Translational Research in Angiogenesis—a Key Tool for Developing Therapeutic Strategies Towards Tissue Regeneration
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 October 2025 | Viewed by 351
Special Issue Editor
Interests: angiogenesis; wound healing; hypoxia; growth factors; autologous therapy
Special Issue Information
Dear Colleagues,
I am delighted to announce a new Special Issue of the International Journal of Molecular Sciences, entitled “Translational Research in Angiogenesis—a Key Tool for Developing Therapeutic Strategies Towards Tissue Regeneration”.
Physiological tissue regeneration requires an optimal angiogenic response, which dictates cellular function within the wound bed. The induction of new blood vessel formation is a key pre-requisite for tissue repair, since it permits cell migration, proliferation and differentiation. While our understanding of the various biological processes that support wound angiogenesis has significantly improved in the past decades, there are still significant gaps in our knowledge of the detailed mechanisms that mediate the effects of tissue oxygen tension / hypoxia regulation and pro-/anti-angiogenic growth factor production on cellular function. As a result, there is currently a scarcity of effective therapeutic approaches towards the healing of chronic wounds, as well as the treatment of tissue damage occurring as a result of microvascular pathology.
The scope of this issue will include research on the pathophysiological mechanisms (biochemical, molecular, cellular and physical processes) through which regulation of cellular responses mediates angiogenesis-driven tissue regeneration and wound repair. We are particularly interested in papers that will increase our knowledge and understanding of angiogenic ‘switches’ within the wound healing cascade, that can be turned on on-demand, and can as such inform the design of clinically applicable therapeutic approaches, including cellular and molecular therapies. Original reports, case reports and reviews will be considered.
Dr. Ektoras Hadjipanayi
Guest Editor
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Keywords
- angiogenesis
- wound bed
- stromal microenvironment
- stem cells
- tissue repair
- hypoxia
- growth factors
- molecular signaling
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