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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Research on the Antioxidant, Anti-Inflammatory, and Antibacterial Activities of Natural Products

edited by

Carmen Lizette Del Toro Sánchez

submission deadline 31 Jul 2026 | Viewed by 21 | Submission Open

Keywords: natural bioactive compounds; antioxidant mechanisms; anti-inflammatory pathways; antibacterial activity; agro-industrial byproducts; molecular docking; structure– activity relationship (SAR); omics technologies; drug delivery systems; nanobiotechnology; bioavailability

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Current Issues in DNA Damage and DNA Repair

edited by Silvina B. Nadin

submission deadline 31 Jul 2026 | Viewed by 15 | Submission Open

Keywords: genome instability; DNA damage response; DNA repair mechanisms; cancer; therapeutic targets; preclinical studies; translational studies; DNA repair and immune system; PARP inhibitors; BRCA1/2

(This special issue belongs to the Section Molecular Biology)

Genetic and Molecular Strategies to Soybean Improvement

edited by

Junming Sun

submission deadline 31 Jul 2026 | Viewed by 8 | Submission Open

Keywords: soybean; genome editing; CRISPR/Cas9; quantitative trait loci (QTL); marker-assisted selection; functional genomics; molecular breeding; crop improvement; gene expression; genetics and breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Development of Responsive Nanoparticles for Cancer Therapy, 3rd Edition

edited by

Jordi Puiggalí

submission deadline 31 Jul 2026 | Viewed by 4 | Submission Open

Keywords: nanoparticles; liposomes; polymersomes; micelles; surface functionalization; cell targeting; stimuli-sensitivity; drug delivery; therapeutic applications; diagnostic applications; cancer treatment

(This special issue belongs to the Section Molecular Nanoscience)

Mechanisms and Innovations in Natural Killer Cell-Based Immunotherapy

edited by

Dipnarine Maharaj

submission deadline 31 Jul 2026 | Viewed by 3 | Submission Open

Keywords: natural killer cells; immunotherapy; CAR-NK; cancer therapy; adoptive cell transfer; immune modulation; tumor microenvironment; cell engineering; hematologic malignancies; viral infections

(This special issue belongs to the Section Molecular Immunology)

From Natural Products to Synthetic Small-Molecule Antioxidants: Mechanistic and Kinetic Foundations for Drug Discovery

edited by Cvijeta Jakobušić Brala

submission deadline 31 Jul 2026 | Viewed by 3 | Submission Open

Keywords: oxidative stress; antioxidant mechanisms; reaction kinetics; natural products; small-molecule antioxidants; drug discovery

(This special issue belongs to the Section Molecular Pharmacology)

Recent Advances in Plant–Microbe Interactions

edited by

Daowan Lai

submission deadline 31 Jul 2026 | Viewed by 1 | Submission Open

Keywords: plant– microbe interactions; plant defense; pathogenicity; genetics; biochemistry; artificial intelligence; synthetic biology; symbiosis; plant protection

(This special issue belongs to the Section Molecular Plant Sciences)

Latest Advances in Gut–Brain Axis Research

edited by Qi Su

submission deadline 31 Jul 2026 | Viewed by 1 | Submission Open

Keywords: gut-brain axis; microbial metabolites; neuroinflammation; intestinal permeability; neurotransmitter; short-chain fatty acids (SCFAs); vagus nerve signaling; metabolomics

(This special issue belongs to the Section Molecular Neurobiology)

SGLT2 Inhibitors and GLP/GIP/Glucagon Agonists: From Fundamental Mechanisms to Clinical Translation

edited by

Cosmin Mihai Vesa

submission deadline 31 Jul 2026 | Viewed by 1 | Submission Open

Keywords: SGLT2 inhibitors; GLP-1 receptor agonists; GIP; glucagon; multi-agonists; cardiometabolic disease; renal protection; obesity; translational research

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecularly Engineered Nanomaterials for Energy Conversion, Storage, and AI-Driven Materials Discovery

edited by

Atanu Jana

submission deadline 31 Jul 2026 | Submission Open

Keywords: molecular engineering; energy conversion and storage; hydrogen evolution reaction (HER); oxygen evolution reaction (OER); batteries and supercapacitors; optical properties; light-emitting diodes; AI-assisted materials design

