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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Ribonucleotides in Genomic DNA: Molecular Mechanisms and Biological Implications

edited by

Francesca Storici

submission deadline 20 Oct 2025 | Viewed by 417 | Submission Open

Keywords: ribonucleotides in DNA; genomic RNA incorporation; ribonucleotide excision repair; ribonucleotide reductase; genome stability; function of ribonucleotides in DNA; DNA polymerase fidelity; ribonucleotide-induced mutations; ribonucleotide misincorporation; ribonucleotide in DNA structure

(This special issue belongs to the Section Molecular Biology)

Heavy Metal Toxicity and Female Infertility, Pregnancy Disorders, Fetal Growth and Development

edited by

Sakhila K. Banu

submission deadline 20 Oct 2025 | Viewed by 394 | Submission Open

Keywords: pregnancy disorders; preeclampsia; pre-term labor; endometriosis; infertility; uterine artery remodeling; ovarian failure; polycystic ovarian syndrome (PCOS) and premature ovarian failure (POF)]; fetal growth restriction; placental pathogenesis

(This special issue belongs to the Section Molecular Toxicology)

Nanocomposites and Their Biomedical Applications

edited by

Azeem Ullah

and Zhen Zhang

submission deadline 20 Oct 2025 | Viewed by 390 | Submission Open

Keywords: targeted drug delivery; tissue engineering; edible coatings; controlled release; wound healing; bioactive packaging; biosensing

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Pharmacology and Metabolic Signaling in Health and Disease

edited by

Prasanth Puthanveetil

submission deadline 20 Oct 2025 | Viewed by 390 | Submission Open

Keywords: molecular pharmacology; cellular signaling; signal transduction; mechanism of drugs; altered metabolism in disease states; systemic metabolism and health; altered synthesis and secretion of endogenous agents; lifestyle modifications; diet and exercise

(This special issue belongs to the Section Molecular Pharmacology)

Advancements in Protein Engineering and Structure Determination

edited by Ivan Campeotto and Shabir Najmudin

submission deadline 20 Oct 2025 | Viewed by 386 | Submission Open

Keywords: protein engineering; protein structure; protein design; protein modelling; protein stability

(This special issue belongs to the Section Molecular Biology)

Membrane Proteins and Ion Channels

edited by

Sheng-Nan Wu

submission deadline 20 Oct 2025 | Viewed by 369 | Submission Open

Keywords: membrane proteins; ion channels; cell membranes

(This special issue belongs to the Section Molecular Biophysics)

Translational Research in Angiogenesis—a Key Tool for Developing Therapeutic Strategies Towards Tissue Regeneration

edited by Ektoras Hadjipanayi

submission deadline 20 Oct 2025 | Viewed by 351 | Submission Open

Keywords: angiogenesis; wound bed; stromal microenvironment; stem cells; tissue repair; hypoxia; growth factors; molecular signaling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Functional Nanomaterials and Nanocomposites for Biomedical Application

edited by Gi Doo Cha

submission deadline 20 Oct 2025 | Viewed by 351 | Submission Open

Keywords: nanomaterials; nanocomposites; biomedicine; metal nanoparticles; drug delivery; bioelectronics

(This special issue belongs to the Section Molecular Nanoscience)

Recent Advancements in Studying Biomacromolecule–Ligand Interactions

edited by Guo-Ping Zhou

submission deadline 20 Oct 2025 | Viewed by 340 | Submission Open

Keywords: biomacromolecule– ligand interaction; X-ray crystallography; nuclear magnetic resonance (NMR) spectroscopy; surface plasmon resonance (SPR); isothermal titration calorimetry (ITC); fluorescence spectroscopy (FS); mass spectrometry (MS); drug discovery

(This special issue belongs to the Section Macromolecules)

The Medicinal Mechanism of Natural Products in Cancer Therapies

edited by

Clement G. Yedjou

submission deadline 20 Oct 2025 | Viewed by 339 | Submission Open

Keywords: natural product; phytochemicals; protein– ligand interaction; mechanism of action; drug discovery; prevention; treatment

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Heart Failure and Cardiac Remodeling: Molecular Mechanisms and Therapeutic Strategies

edited by

Antonio Lax

submission deadline 20 Oct 2025 | Viewed by 338 | Submission Open

Keywords: heart failure; cardiac remodeling; molecular mechanisms; therapeutic strategies; cardiomyopathy; biomarkers; gene therapy; regenerative medicine; pharmacology; inflammation; fibrosis; signal transduction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Applications of Deep Learning in Kidney Diseases

edited by

Michele Provenzano

Vincenzo Pezzi

and

Gianluigi Zaza

submission deadline 20 Oct 2025 | Viewed by 320 | Submission Open

Keywords: kidney biomarkers; kidney diseases; predictive biomarkers; deep learning; personalized therapy; digital health

(This special issue belongs to the Section Molecular Informatics)

Prostate Diseases: Focus on Hormone Therapies and Targeted Interventions

edited by Gabriel Campolina-Silva and Héctor Contreras

submission deadline 20 Oct 2025 | Viewed by 316 | Submission Open

Keywords: urinary disease; prostate cancer; hormone; therapeutic strategy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research Progress of Antibacterial Material

edited by

Victor M. Castano

submission deadline 20 Oct 2025 | Viewed by 313 | Submission Open

Keywords: antibacterial; microcides; nanoparticles; nanostructures; molecular engineering; ROS induction

(This special issue belongs to the Section Materials Science)

Advances in Molecular Research of Nuclear Receptors in Disease

edited by Shigeaki Kato

submission deadline 20 Oct 2025 | Viewed by 308 | Submission Open

Keywords: nuclear receptors; steroid hormones; fat-soluble vitamins; cancer; non-communicable diseases; synthetic ligands

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms Underlying Pancreatic Cancer Progression and Drug Resistance

edited by Daoyan Wei and Robert S. Bresalier

submission deadline 20 Oct 2025 | Viewed by 297 | Submission Open

Keywords: pancreatic cancer; cancer progression; therapeutic resistance; targeted therapies; oncogenic pathways; molecular pathogenesis; tumor heterogeneity; tumor microenvironment; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Antituberculous Drugs: Progress and Challenges

edited by Ana Maria Telmo Dias Pereira Vicente Cabral and

Ana Cristina Faria Ribeiro

submission deadline 20 Oct 2025 | Viewed by 296 | Submission Open

Keywords: antituberculostatic drugs; carriers; bioavailability; delivery systems

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Insights into Addiction

edited by

Aleksandra Suchanecka

and

Jolanta Chmielowiec

submission deadline 20 Oct 2025 | Viewed by 293 | Submission Open

Keywords: addiction; dependence; neurobiology; reward; neuroplasticity; biostatistics

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Sepsis: Pathogenesis, Biomarkers, Treatments and Prognosis

edited by Francesca Innocenti

submission deadline 20 Oct 2025 | Viewed by 289 | Submission Open

Keywords: sepsis phenotypes; hemodynamic stabilization; fluids; vasopressors; diagnostic biomarkers; tailored approach; immune modulation; immunomodulatory therapy; prognostic stratification

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Molecular and Physiological Responses of Insects to Biotic, Abiotic and Xenobiotic Constraints

edited by

Farman Ullah

Shuo Yan

and Yaobin Lu

submission deadline 20 Oct 2025 | Viewed by 287 | Submission Open

Keywords: climatic changes; chemical insecticides; insect adaptation mechanisms; resistance mechanisms; ecosystem services; insect ecology; thermal stress adaptations

(This special issue belongs to the Section Molecular Biology)

Germline Mutations, Somatic Mutations and Their Phenotypic Effects in Humans and Animals

edited by

Teruaki Tozaki

submission deadline 20 Oct 2025 | Viewed by 286 | Submission Open

Keywords: germline mutations; somatic mutations; genetic disorders; single nucleotide variant (SNV); insertion; deletion; copy number variation (CNV); structure variation (SV); sports enhancement; cancer; melanoma; coat color

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular and Cellular Mechanisms in Mood Disorders

edited by Sara Palumbo

submission deadline 20 Oct 2025 | Viewed by 279 | Submission Open

Keywords: neurobiology of mood disorders; intracellular signalling in mood disorders; neurophysiological alterations in mood disorders; genetic risk of mood disorders; pharmacological targets for mood disorders

(This special issue belongs to the Section Molecular Neurobiology)

Modulation of Protein Structure and Function by Lipids: 2nd Edition

edited by

Avia Rosenhouse-Dantsker

submission deadline 20 Oct 2025 | Viewed by 275 | Submission Open

Keywords: protein modulation by lipids; phosphoinositides; cholesterol; sterols; fatty acids; G protein-coupled receptors; ion channels; transporters

(This special issue belongs to the Section Biochemistry)

Nose-to-Brain Drug Delivery: Opportunities and Challenges

edited by

Daisuke Inoue

submission deadline 20 Oct 2025 | Viewed by 273 | Submission Open

Keywords: nose-to-brain drug delivery; brain drug delivery system; CNS diseases; intranasal administration; nasal formulation

(This special issue belongs to the Section Molecular Pharmacology)

Molecular and Cellular Aspects of Autoimmune and Inflammatory Rheumatic Diseases: Second Edition

edited by Marzena Helena Olesińska and Magdalena Szmyrka

submission deadline 20 Oct 2025 | Viewed by 273 | Submission Open

Keywords: autoimmune rheumatic diseases; inflammatory rheumatic diseases; arthritis; connective tissue diseases

