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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genetic and Molecular Mechanisms of Obesity

edited by

Maria Elisabeth Street

and

Giuseppina Rosaria Umano

submission deadline 30 Dec 2025 | 3 articles | Viewed by 8374 | Submission Open

Keywords: obesity; insulin signal transduction; insulin sensitivity; co-morbidities; genetics; epigenetics; miRNAs; DNA methylation; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mitochondrial Biology and Human Diseases

edited by

Francesco Bruni

and

Paola Loguercio Polosa

submission deadline 30 Dec 2025 | 4 articles | Viewed by 8182 | Submission Open

Keywords: mitochondria; mitochondrial gene expression; bioenergetics; mitochondriopathies; human diseases

(This special issue belongs to the Section Molecular Biology)

Advances in Molecular Research on Autoimmune Diseases, 2nd Edition

edited by

Davide Cossu

submission deadline 30 Dec 2025 | 4 articles | Viewed by 7935 | Submission Open

Keywords: autoimmune markers; immunology; pathogenesis; immunogenetics; animal models; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Chromatin Remodelers as Players and Drivers in Pathological States

edited by Matteo De March

submission deadline 30 Dec 2025 | 3 articles | Viewed by 7395 | Submission Open

Keywords: protein structure/function; chromatin remodelers; DNA repair; oncogene/oncosuppressor; cancer

(This special issue belongs to the Section Molecular Biology)

IJMS 25th Anniversary: Updates and Progress on Bioactives and Nutraceuticals

edited by

Maurizio Battino

submission deadline 30 Dec 2025 | 6 articles | Viewed by 6940 | Submission Open

Keywords: natural products; bioactive; nutraceutical; nutrient; health; dietary; functional food; vitamins; phytochemicals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Non-small Cell Lung Cancer: From Molecular Mechanisms to Therapeutic Strategies

edited by

Lorenzo Belluomini

submission deadline 30 Dec 2025 | 3 articles | Viewed by 6666 | Submission Open

Keywords: NSCLC; predictive and prognostic biomarkers; immunotherapy; targeted therapy; special populations

(This special issue belongs to the Section Molecular Oncology)

Omics Technologies in Molecular Biology

edited by

Andrés J. Cortés

submission deadline 30 Dec 2025 | 3 articles | Viewed by 6590 | Submission Open

Keywords: omics technologies; genomics; transcriptomics; proteomics; metabolomics; lipidomics; phenomics; enviromics; big data; machine learning; molecular biology

(This special issue belongs to the Section Molecular Biology)

25th Anniversary of IJMS: Updates and Advances in Molecular Microbiology

edited by

Shu Yuan

submission deadline 30 Dec 2025 | 5 articles | Viewed by 6512 | Submission Open

Keywords: bacteria fungi; bacteriophages; microalgae; microbiome; gut microbiota; environmental microbiome; microbiome– brain– gut axis; virus– host interactions; emerging viruses re-emerging viruses; virus mutation; biofilm antimicrobial; SARS-CoV-2 (COVID-19)

(This special issue belongs to the Section Molecular Microbiology)

Plant and Environmental Interactions (Abiotic Stress)

edited by

Lixin Li

submission deadline 30 Dec 2025 | 5 articles | Viewed by 6362 | Submission Open

Keywords: stress response; signal transduction; metabolism and secondary metabolism; material/vesicle transportation; rhizospheric microorganism; interactions between plants and microorganisms

(This special issue belongs to the Section Molecular Plant Sciences)

Biophysical Perspectives on Bone Physiology and Pathology

edited by Atsuhiko Ichimura and Yohei Ueda

submission deadline 30 Dec 2025 | 1 articles | Viewed by 6248 | Submission Open

Keywords: bone formation; bone disorders; physiology; pathology; stem cells; osteoblasts; osteoclasts

(This special issue belongs to the Section Molecular Biophysics)

Molecular Pathogenesis and Therapies for Retinal and Optic Nerve Diseases

edited by

Toshiyuki Oshitari

submission deadline 30 Dec 2025 | 1 articles | Viewed by 6149 | Submission Open

Keywords: neurovascular unit; neurovascular cell death; neuroprotection; vasoprotection; regeneration; molecular and cellular pathologies; current and future therapies; drug delivery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Phenolic Accumulation and Application in Human Diseases

edited by

Izabela Grzegorczyk-Karolak

submission deadline 30 Dec 2025 | 3 articles | Viewed by 6123 | Submission Open

Keywords: antioxidant effects; anticancer/antiproliferative activity; anti-inflammatory activity; antimicrobial effects bioactive polyphenols; chemical identification of plant compounds; chemistry and mechanisms of action; health beneficial effect; medicinal plant; molecular targets; natural products; phytochemicals; structure– activity relationship

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Effect of Food-Derived Compounds on Brown Fat Cell Function

edited by

Nobuyuki Takahashi

submission deadline 30 Dec 2025 | 3 articles | Viewed by 5848 | Submission Open

Keywords: brown adipocyte; beige adipocyte; nutrients; food-derived components; thermogenesis; energy homeostasis; inflammation; obesity; diabetes; insulin resistance; metabolic syndrome; adipokines; lipid and carbohydrate metabolism

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms of Bone Development and Differentiation in Health and Disease

edited by

Cristina Sánchez-De-Diego

submission deadline 30 Dec 2025 | 3 articles | Viewed by 5750 | Submission Open

Keywords: bone differentiation; signaling pathways; bone diseases; bone formation; osteoblast; osteocyte; osteoclast

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Influence of Environmental Factors on Disease and Health Outcomes

edited by

Piotr Kaminski

submission deadline 30 Dec 2025 | 3 articles | Viewed by 5340 | Submission Open

Keywords: environmental factors; ecophysiological determinations; genetic predispositions; gene expression; defensive responses; pathophysiological abnormalities; lifestyle diseases; polymorphisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cirrhosis: From Molecular Mechanisms to Therapeutic Strategies

edited by

Hongqun Liu

submission deadline 30 Dec 2025 | 4 articles | Viewed by 5338 | Submission Open

Keywords: liver; fibrogenesis; cirrhosis; portal hypertension; complications; molecular mechanisms; pathway; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cellular Mechanisms and Signaling Pathways in Normal Tissue Repair and Fibrosis

edited by

Regina M. Day

and Jeffrey R. Koenitzer

submission deadline 30 Dec 2025 | 3 articles | Viewed by 4845 | Submission Open

Keywords: fibrosis; inflammation; senescence; myofibroblasts; Wnt/hedgehog; extracellular matrix; hedgehog; angiotensin II/transforming growth factor-beta; ephrins

(This special issue belongs to the Section Molecular Biology)

Reproductive Toxicity of Chemicals

edited by

Maria Laura Zenclussen

submission deadline 30 Dec 2025 | 5 articles | Viewed by 4743 | Submission Open

Keywords: reproductive health; fertility; anthropogenic chemicals; impaired fertility; reproductive toxicity; embryo; toxicants; hormone disruption; chemical exposure

(This special issue belongs to the Section Molecular Toxicology)

Immune Regulation and T Cell Dynamics

edited by Tatiana Akimova

submission deadline 30 Dec 2025 | 2 articles | Viewed by 4668 | Submission Open

Keywords: autoimmunity; T cells; FOXP3; Treg; regulatory T cells; transplantation; tolerance; T cell activation; exhaustion; T cell-mediated immunity; T cell immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Plant Natural Products for Human Health and Disease

edited by

Rumyana Simeonova

submission deadline 30 Dec 2025 | 2 articles | Viewed by 4601 | Submission Open

Keywords: medicinal plants; phytochemistry; bioactive compounds; metabolomics; proteomics; antioxidants; signal transduction; immunomodulation; phytopharmacology; ethnopharmacology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Role of Extracellular Matrix in Cancer

edited by

José M. Muñoz-Félix

submission deadline 30 Dec 2025 | 1 articles | Viewed by 4572 | Submission Open

Keywords: extracellular matrix; cancer; collagen; integrins; metastasis

(This special issue belongs to the Section Molecular Oncology)

Advances in Primary Nephropathies: Pathogenesis, Inflammatory Response and Advanced Treatments

edited by

Joan Torras-Ambròs

and Juliana Bordignon-Draibe

submission deadline 30 Dec 2025 | 2 articles | Viewed by 3730 | Submission Open

Keywords: primary glomerular diseases; membranous nephropathy; IgA nephropathy; glomerular inflammatory mechanisms; aberrantly glycosylated IgA1; galactose-deficient IgA1 (Gd-IgA1); alternative complement pathway; C5; factor B; factor D; APRIL; BAFF; phospholipase A2 receptor (PLA2R); thrombospondin type I domain-containing 7A (THSD7A); exostosins 1 and 2 (EXT1/2); neural epidermal growth factor-like 1 protein (NELL-1); semaphorin 3B (Sema3B); neural cell adhesion molecule 1 (NCAM1)

(This special issue belongs to the Section Molecular Immunology)

Heart Failure: From Molecular Mechanisms to Clinically Translational Innovations

edited by

Carmela Rita Balistreri

submission deadline 30 Dec 2025 | 1 articles | Viewed by 3426 | Submission Open

Keywords: heart failure; pathophysiology; cellular and molecular mechanisms; traditional biomarkers: limits and benefits; emerging molecular biomarkers; innovative therapies; i.e.; personalized therapies; targeted therapies; etc.; the application of artificial intelligence; multi-omics technologies; imaging innovative biomarkers; clinical translation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neurogenetic Disorders: Neurogenetics, Pathogenesis, and Gene Therapy

edited by

Paschalis Theotokis

submission deadline 30 Dec 2025 | 1 articles | Viewed by 3138 | Submission Open

Keywords: precision medicine; gene therapy; neurogenetics; rare monogenic diseases; inherited nervous system disorders; mitochondrial diseases (e.g.; LHON; MELAS); lysosomal storage disorders (e.g.; Tay– Sachs; Gaucher); hereditary neuropathies (e.g.; CMT; hATTR); motor neuron diseases (e.g.; SMA; ALS); spinocerebellar ataxias (e.g.; SCA); biomarkers in neurology

