Submit to IJMS Review for IJMS Propose a Special Issue

Journal Menu

Journal Browser

Special Issues

International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

Section

Search by Title/Keyword

Order results

Display

Results per page

Recent Advances of Novel Pharmaceutical Designs for Anticancer Therapies, 4th Edition

edited by

Bernhard Biersack

submission deadline 25 Aug 2026 | 3 articles | Viewed by 3266 | Submission Open

Keywords: cancer; anticancer drugs; drug design; targeted therapy; immunotherapy; molecular target; molecular mechanism; drug resistance

(This special issue belongs to the Section Molecular Pharmacology)

Natural Compounds in Cancer Treatment and Prevention: Mechanisms, Evidence, and Clinical Perspectives

edited by

Vitor Engracia Valenti

submission deadline 25 Aug 2026 | 2 articles | Viewed by 3009 | Submission Open

Keywords: natural compounds; cancer treatment; cancer prevention; bioactive phytochemicals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Current Research on Lipidomics

edited by

Agata Kot-Wasik

submission deadline 25 Aug 2026 | 1 articles | Viewed by 2479 | Submission Open

Keywords: lipids ; hyphenated chromatography–mass spectrometry ; biological samples ; sample preparation

(This special issue belongs to the Section Molecular Biology)

Muscle Atrophy Molecular Signaling Regulation

edited by

Tatiana Kostrominova

submission deadline 25 Aug 2026 | 1 articles | Viewed by 963 | Submission Open

Keywords: skeletal muscle atrophy; loss of mass and contractile force; molecular signaling pathways

(This special issue belongs to the Section Molecular Biology)

Circadian Clocks and Immunity: Unraveling the Rhythm of Immune Function

edited by Vincent Yuan and

Telma Quintela

submission deadline 25 Aug 2026 | Viewed by 378 | Submission Open

Keywords: circadian rhythm; biological clocks; immune regulation; innate immunity; adaptive immunity; inflammation; chronotherapy; immune-metabolic regulation; tissue-resident immune cells; autoimmune disease

(This special issue belongs to the Section Molecular Immunology)

The Cellular and Molecular Mechanisms of Sensory Map Development

edited by

Anindya Ganguly

submission deadline 25 Aug 2026 | Viewed by 265 | Submission Open

Keywords: sensory map development; axon guidance and synaptogenesis; molecular signaling pathways; neural circuit assembly

(This special issue belongs to the Section Molecular Neurobiology)

Endometriosis: Focusing on Molecular and Cellular Research, 2nd Edition

edited by

Alfonso Baldi

submission deadline 30 Aug 2026 | 2 articles | Viewed by 2858 | Submission Open

Keywords: endometriosis; reproductive system; endometrial cell; novel treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Discovery and Development of Functional Ingredients for Anti-Aging, Cognitive Enhancement and Skin Health

edited by

Sung-Joon Lee

and Jinbyung Park

submission deadline 30 Aug 2026 | 3 articles | Viewed by 1952 | Submission Open

Keywords: bioactive compounds; anti-aging; cognitive performance; skin health

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Human Endogenous Retrovirus Expression and Its Implications for Human Health and Disease

edited by

Luiz Henrique Da Silva Nali

submission deadline 30 Aug 2026 | 2 articles | Viewed by 1810 | Submission Open

Keywords: human endogenous retrovirus; HERVs genes expression; HERV families; autoimmune diseases; degenerative diseases; physiological function; gene expression modulation; inflammation; immune response; molecular biology

(This special issue belongs to the Section Molecular Microbiology)

Cytotoxicity, Antioxidant, and Anticancer Activity of Natural Products, 3rd Edition

edited by

Balik Dzhambazov

submission deadline 30 Aug 2026 | 3 articles | Viewed by 1467 | Submission Open

Keywords: natural products; anticancer activity; apoptosis; immunomodulation; free radicals; proliferation; phytomolecules; nanoparticles; drug delivery

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advanced Molecular Dynamics and Multiscale Modelling for Materials and Structures

edited by

Sandeep Kumar Singh

submission deadline 30 Aug 2026 | 1 articles | Viewed by 903 | Submission Open

Keywords: molecular dynamics simulations; atomistic modeling; multiscale modeling; high-entropy alloys; grain boundaries and defects; machine-learning interatomic potentials; computational materials science

(This special issue belongs to the Section Materials Science)

Latest Advances in Antiparasitic Agents

edited by Olga S. Koutsoni and

Maria Agallou

submission deadline 30 Aug 2026 | Viewed by 784 | Submission Open

Keywords: parasite genomics; parasite proteomics; metabolic pathways; parasite–host interactions; drug targets; mechanisms of drug resistance

(This special issue belongs to the Section Molecular Pharmacology)

Safety, Toxicity, and Therapeutic Potential of Natural Products and Complex Mixtures

edited by

Fotios Tekos

and Demetrios Kouretas

submission deadline 30 Aug 2026 | 1 articles | Viewed by 756 | Submission Open

Keywords: natural products; complex mixtures; toxicity; safety assessment; antioxidant activity; bioactivity; redox biology; nutraceuticals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Neurotransmitter Dysregulation in Brain Disease: Focus on Epilepsy and Its Comorbidities

edited by

Giuseppe Di Giovanni

submission deadline 30 Aug 2026 | Viewed by 447 | Submission Open

Keywords: neurotransmitter dysregulation; epilepsy; addiction; serotonin; GABA; molecular neuroscience; neuropharmacology; brain networks

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Biology of Placental Function and Pregnancy Complications

edited by

Yoshinori Moriyama

submission deadline 30 Aug 2026 | Viewed by 410 | Submission Open

Keywords: placenta; placental dysfunction; pregnancy complications; preeclampsia; fetal growth restriction; placental immunology

(This special issue belongs to the Section Molecular Biology)

Iron Metabolism in Health and Disease

edited by

Dariusz Szukiewicz

submission deadline 30 Aug 2026 | Viewed by 397 | Submission Open

Keywords: iron metabolism; iron homeostasis; hepcidin; anemia; iron overload

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Evolutionary Genetics of Pathogens

edited by Leonardo Gabriel Panunzi

submission deadline 30 Aug 2026 | Viewed by 362 | Submission Open

Keywords: pathogenicity; genome evolution; horizontal gene transfer; virulence factors; comparative genomics; pangenome analysis mobile genetic elements; computational biology; machine learning; host–pathogen interactions

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Mechanisms Fueling Glioblastoma Progression and Resistance: Emerging Therapeutic Opportunities

edited by

Anthony Lemarié

submission deadline 30 Aug 2026 | Viewed by 352 | Submission Open

Keywords: glioblastoma; cancer stem cells; radioresistance; chemoresistance; targeted therapies; tumor plasticity; tumor heterogeneity; invasion; immune escape

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Pathways and Emerging Biomarkers in Inflammatory Diseases

edited by

René Huber

submission deadline 30 Aug 2026 | Viewed by 348 | Submission Open

Keywords: inflammation; resolution of inflammation; inflammatory diseases; cancer; biomarker; molecular pathways; mediators; signal transduction; transcription factors; gene regulation; modifications

(This special issue belongs to the Section Molecular Immunology)

MiRNA Regulation in the Early PME/TME: The Role of Non-Cancer Cells and the ECM in Solid Tumours

edited by

Kurt Sartorius

submission deadline 30 Aug 2026 | 1 articles | Viewed by 345 | Submission Open

Keywords: microRNAs; early tumor microenvironment (TME); stromal/ECM interaction; vascularization; ECM remodelling; signalling pathways

(This special issue belongs to the Section Molecular Oncology)

Cardioprotective Mechanisms in Myocardial Ischemia

edited by Virginia Pérez and Verónica D’annunzio

submission deadline 30 Aug 2026 | Viewed by 334 | Submission Open

Keywords: myocardial ischemia; ischemia–reperfusion injury; cardioprotection; molecular signaling; oxidative stress; inflammation; cardiac remodeling; therapeutic targets; translational cardiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomarkers and Early Detection Strategies of Ovarian Tumors: 2nd Edition

edited by Lukasz Szafron

submission deadline 30 Aug 2026 | Viewed by 309 | Submission Open

Keywords: biomarker; ovarian cancer; borderline ovarian tumor; genetic variant; epigenetics; transciptomics; proteomics; metabolomics; ovarian tumor prevention; ovarian tumor treatment

(This special issue belongs to the Section Molecular Oncology)

New Advances in Graphene Nanocomposites

edited by Enrique Mejía-Ospino

submission deadline 30 Aug 2026 | Viewed by 277 | Submission Open

Keywords: graphene derivatives; interface chemistry; dispersion; molecular mechanisms

(This special issue belongs to the Section Molecular Nanoscience)

Advances in Traditional Tree Breeding for Growth, Adaptation, and Genetic Improvement

edited by Huiyu Li

submission deadline 30 Aug 2026 | Viewed by 221 | Submission Open

Keywords: tree breeding; genetic improvement; progeny testing; seed orchard; parental selection; growth adaptation; polyploid breeding; interspecific hybridization; forest genetics; climate resilience

(This special issue belongs to the Section Molecular Plant Sciences)

Protein Regulation and Targeted Therapeutics in Neurodegenerative Disorders

edited by

Niti Sharma

submission deadline 30 Aug 2026 | Viewed by 207 | Submission Open

Keywords: neurodegeneration; protein regulation; protein aggregation; small molecules; therapeutic approaches

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms Regulating Stress Tolerance in Ornamental Plants

edited by

Haizhen Zhang

submission deadline 30 Aug 2026 | Viewed by 185 | Submission Open

Keywords: ornamental plants; biotic stresses; abiotic stresses; signal transduction pathways; transcription factors; functional proteins; transcription; translation; post-translational modification

(This special issue belongs to the Section Molecular Plant Sciences)

Hormone Replacement Therapy

edited by

Marco Antonio Botelho

and

Raouf A. Khalil

submission deadline 31 Aug 2026 | 3 articles | Viewed by 38630 | Submission Open

Keywords: hormone replacement therapy; molecular insights; endocrine signaling; precision medicine; gene expression; epigenetics; non-coding RNAs; personalized regimens

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Dopamine, Histamine, Serotonin—Receptors, Ligands and Their Biological Role in Central Nervous System Diseases, 2nd Edition

edited by

Dorota Łażewska

and

Anna Stasiak

submission deadline 31 Aug 2026 | 6 articles | Viewed by 21701 | Submission Open

Keywords: biogenic amines (histamine, dopamine, serotonin); receptors; ligands; antagonist/inverse agonist; affinity; intrinsic activity; multitarget ligands; molecular modeling; CNS diseases; neurodegeneration; psychiatric disorders; pain; in vitro studies; in silico studies; in vivo studies

(This special issue belongs to the Section Molecular Neurobiology)

Novel Biomarkers and Emerging Therapeutic Targets for Breast and Gynecologic Cancers

edited by

Hisham Bahmad

submission deadline 31 Aug 2026 | 11 articles | Viewed by 17520 | Submission Open

Keywords: cancer; uterus; cervix; breast; ovary; endometrial cancer; ovarian cancer; cervical cancer; breast cancer; biomarkers; therapeutic target; personalized medicine; targeted therapy; molecular signatures; diagnosis; prognosis

(This special issue belongs to the Section Molecular Oncology)

Skin Microbiome and Skin Health: Molecular Interactions

edited by

Terenzio Cosio

submission deadline 31 Aug 2026 | 4 articles | Viewed by 14674 | Submission Open

Keywords: skin microbiota; human disease; human health; omics; microbiota–host interactions; microbiota manipulation; microbiota; virota; inflammatory diseases; dysbiosis

(This special issue belongs to the Section Molecular Immunology)

Neuroinflammation and Cellular Senescence in Brain Aging and Neurodegeneration: From Molecular Mechanisms to Therapeutic Applications

edited by Jordi Olloquequi and M. Emília Juan

submission deadline 31 Aug 2026 | 3 articles | Viewed by 10553 | Submission Open

Keywords: SASP; glial activation; age-related disorders; neurotherapeutics; molecular signaling

(This special issue belongs to the Section Molecular Neurobiology)

Exploring the Genetics in Rare Diseases: A Genomic Odyssey

edited by

Klaus Brusgaard

submission deadline 31 Aug 2026 | 3 articles | Viewed by 5867 | Submission Open

Keywords: novel discoveries in rare disorders; polygenic risk scores; mosaicism; protein interaction; tools utilized to engineer DNA; somatic variants; patient advocacy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Developmental Biology: Computational and Experimental Approaches, 3rd Edition

edited by

Mikhail P. Ponomarenko

submission deadline 31 Aug 2026 | 6 articles | Viewed by 4669 | Submission Open

Keywords: animal; plant; fungus; biological organization hierarchy; evolutionary limitations; fertilization; zygote; cell cycle; stem cell; meristem; cell layer; tissue; embryo; multicellular organism; ontogenesis; morphogenesis; life cycle; molecular mechanism; signal transduction; gene regulation; gene networks; cellular process; differentiation; migration; segmentation; high-resolution 3D-map; real-time in silico simulator; developmental hourglass; transcriptome ontogenetic switch; developmental abnormality; premature aging; neurodegeneration; tumorigenesis; atherogenesis; autoimmunity; induced pluripotent cell; wound healing; regeneration; assisted reproductive technologies; epigenetic reprogramming; predictive preventive personalized participatory (4P) medicine

(This special issue belongs to the Section Molecular Biology)

Anti-Inflammatory Strategies and Cell Models for Alzheimer’s Disease

edited by Sophia Lavrentiadou

submission deadline 31 Aug 2026 | 1 articles | Viewed by 4228 | Submission Open

Keywords: Alzheimer’s disease; neuroinflammation; anti-inflammatory strategies; cell models

(This special issue belongs to the Section Molecular Neurobiology)

Algae-Derived Bioactives: Key Molecular Interactions Govern High-Value Applications

edited by Evan Stephens and Kirsten Heimann

submission deadline 31 Aug 2026 | 4 articles | Viewed by 4147 | Submission Open

Keywords: microalgae; macroalgae; cyanobacteria; bioactive compounds; health and nutrition; algal food products; market analysis

(This special issue belongs to the Section Molecular Microbiology)

Genetic and Epigenetic Regulation of Ageing

edited by Hidekazu Yamada

submission deadline 31 Aug 2026 | 1 articles | Viewed by 3635 | Submission Open

Keywords: epigenetic clocks; biological resilience; DNA methylation; chromatin architecture; multi-omics integration; geroscience; cellular reprogramming; longevity interventions; immunosenescence; precision medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Ruminant Physiology: Digestion, Metabolism, and Endocrine System

edited by Rui Hu

submission deadline 31 Aug 2026 | 1 articles | Viewed by 3375 | Submission Open

Keywords: ruminant physiology; digestive health; metabolic regulation; endocrine signaling; rumen microbiome; nutrient partitioning; methane mitigation; epigenetic modulation; nutritional stress adaptation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Cardiovascular Diseases: From Molecular Diagnosis to Treatment

edited by

Li Wang

submission deadline 31 Aug 2026 | 2 articles | Viewed by 3369 | Submission Open

Keywords: cardiovascular diseases; molecular diagnosis; multi-omics approaches; liquid biopsies; molecular imaging; gene and cell therapies; nanomedicine; pharmacogenomics; targeted molecular therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Neuropeptides and Their GPCRs in the Neuroendocrine System

edited by

Hirotaka Sakamoto

submission deadline 31 Aug 2026 | 1 articles | Viewed by 3282 | Submission Open

Keywords: neuropeptides; G-protein-coupled receptors (GPCRs); neuroendocrine system; signal transduction; hypothalamus

(This special issue belongs to the Section Molecular Neurobiology)

Bioactivity and Mechanistic Insights of Plant-Derived Chemical Compounds

edited by

Mohammed Dalli

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2901 | Submission Open

Keywords: plant-derived compounds; bioactivity; mechanism of action; phytochemicals; pharmacology; natural products; molecular targets; ethnopharmacology; drug discovery; translational research

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Exploring Melatonin and Related Indolic Agents

edited by

Burkhard Poeggeler

submission deadline 31 Aug 2026 | 3 articles | Viewed by 2708 | Submission Open

Keywords: aging; antioxidant; bioenergetic agent; biological clock; immunomodulation; indole-3-propionic acid; indole-3-propionamide; melatonin; senescence; tryptophan

(This special issue belongs to the Section Molecular Pharmacology)

MicroRNA and Non-Coding RNA: From Basic Research to Potential Clinical Application—2nd Edition

edited by

Erika Cione

and

Diana Abrego-Guandique

submission deadline 31 Aug 2026 | 3 articles | Viewed by 2587 | Submission Open

Keywords: microRNA; non-coding RNA; gene regulation; biomarkers; RNA therapeutics; extracellular vesicles; microarray; NGS

(This special issue belongs to the Section Molecular Genetics and Genomics)

Sjogren's Disease: Multidimensional Perspectives on Pathogenesis, Clinical Manifestations, and Therapeutic Advancements (2nd Edition)

edited by

Xiang Lin

submission deadline 31 Aug 2026 | 5 articles | Viewed by 2563 | Submission Open

Keywords: Sjögren's disease; diagnosis; therapeutics; bioinformatics; pre-clinical; cytokine; lymphocytes; autoantibodies; exocrine glands

(This special issue belongs to the Section Molecular Immunology)

Role of Integrins in Cytokine Signaling

edited by

Yoshikazu Takada

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2324 | Submission Open

Keywords: integrins; cytokines; FGF1; CX3CL1; ternary-complex; antagonist; inside-out signaling; integrin-binding motif; cytokine-integrin crosstalk; ligand-induced activation

(This special issue belongs to the Section Molecular Biology)

Advanced In Vitro Systems for Mechanistic Toxicology

edited by

João Pedro Silva

and

Félix Carvalho

submission deadline 31 Aug 2026 | 3 articles | Viewed by 2255 | Submission Open

Keywords: mechanistic toxicology; organ-on-chip; microphysiological systems; human iPSC models; organoids; AI/ML modeling; multi-omics; high-content screening; 3D cell cultures

(This special issue belongs to the Section Molecular Toxicology)

Advances in the Molecular Diagnosis and Treatment of Neurodegenerative Diseases

edited by

Bruno Manadas

submission deadline 31 Aug 2026 | 1 articles | Viewed by 2211 | Submission Open

Keywords: neurodegenerative disorders; biomarkers; treatment; omics; systems biology

(This special issue belongs to the Section Molecular Neurobiology)

Nutrition, Inflammation and Chronic Kidney Diseases

edited by

Rodolfo A. Valtuille

submission deadline 31 Aug 2026 | 3 articles | Viewed by 2186 | Submission Open

Keywords: chronic kidney disease; nutrition; inflammation; bioimpedance; gut-kidney axis; uremic toxins; oxidative stress; protein-energy wasting; precision nutrition; biomarkers

(This special issue belongs to the Section Molecular Immunology)

Techniques and Applications of Forensic Molecular Biology: From Pathology to Clinical Practice

edited by

Angelo Montana

submission deadline 31 Aug 2026 | 1 articles | Viewed by 2165 | Submission Open

Keywords: biomarkers; immunohistochemistry; histopathology; forensic pathology; forensic toxicology; forensic biomarkers; toxicological biomarkers; neuropathology; mRNA; post-mortem interval; cerebral damage; in vitro, in vivo, and in silico models; hypoxic–ischemic brain injury; pregnancy biomarkers; vitality

(This special issue belongs to the Section Molecular Biology)

DNA Methylation Dynamics Due to Environmental Factors and in Human Diseases

edited by