(This special issue belongs to the Section Molecular Nanoscience)

Nutrition for Muscle Health and Metabolism

edited by

Hira Shakoor

submission deadline 31 Jul 2026 | Submission Open

Keywords: nutrition; skeletal muscle; muscle metabolism; mitochondrial function; insulin sensitivity; myokines; metabolic health; metabolic disease

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Fluorescent Nanoparticles: Composition, Properties, and Biomedical Applications

edited by Bonghwan Chon

submission deadline 1 Aug 2026 | Viewed by 106 | Submission Open

Keywords: fluorescent nanoparticles; bioimaging; targeted drug delivery; cancer nanotherapy; quantum dots; surface functionalization; biomedical nanotechnology; theragnostic; fluorescence imaging; deep tissue imaging

(This special issue belongs to the Section Molecular Nanoscience)

New Advances in Animal Reproduction

edited by Valdevane Rocha Araújo

submission deadline 10 Aug 2026 | Viewed by 87 | Submission Open

Keywords: folliculogenesis; oogenesis; oocyte maturation; follicle growth; preantral follicles; antral follicles; spermatogenesis; spermatozoa; bioengineering; scaffolds

(This special issue belongs to the Section Molecular Biology)

Molecular Pathogenesis and Treatments of Pediatric Leukemias

edited by

Joanna Zawitkowska

submission deadline 10 Aug 2026 | Viewed by 47 | Submission Open

Keywords: monoclonal antibodies; tyrosine kinase inhibitors; CAR-T; chemotherapy; drug induced toxicity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Development and Hormonal Signaling

edited by

Naoufal Lakhssassi

submission deadline 20 Aug 2026 | 6 articles | Viewed by 14242 | Submission Open

Keywords: plant growth; reproductive growth; phytohormones; signal transduction; transcription factors; root development; shoot development; floral development; seed development; environmental interactions; regulatory networks; apical dominance

(This special issue belongs to the Section Molecular Plant Sciences)

Toxicity Mechanism of Emerging Pollutants: 2nd Edition

edited by

Monika Naumowicz

and

Joanna Kotyńska

submission deadline 20 Aug 2026 | 4 articles | Viewed by 5358 | Submission Open

Keywords: emerging pollutant; toxicology; cancer; EDC; pesticides; microplastic; human cell lines; environment; molecular mechanisms

(This special issue belongs to the Section Molecular Toxicology)

Molecular Research on Depression—2nd Edition

edited by

Magdalena Sowa-Kućma

submission deadline 20 Aug 2026 | 2 articles | Viewed by 5267 | Submission Open

Keywords: depression; epigenetics; animal models of depression; serotonin; glutamate; dopamine; neurotrophic factors

(This special issue belongs to the Section Molecular Neurobiology)

Extracellular Vesicles (EVs) in Cancer Progression and Metastasis: Molecular Insights and Clinical Outlook

edited by Alfredo Cappariello

submission deadline 20 Aug 2026 | 2 articles | Viewed by 5184 | Submission Open

Keywords: mammalian extracellular vesicles; plant-derived extracellular vesicles; bacterial-derived extracellular vesicles; cancer progression; cell migration and invasion; tumor microenvironment; epithelial-to-mesenchymal transition (EMT); drug delivery; diagnostics; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Functional Genomics in Translational Medicine

edited by

Cornelia Braicu

, Oana Zanoaga and

Ștefan Strilciuc

submission deadline 20 Aug 2026 | 2 articles | Viewed by 4942 | Submission Open

Keywords: functional genomics; omics approaches; drug response/resistance; therapeutic targets; genomics and transcriptomic alteration; bioinformatic analysis; data integration; human disease; personalized medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Seed Development and Germination

edited by

Sławomir Borek

Łukasz Wojtyla

and

Małgorzata Garnczarska

submission deadline 20 Aug 2026 | 3 articles | Viewed by 4906 | Submission Open

Keywords: seed aging; seed development; seed dormancy; seed germination; seed metabolism; seed preservation; seed priming; seed responses to stress

(This special issue belongs to the Section Molecular Plant Sciences)

Fish Nutrition, Biochemical Pathways, and Physiological Adaptations

edited by Paula Simó-Mirabet and Fernando Naya-Català

submission deadline 20 Aug 2026 | 2 articles | Viewed by 4095 | Submission Open

Keywords: fish; nutrition; metabolism; physiology; growth performance; fish stress; transcriptomics; metataxonomics; metagenomics; epigenomics; aquaculture

(This special issue belongs to the Section Molecular Biology)

MicroRNAs and mRNA in Human Health and Disease

edited by

Paulina Gil-Kulik

submission deadline 20 Aug 2026 | 5 articles | Viewed by 3899 | Submission Open

Keywords: stem cells; mesenchymal stem cells; gene expression; microRNA; mRNA

(This special issue belongs to the Section Molecular Biology)

Plant Responses to Heavy Metals: From Deficiency to Excess, 2nd Edition

edited by

Anna D. Kozhevnikova

and

Ilya Vladimirovich Seregin

submission deadline 20 Aug 2026 | 2 articles | Viewed by 2168 | Submission Open

Keywords: heavy metals; deficiency; metal toxicity; metal (hyper-)accumulation; mechanisms of metal tolerance; metal transport; metal uptake; metal sequestration; metal homeostasis

(This special issue belongs to the Section Molecular Plant Sciences)

Ferroptosis and Cuproptosis: Mechanism and Crosstalk in Cancer, Neurodegeneration, and Metabolic Syndrome

edited by

Rosanna Squitti

submission deadline 20 Aug 2026 | 2 articles | Viewed by 1788 | Submission Open

Keywords: ferroptosis; cuproptosis; Alzheimer's disease; colorectal cancer; neurodegeneration; metabolic syndrome; regulated cell death; iron metabolism; copper metabolism; psychiatric disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antibiotics Science: Molecular Insights, Detection Strategies, Resistance Challenges and Interdisciplinary Applications

edited by

Lidia Magerusan

submission deadline 20 Aug 2026 | 2 articles | Viewed by 1545 | Submission Open

Keywords: antibiotics; antibiotic molecular design and synthesis; antibiotic action mechanism; antibiotics resistance; environmental contamination; therapeutic monitoring; antibiotic sensing and detection; food and environmental safety

(This special issue belongs to the Section Molecular Microbiology)

Advances in the Synthesis and Study of Novel Bioactive Molecules

edited by

Adriana Georgieva Bakalova

and

Emiliya Demireva Cherneva

submission deadline 20 Aug 2026 | 1 articles | Viewed by 948 | Submission Open

Keywords: organic compounds; metal complexes; bioactive molecules

(This special issue belongs to the Section Biochemistry)

Molecular Research on Embryo Developmental Potential: 2nd Edition

edited by

Jan Tesarik

submission deadline 20 Aug 2026 | 1 articles | Viewed by 750 | Submission Open

Keywords: embryo developmental potential; oocyte quality; sperm quality; non-invasive techniques; molecular biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Decoding the Microbial Influence on Host Gene Expression

edited by

Damian Kołat

and

Mateusz Kciuk

submission deadline 20 Aug 2026 | 1 articles | Viewed by 602 | Submission Open

Keywords: microbiota; host; gene expression; in silico; bioinformatics; in vitro; in vivo

(This special issue belongs to the Section Molecular Microbiology)

Structure, Properties, and Applications of Carbon Materials

edited by

Javier Arcibar-Orozco

submission deadline 20 Aug 2026 | 1 articles | Viewed by 509 | Submission Open

Keywords: carbon-based structures; diamonds; carbon quantum dots; carbon composites; graphene; nanotubes

(This special issue belongs to the Section Materials Science)

Peripheral Neuropathy: Exploring Pathogenic Pathways and Therapeutic Approaches

edited by Yuehling Hsieh

submission deadline 20 Aug 2026 | Viewed by 244 | Submission Open

Keywords: peripheral neuropathy; biochemical mechanisms; biomarkers; nerve regeneration; therapeutic approaches; pain management; denervated muscle atrophy; translational medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Aspects of Diabetes and Its Complications

edited by

Giuseppe Murdolo

submission deadline 20 Aug 2026 | Viewed by 217 | Submission Open

Keywords: obesity; insulin resistance; type 2 diabetes; atherosclerosis; endothelial dysfunction; cardiovascular disease; peripheral artery disease; diabetic feet; diabetic micoangiopathy; diabetic neuropathy; regenerative medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Cellular Basis of Oral Immunology

edited by

Kenichi Kumagai

submission deadline 20 Aug 2026 | Viewed by 182 | Submission Open

Keywords: oral immunology; oral mucosa; immune tolerance; oral microbiome; oral diseases; periodontium; innate immunity; adaptive immunity

(This special issue belongs to the Section Molecular Immunology)

Lipopolysaccharide as a Drug Target

edited by

Martina Schmidt

submission deadline 20 Aug 2026 | Viewed by 157 | Submission Open

Keywords: tissue barriers; neuroinflammation; macrophages; microglia; organoids; scaffolds; infections; cry-EM

(This special issue belongs to the Section Molecular Pharmacology)

New Molecular Insights into Antimicrobial Peptides

edited by

Gloria Bua

submission deadline 20 Aug 2026 | Viewed by 114 | Submission Open

Keywords: antimicrobial peptides; mode of action; molecular mechanism of biological activity; molecular targets; molecular modeling; structure– activity relationship

(This special issue belongs to the Section Molecular Microbiology)

Vitamin D in Reproductive Disorders: Determinants, Metabolism, and Downstream Biological Mechanisms

edited by

Eugenia Mata-Greenwood

submission deadline 20 Aug 2026 | Viewed by 99 | Submission Open

Keywords: vitamin D; perinatal corticosteroids; placental insufficiency; intrauterine growth restriction; cortisol metabolism

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Effects of Radiation in Health and Disease

edited by

Raffaella Lazzarini

submission deadline 20 Aug 2026 | Viewed by 39 | Submission Open

Keywords: extremely low-frequency magnetic fields; proteins and gene interaction; ionizing and non-ionizing radiations

(This special issue belongs to the Section Molecular Biology)

Natural Compounds in Cancer Treatment and Prevention: Mechanisms, Evidence, and Clinical Perspectives

edited by Vitor Engracia Valenti

submission deadline 25 Aug 2026 | Viewed by 67 | Submission Open

Keywords: natural compounds; cancer treatment; cancer prevention; bioactive phytochemicals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Current Research on Lipidomics

edited by Agata Kot-Wasik

submission deadline 25 Aug 2026 | Viewed by 40 | Submission Open

Keywords: lipids ; hyphenated chromatography– mass spectrometry ; biological samples ; sample preparation

(This special issue belongs to the Section Molecular Biology)

Neurotransmitter Dysregulation in Brain Disease: Focus on Epilepsy and Its Comorbidities

edited by

Giuseppe Di Giovanni

submission deadline 30 Aug 2026 | Viewed by 126 | Submission Open

Keywords: neurotransmitter dysregulation; epilepsy; addiction; serotonin; GABA; molecular neuroscience; neuropharmacology; brain networks

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms Fueling Glioblastoma Progression and Resistance: Emerging Therapeutic Opportunities

edited by

Anthony Lemarié

submission deadline 30 Aug 2026 | Viewed by 81 | Submission Open

Keywords: glioblastoma; cancer stem cells; radioresistance; chemoresistance; targeted therapies; tumor plasticity; tumor heterogeneity; invasion; immune escape

(This special issue belongs to the Section Molecular Neurobiology)

MiRNA Regulation in the Early PME/TME: The Role of Non-Cancer Cells and the ECM in Solid Tumours

edited by

Kurt Sartorius

submission deadline 30 Aug 2026 | Viewed by 63 | Submission Open

Keywords: microRNAs; early tumor microenvironment (TME); stromal/ECM interaction; vascularization; ECM remodelling; signalling pathways