(This special issue belongs to the Section Molecular Immunology)

Advances in the 3D Culture Systems and Organoids for Disease Modeling and Therapeutics

edited by Su-Yun Lyu

submission deadline 20 Oct 2025 | Viewed by 265 | Submission Open

Keywords: 3D culture systems; organoids; disease modeling; drug discovery; regenerative; medicine biomaterials; molecular mechanisms; cancer; immunology; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Sjögren's Syndrome, 4th Edition

edited by

Biji Theyilamannil Kurien

submission deadline 20 Oct 2025 | Viewed by 256 | Submission Open

Keywords: autoimmunity; sjö gren’ s syndrome; autoantibodies; salivary gland; lacrimal gland; dry eyes/mouth

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research in Novel Immune Adjuvants

edited by Bei Li

submission deadline 20 Oct 2025 | Viewed by 251 | Submission Open

Keywords: adjuvants; vaccine; immunology; toxicology; biology

(This special issue belongs to the Section Molecular Immunology)

Synthesis Manufacturing and Biomedical Applications of Nanofibers Scaffold

edited by

Marco Antonio Álvarez Pérez

and

Vincenzo Guarino

submission deadline 20 Oct 2025 | Viewed by 244 | Submission Open

Keywords: scaffold manufacturing; nanofibers; 3D platforms; biohybrid scaffolds; biomolecules; functionalization; biomaterials

(This special issue belongs to the Section Molecular Nanoscience)

Hormone Replacement Therapy

edited by

Marco Antonio Botelho

and

Raouf A. Khalil

submission deadline 20 Oct 2025 | Viewed by 241 | Submission Open

Keywords: hormone replacement therapy; molecular insights; endocrine signaling; precision medicine; gene expression; epigenetics; non-coding RNAs; personalized regimens

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Mechanism of Diabetes and Its Complications

edited by Michishige Terasaki

submission deadline 20 Oct 2025 | Viewed by 239 | Submission Open

Keywords: diabetes; hyperglycemia; oxidative stress; atherosclerosis; comorbidity; complication; metabolic metabolic dysfunction associated steatotic liver disease (MASLD); steatohepatitis (MASH); chronic kidney disease (CKD); heart failure; heart failure with preserved ejection fraction (HFpEF); coronary artery disease (CAD)

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Wheat-Related Intestinal Diseases: From Molecular Basis to Potential Therapy

edited by Alessandra Camarca and Vera Rotondi-Aufiero

submission deadline 20 Oct 2025 | Viewed by 232 | Submission Open

Keywords: CeD pathogenesis; NCWS molecular basis; therapies alternative to GFD; gluten digestion strategies; gluten detoxification strategies; experimental models; new tools and/or biomarkers for diagnosis and follow-up

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Molecules from Food Waste in Food Packaging Applications

edited by

Jennifer Gubitosa

submission deadline 20 Oct 2025 | Viewed by 230 | Submission Open

Keywords: wastes upcycling; waste management; circular economy; green chemistry; bioactive molecules; agri-food wastes and by-products; food packaging; active packaging

(This special issue belongs to the Section Materials Science)

Chemokine and Chemokine Receptor in Human Physiological and Pathological Processes

edited by

Cinzia Giagulli

submission deadline 20 Oct 2025 | Viewed by 227 | Submission Open

Keywords: chemokines; chemokine receptors; cancer; inflammatory disease; pathogens; immune system; homeostasis

(This special issue belongs to the Section Molecular Immunology)

Phenotypes to Genotypes: Breaking the Chains of EGFR Addiction in Lung Cancer

edited by

Massimiliano Mancini

submission deadline 20 Oct 2025 | Viewed by 224 | Submission Open

Keywords: EGFR-mutant lung cancer; EGFR; NSCLC; tumor heterogeneity; resistance mechanisms

(This special issue belongs to the Section Molecular Oncology)

Innovative Delivery Technologies for Nucleic Acid Therapeutics: From In Vitro to In Vivo Applications

edited by Karim Daliri

submission deadline 20 Oct 2025 | Viewed by 219 | Submission Open

Keywords: nucleic acid therapeutics; nucleic acid delivery; mRNA; siRNA; ASOs; plasmid DNA; CRISPR/Cas9

(This special issue belongs to the Section Molecular Biology)

The Activity and Underlying Mechanisms of Anticancer Drugs

edited by Vilma Petrikaitė

submission deadline 20 Oct 2025 | Viewed by 218 | Submission Open

Keywords: anticancer drugs; molecular mechanisms of drug action; drug resistance; novel targeted therapies

