evolving field of cardiomyopathies, this second edition aims to broaden and deepen scientific conversation. It will do so by collecting innovative research, cutting-edge diagnostic approaches, advances in genetic characterization, and emerging therapeutic strategies. This second volume represents an opportunity to highlight the rapid progress in cardiomyopathy research and promote interdisciplinary dialogue. It also aims to provide clinicians and researchers with updated perspectives that can support precision medicine and improve patient care.

For more details on the first volume, please visit the following link:

https://www.mdpi.com/journal/jcm/special_issues/Q52968DNH5.

Cardiomyopathies encompass a heterogeneous group of structural and functional disorders of the heart muscle that are not explained by coronary, valvular, hypertensive, or congenital disease. Genetic variants play a central role in many of these conditions, underscoring the importance of recognizing cardiomyopathies as familial diseases that can affect multiple generations. This perspective highlights the value of family screening, which enables early detection, refined risk stratification, and timely, individualized therapy.

In recent years, extraordinary progress has reshaped our understanding of cardiomyopathies. Advanced cardiovascular imaging, particularly cardiac magnetic resonance, has transformed diagnostic accuracy and phenotyping. Next-generation sequencing and precision-genetics approaches now allow clinicians to uncover pathogenic variants and decode complex genotype–phenotype relationships. Heightened attention to clinical red flags and the molecular mechanisms underpinning disease has further refined classification schemes. Notably, the recognition of non-dilated left ventricular cardiomyopathy as a distinct entity illustrates how rapidly the field is evolving.

At the same time, innovative technologies such as artificial intelligence promise to enhance diagnostic workflows and predictive modelling, while emerging disease-modifying therapies are shifting treatment paradigms across multiple cardiomyopathy subtypes. Novel biomarkers are also enabling earlier identification of high-risk patients and more tailored therapeutic strategies.

This Special Issue, entitled "Advancements in Cardiomyopathies: Diagnosis, Treatment and Management—2nd Edition," aims to deliver a comprehensive and up-to-date overview of these rapidly evolving themes. By gathering contributions from experts across diverse disciplines, we hope to foster a truly multidisciplinary dialogue and highlight the scientific and clinical advances that are redefining the diagnosis, management, and long-term care of patients with cardiomyopathies.

Dr. Cinzia Forleo
Guest Editor

Dr. Maria Cristina Carella
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.