Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
2.8
3.1
Journals
Inorganics
Special Issues
New Trends in Vanadium Chemistry, Biochemistry, and Medicinal Chemistry, 2nd...
share announcement

New Trends in Vanadium Chemistry, Biochemistry, and Medicinal Chemistry, 2nd Edition

A special issue of Inorganics (ISSN 2304-6740). This special issue belongs to the section "Bioinorganic Chemistry".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 594

Special Issue Editors

Prof. Dr. Dinorah Gambino

E-Mail Website
Guest Editor
Área Química Inorgánica, Facultad de Química, Universidad de la República, Montevideo, Uruguay
Interests: vanadium chemistry and biological inorganic chemistry; bioorganometallic chemistry; medicinal inorganic chemistry; metal-based drugs; drug discovery for neglected diseases
Special Issues, Collections and Topics in MDPI journals
Dr. Gonzalo Scalese

E-Mail Website
Guest Editor
1. Área Química Inorgánica, Facultad de Química, Universidad de la República, Montevideo, Uruguay
2. Laboratory Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, Uruguay
Interests: metal-based drugs; medicinal inorganic chemistry; biological inorganic chemistry, vanadium chemistry and biochemistry; drug discovery for neglected diseases; trypanosomes biochemistry; redox biology of trypanosomes

Special Issue Information

Dear Colleagues,

The remarkable chemical and biological properties of vanadium compounds have garnered significant attention in recent decades, spurring extensive research in their chemistry, biochemistry, and medicinal applications. Due to their potential as insulin-mimetic agents and anticancer therapeutics, along with their promising antibacterial and antiparasitic activities, vanadium coordination chemistry and biochemistry have become focal points of scientific inquiry. Researchers worldwide are actively investigating vanadium compounds to uncover their therapeutic potential, understand their health benefits, and elucidate their mechanisms of action.

Following the success of the first edition of this Special Issue, a second volume has been launched to showcase recent advances in vanadium chemistry, biochemistry, and medicinal chemistry. We anticipate that this issue will significantly influence the future trajectory of vanadium research. Therefore, we warmly invite you to contribute your latest findings to this collection.

Prof. Dr. Dinorah Gambino
Dr. Gonzalo Scalese
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Inorganics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vanadium compounds
  • vanadium chemistry
  • vanadium biological inorganic chemistry
  • vanadium-based drugs
  • vanadium biochemistry

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Related Special Issue

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

31 pages, 3410 KiB  
Article
Novel 8-Hydroxyquinoline-Derived V(IV)O, Ni(II), and Fe(III) Complexes: Synthesis, Characterization, and In Vitro Cytotoxicity Against Tumor Cells
by Joana Lopes, Leonor Côrte-Real, Íris Neto, Alice Alborghetti, Maël Dejoux, Nora V. May, Xavier Fontrodona, Isabel Romero, Alexandra M. M. Antunes, Catarina Pinto Reis, Maria Manuela Gaspar and Isabel Correia
Inorganics 2025, 13(5), 150; https://doi.org/10.3390/inorganics13050150 - 6 May 2025
Viewed by 330
Abstract
We report the synthesis and characterization of five novel metal complexes. Three of them are vanadium complexes with the general formula [VO(Ln)2], where Ln are Schiff bases derived from the condensation of 2-carbaldehyde-8-hydroxyquinoline with either 4-(2-aminoethyl)morpholine (L [...] Read more.
We report the synthesis and characterization of five novel metal complexes. Three of them are vanadium complexes with the general formula [VO(Ln)2], where Ln are Schiff bases derived from the condensation of 2-carbaldehyde-8-hydroxyquinoline with either 4-(2-aminoethyl)morpholine (L1), 3-morpholinopropylamine (L2) or 1-(2-aminoethyl)piperidine (L3). The two other metal complexes are [Ni(L1)2] and [Fe(L1)2]Cl. They were characterized by analytical, spectroscopic (Fourier transform infrared, UV-visible absorption), and mass spectrometric techniques as well as by single-crystal X-ray diffraction (for all [VO(Ln)2] complexes and [Ni(L1)2]). While, in the crystal structure, the V(IV)O complexes show distorted square–pyramidal geometry with the ligands bound as bidentate through quinolate NO donors, the Ni(II) complex shows octahedral geometry with two ligand molecules coordinated through NNO donors. Stability studies in aqueous media revealed that the vanadium complexes are not stable, undergoing oxidation to VO2(L), which was corroborated by 51V NMR and MS. This behavior is also observed in organic media, though at a significantly slower rate. The Ni complex exhibited small spectral changes over time in aqueous media. Nonetheless, all compounds show enhanced stability in the presence of bovine serum albumin (BSA). Fluorescence studies carried out for the Ni(II) and Fe(III) complexes indicate reversible binding to albumin. The cytotoxicity of the L1 metal complexes was assessed on melanoma (B16F10 and A375) and colon cancer (CT-26 and HCT-116) cell lines, with 5-fluorouracil (5-FU) as a reference drug. The V- and Ni complexes showed the lowest IC50 values (<10 μM) in either A375 or HCT-116 cells after 48 h of incubation, while the Fe(III) complex presented minimal antiproliferative effects. The complexes were generally more cytotoxic to human than murine cancer cells. Synergistic in vitro studies with 5-FU revealed antagonism in most cases, except in A375 cells, where an additive effect was observed for the combination with the V-complex. Overall, these compounds show promising potential for cancer treatment, mostly for melanoma. Full article
(This article belongs to the Special Issue New Trends in Vanadium Chemistry, Biochemistry, and Medicinal Chemistry, 2nd Edition)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop