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Clinical Advancements in Retinal Diseases
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Clinical Advancements in Retinal Diseases

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 1819

Special Issue Editors

Dr. Anna Bryl

E-Mail Website
Guest Editor
Department of Ophthalmology and Eye Rehabilitation, Medical University of Bialystok, 15-089 Bialystok, Poland
Interests: diabetic retinopathy; refractive errors; cataracts; ocular disease
Prof. Dr. Malgorzata Mrugacz

E-Mail Website
Guest Editor
Department of Ophthalmology and Eye Rehabilitation, Medical University of Bialystok, Kilinskiego 1, 15-089 Białystok, Poland
Interests: eye; dry eye disease; diabetic retinopathy; myopia; obesity; children
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, significant progress has been observed in relation to the diagnosis and treatment of retinal diseases. This progress was made possible by the development of novel imaging technologies, leading to improved outcomes for patients with retinal diseases. This Special Issue in the Journal of Clinical Medicine focuses on retinal diseases, diagnostics, and possible treatments. I hope that it will bring together experts who will discuss the latest developments in this field. The articles in this Special Issue will provide valuable information relating to recent developments in improving the diagnosis and treatment of retinal diseases.

For the publication of this Special Issue, I invite you to submit original articles and review papers on diagnoses and interventions for any retinal disorders that will serve readers in this field to better cope with patients with these pathologies.

Dr. Anna Bryl
Prof. Dr. Malgorzata Mrugacz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • retinal diseases
  • treatment of retinal diseases
  • diagnostics of retinal diseases
  • retinal imaging
  • retinal surgeries

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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15 pages, 625 KiB  
Article
Characteristics, Risks, and Prevention of Rhegmatogenous Retinal Detachment in the Contralateral Eye
by Rami Al-Dwairi, Omar Saleh, Hasan Mohidat, Seren Al Beiruti, Ali Alshami, Leen El Taani, Abdullah Sharayah, Ahmed H. Al Sharie and Abdelwahab Aleshawi
J. Clin. Med. 2025, 14(1), 222; https://doi.org/10.3390/jcm14010222 - 2 Jan 2025
Cited by 2 | Viewed by 1038
Abstract
Background/Objectives: Rhegmatogenous retinal detachment (RRD) is a potentially blinding retinal disorder. RRD in the first eye is a well-recognized risk factor for bilateral RRD since risk factors that predispose to RRD affect both eyes. In this study, we assess the presenting factors [...] Read more.
Background/Objectives: Rhegmatogenous retinal detachment (RRD) is a potentially blinding retinal disorder. RRD in the first eye is a well-recognized risk factor for bilateral RRD since risk factors that predispose to RRD affect both eyes. In this study, we assess the presenting factors that predispose individuals to bilateral RRD and evaluate the role of prophylactic retinopexy in preventing fellow-eye RRD. Methods: Retrospectively, all patients who underwent RRD repair through pars plana vitrectomy were included. A medical database was utilized to extract the data. The primary outcome was to report the development of RRD in the fellow eyes according to the presenting risk factors. Secondary outcomes included the prophylactic effect of laser retinopexy for the fellow eye. Results: In this study, 348 patients were included. The mean age of the patients was 46.3 years. Bilateral RRD was developed in 13.7% of the patients. It was found that total RRD in the first eye (p-value = 0.045), the presence of lattice degeneration in the first eye (p-value = 0.036), the presence of high-risk breaks (p-value = 0.0001) or lattice degeneration (p-value = 0.0004) in the fellow eye, the involvement of the inferior-nasal quadrant in the first eye (p-value = 0.043), and the presence of connective tissue diseases (p-value = 0.008) were significantly associated with the development of fellow-eye RRD. Performing prophylactic retinopexy was associated with a reduction in the incidence of fellow-eye RRD (with or without high-risk breaks) (p-value = 0.0001). It was not associated with a reduction in the risk of fellow-eye RRD in cases of lattice degeneration alone. Conclusions: Recognition of certain perioperative risk factors (such as high-risk retinal tears) during the presentation of first-eye RRD is crucial. Prophylactic laser retinopexy may have a critical role in preventing fellow-eye RRD. Patients’ awareness should be raised about the symptoms of RRD. Full article
(This article belongs to the Special Issue Clinical Advancements in Retinal Diseases)
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17 pages, 755 KiB  
Systematic Review
Prognostic Factors for Visual Postsurgical Outcome in Rhegmatogenous Retinal Detachment—A Systematic Review
by George Chereji, Ovidiu Samoilă and Simona Delia Nicoară
J. Clin. Med. 2025, 14(6), 2016; https://doi.org/10.3390/jcm14062016 - 16 Mar 2025
Viewed by 595
Abstract
Background: Rhegmatogenous retinal detachment (RRD) is an ophthalmological emergency that can lead to vision loss if left untreated. Pars plana vitrectomy (PPV) is the preferred procedure for most complex RRD cases with a high success rate. However, certain parameters related to the patient, [...] Read more.
Background: Rhegmatogenous retinal detachment (RRD) is an ophthalmological emergency that can lead to vision loss if left untreated. Pars plana vitrectomy (PPV) is the preferred procedure for most complex RRD cases with a high success rate. However, certain parameters related to the patient, disease history, or ocular presentation may influence surgical outcomes. Methods: A systematic review of studies from 2010 to 2023 was conducted using PubMed/Medline (National Library of Medicine, Bethesda, MD, USA) and Scopus (Elsevier, Netherlands). The main objective of this review is to present the most significant data published in the scientific literature over the last 10 years, focusing on the latest implications of prognostic factors affecting the success of PPV in RRD. The search included terms such as “prognostic factors”, “visual outcome”, “functional outcome”, and “rhegmatogenous retinal detachment”. The database search returned 3489 studies. The included studies had to involve participants with RRD treated mainly by PPV, a minimum of 10 participants, and at least a 6-month follow-up period. Studies were excluded if they involved patients with previous PPV treatment or trauma. After reviewing their abstracts, titles, and applying the exclusion criteria, 19 articles were selected. Because it is an ample and interesting topic, many authors explored the connection between prognostic factors involved in the management of RRD and the final visual and functional outcomes. Methodological quality was assessed using PRISMA guidelines. Results: various factors have been studied, ranging from classic ophthalmological parameters, such as refractive error, axial length, lens status, visual acuity, duration of symptoms, description of the RRD, and retinal tears, to more complex findings on optical coherence tomography. Conclusions: The factors that significantly influenced postoperative prognosis in RRD included preoperative best-corrected visual acuity (BCVA), duration of symptoms, macular status (on/off), extent of retinal detachment, presence of macular hole, and proliferative vitreoretinopathy (PVR). Disruption of the ellipsoid zone (EZ), presence of epiretinal membrane (ERM), and lack of external limiting membrane (ELM) integrity were associated with poorer outcomes following RRD surgery. Full article
(This article belongs to the Special Issue Clinical Advancements in Retinal Diseases)
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