(This special issue belongs to the Section Molecular Oncology)

Evolutionary Genetics of Pathogens

edited by Leonardo Gabriel Panunzi

submission deadline 30 Aug 2026 | Viewed by 43 | Submission Open

Keywords: pathogenicity; genome evolution; horizontal gene transfer; virulence factors; comparative genomics; pangenome analysis mobile genetic elements; computational biology; machine learning; host– pathogen interactions

(This special issue belongs to the Section Molecular Genetics and Genomics)

Latest Advances in Antiparasitic Agents

edited by Olga S. Koutsoni and

Maria Agallou

submission deadline 30 Aug 2026 | Viewed by 33 | Submission Open

Keywords: parasite genomics; parasite proteomics; metabolic pathways; parasite– host interactions; drug targets; mechanisms of drug resistance

(This special issue belongs to the Section Molecular Pharmacology)

Cardioprotective Mechanisms in Myocardial Ischemia

edited by Virginia Pérez and Verónica D’annunzio

submission deadline 30 Aug 2026 | Viewed by 31 | Submission Open

Keywords: myocardial ischemia; ischemia– reperfusion injury; cardioprotection; molecular signaling; oxidative stress; inflammation; cardiac remodeling; therapeutic targets; translational cardiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomarkers and Early Detection Strategies of Ovarian Tumors: 2nd Edition

edited by Lukasz Szafron

submission deadline 30 Aug 2026 | Viewed by 19 | Submission Open

Keywords: biomarker; ovarian cancer; borderline ovarian tumor; genetic variant; epigenetics; transciptomics; proteomics; metabolomics; ovarian tumor prevention; ovarian tumor treatment

(This special issue belongs to the Section Molecular Oncology)

The Role of Neuropeptides and Their GPCRs in the Neuroendocrine System

edited by

Hirotaka Sakamoto

submission deadline 31 Aug 2026 | Viewed by 572 | Submission Open

Keywords: neuropeptides; G-protein-coupled receptors (GPCRs); neuroendocrine system; signal transduction; hypothalamus

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Neuropathology of Alzheimer’s Disease: Tau, Amyloid-β, and Novel Protein Associations

edited by

José Luna-Muñoz

and Alejandra Morlett-Paredes

submission deadline 31 Aug 2026 | Viewed by 105 | Submission Open

Keywords: tauopathies and protein aggregation; amyloid beta and neurotoxicity; emerging proteins in neurodegeneration; molecular and morphological biomarkers; innovative therapies and experimental targets; artificial intelligence and neuropathological analysis

(This special issue belongs to the Section Molecular Neurobiology)

Lipid Metabolism in Aging and Diseases: From Mechanisms to Therapy

edited by

Dominique Delmas

submission deadline 31 Aug 2026 | Viewed by 47 | Submission Open

Keywords: lipid metabolism; degenerative diseases; cardiovascular pathologies; neurodegeneration; inflammation; autoimmunity; cancer; lipid droplets; bioactive molecules; drug repositioning; oxidative stress; mitochondrial dysfunction; inflammatory processes

(This special issue belongs to the Section Biochemistry)

Animal Models for Neurobiological Diseases

edited by

Hiroki Toyoda

and

Jana Tchekalarova

submission deadline 31 Aug 2026 | Viewed by 43 | Submission Open

Keywords: animal models; mice; zebrafish; Alzheimer's disease; Parkinson's disease; multiple sclerosis; neuropsychiatric conditions

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Alzheimer's Disease and Related Dementias: From Pathogenesis to Therapeutics

edited by

Amal Kaddoumi

submission deadline 31 Aug 2026 | Viewed by 41 | Submission Open

Keywords: Alzheimer's disease; cerebral amyloid angiopathy; blood– brain barrier; cerebrovascular dysfunction; neuroinflammation; therapeutic development; translational research

(This special issue belongs to the Section Molecular Neurobiology)

Displaying special issue 3101-3150 on page 63 of 64.

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