(This special issue belongs to the Section Molecular Pharmacology)

Functional Polymeric Materials: From Synthesis to Applications: 2nd Edition

edited by

Marta Fernández-García

and

Alexandra Muñoz-Bonilla

submission deadline 20 Oct 2025 | Viewed by 218 | Submission Open

Keywords: natural polymers; bio-based polymers; block copolymers; micelles; polymer chemistry; (hydro)gels; (bio)applications; degradability

(This special issue belongs to the Section Materials Science)

p53 in Cell Death and Cellular Senescence

edited by

Ji Hoon Jung

submission deadline 20 Oct 2025 | Viewed by 214 | Submission Open

Keywords: p53; apoptosis; ferroptosis; senescence; cancer cell

(This special issue belongs to the Section Biochemistry)

Advances in Kidney Transplantation

edited by Zeljko Kikic

submission deadline 20 Oct 2025 | Viewed by 214 | Submission Open

Keywords: chronic rejection; antibody-mediated rejection; immunosuppression; BK virus nephropathy (BKVAN); diagnostic challenges

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Chronic Obstructive Pulmonary Diseases

edited by

Evangelia Fouka

submission deadline 20 Oct 2025 | Viewed by 211 | Submission Open

Keywords: COPD; epigenetics; mitochondrial dysfunction; autophagy; proteomics; single-cell sequencing; metabolomics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neuronal Differentiation: From Pathology to Therapeutic Strategies

edited by

Marzia Lecchi

submission deadline 20 Oct 2025 | Viewed by 210 | Submission Open

Keywords: neuronal differentiation; molecular mechanisms of neurodifferentiation; neurodegenerative diseases; ischemic stroke; spinal cord and brain injury; neural tissue recovery; regeneration therapy; stem cells

(This special issue belongs to the Section Molecular Neurobiology)

COVID-19: Molecular Research and Novel Therapy

edited by

Mihaela Chivu-Economescu

submission deadline 20 Oct 2025 | Viewed by 206 | Submission Open

Keywords: SARS-CoV-2; virus-host interaction; immune response; antiviral agents; vaccines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microbiome Connections in Age-Related Diseases

edited by Shalini Jain

submission deadline 20 Oct 2025 | Viewed by 201 | Submission Open

Keywords: microbiome; aging; age-related diseases; Alzheimer’ s; dementia

(This special issue belongs to the Section Molecular Microbiology)

RNA Modifications in Response to Physical Activity: Implications for Rehabilitation and Disease Management

edited by Roberto Tedeschi and Francesca Gorini

submission deadline 20 Oct 2025 | Viewed by 201 | Submission Open

Keywords: RNA modifications; non-coding RNAs (ncRNAs); physical activity; gene expression; rehabilitation and disease management; epigenetic regulation; exercise-induced RNA expression; miRNA in inflammation control

(This special issue belongs to the Section Molecular Biology)

Telomeres in Development, Senescence and Genome Instability: 2nd Edition

edited by Michal Zalzman

submission deadline 20 Oct 2025 | Viewed by 198 | Submission Open

Keywords: telomere disorders and cell death; telomere factors as therapeutic targets in cancer; telomeres and genome stability; telomeres in aging and senescence

(This special issue belongs to the Section Molecular Genetics and Genomics)

Crosstalk Between Bioactive Compounds and Disease

edited by

Mónica Carrera

submission deadline 20 Oct 2025 | Viewed by 195 | Submission Open

Keywords: bioactive compounds; human health; omics technologies; nanotechnology; drug development

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Pathways of Proteostasis in Aging and Diseases

edited by Emmanouil Kyriakakis

submission deadline 20 Oct 2025 | Viewed by 194 | Submission Open

Keywords: proteostasis; aging; neurodegenerative diseases; UPR; autophagy; ER stress; HSR; longevity; healthspan; quality control mechanisms; muscle atrophy; cardiovascular disease

(This special issue belongs to the Section Molecular Biology)

Protein-Based Composite Materials: 2nd Edition

edited by

Xiao Hu

submission deadline 20 Oct 2025 | Viewed by 189 | Submission Open

Keywords: protein biopolymer; composite film; fiber; foam; gel; particle; sensor; and device; biomacromolecules and functional materials; polymer composite design and characterization; protein physical and chemical properties

(This special issue belongs to the Section Materials Science)

Pain Chronicity and Relief: From Molecular Basis to Rehabilitation

edited by

Katsuya Kami

submission deadline 20 Oct 2025 | Viewed by 187 | Submission Open

Keywords: exercise-induced hypoalgesia; barrier factor; chronic pain; neuropathic pain; spinal cord dorsal horn; mesocorticolimbic system; myokine; descending pain modulatory system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 2851-2900 on page 58 of 70.

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