(This special issue belongs to the Section Molecular Neurobiology)

Advances in the Genetic Research on Psychiatric Disorders

edited by Lawrence Shih-Hsin Wu

submission deadline 30 Dec 2025 | 1 articles | Viewed by 3109 | Submission Open

Keywords: genetics; bipolar disorder; schizophrenia; major depressive disorder; autism; substance abuse; genomics

(This special issue belongs to the Section Molecular Neurobiology)

Insights into Mitochondrial Iron Metabolism: Connections to Cancer and Other Pathologies

edited by Michael Petronek

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2997 | Submission Open

Keywords: iron metabolism; mitochondrial iron; cellular homeostasis; iron– sulfur cluster biogenesis; heme synthesis; mitochondrial ferritin; cancer biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innate Immunity: New Insights into Genetic and Signaling Networks

edited by

Styliani Sarrou

submission deadline 30 Dec 2025 | 2 articles | Viewed by 2949 | Submission Open

Keywords: innate immunity; innate immune response; signaling pathways; genetic variations

(This special issue belongs to the Section Molecular Immunology)

The Emerging Role of Quantum Sciences and Radiation Biology in Biomedical Applications, 2nd Edition

edited by

Livio Giuliani

Pierre Madl

and

Nikolaj Sorgenfrei Blom

submission deadline 30 Dec 2025 | 2 articles | Viewed by 2949 | Submission Open

Keywords: quantum sciences; radiation biology; biomedical applications

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Neuroimmune Axis in Cancer and Inflammatory Diseases

edited by

Patrick Ming-Kuen Tang

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2898 | Submission Open

Keywords: neuro-immune axis; cancer progression; drug resistance; cancer therapy

(This special issue belongs to the Section Molecular Oncology)

Advances in the Pathogenesis and Treatment of Heart Failure

edited by

Wioletta Szczurek-Wasilewicz

and

Bożena Szyguła-Jurkiewicz

submission deadline 30 Dec 2025 | 2 articles | Viewed by 2527 | Submission Open

Keywords: heart failure; biomarkers; pathways of heart failure; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Artificial Intelligence: Applications in the Field of Immune-Mediated Inflammatory Diseases and Onco-Hematology

edited by

Giuseppe Murdaca

and

Sebastiano Gangemi

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2439 | Submission Open

Keywords: artificial intelligence; machine learning; immune-mediated diseases; cancers; hematological ma-lignancies

(This special issue belongs to the Section Molecular Immunology)

Recent Advances in Hypertension and Cardiovascular Disease: 2nd Edition

edited by

Edyta Zbroch

submission deadline 30 Dec 2025 | 2 articles | Viewed by 2414 | Submission Open

Keywords: hypertension; hypertension pathophysiology; hypertension molecular mechanisms; cardiovascular disease; cardiovascular pathophysiology; cardiovascular molecular mechanisms; cardiovascular biomarkers; heart failure; coronary artery disease; chronic kidney disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mechanisms of Diabetic Cardiomyopathy

edited by Martin Michel

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2381 | Submission Open

Keywords: diabetes; cardiomyopathy; animal models; novel treatments; pathophyiology; SGLT2 inhibitors; neprilysin inhibitors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innovative Strategies in Cancer Therapy

edited by

Paolo Coghi

and

Carmine Coluccini

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2368 | Submission Open

Keywords: tumor microenvironment; small molecules; IDO1 inhibition; checkpoint inhibitor therapy; adoptive T cell therapy; metabolic reprogram; resistance mechanisms; immune modulation; immune reconstitution; combination therapy; immunosuppression

(This special issue belongs to the Section Molecular Oncology)

Advances in Drug Delivery Systems: From Nanoparticles to Precision Medicine

edited by

Satya Prakash

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2358 | Submission Open

Keywords: polymer-based nanoparticles; lipid nanoparticles; PLGA and chitosan nano/microparticles for gene therapy; targeted drug delivery; nucleic acid-loaded nanoparticles; siRNA nanoparticles; nanoparticle-mediated mirna delivery; nanoparticles in cancer therapy; nanoparticles in vaccine design; nanoparticle-mediated gene therapy

(This special issue belongs to the Section Molecular Pharmacology)

New Advances in Cancer Stem Cell Research: 2nd Edition

edited by

Tomoyasu Sugiyama

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2182 | Submission Open

Keywords: cancer stem cell; biomarker; signaling; cancer-associated fibroblast; artificial intelligence; cell therapy; antibody therapy; cell therapy; gene expression

(This special issue belongs to the Section Molecular Oncology)

Plant Stress Biology

edited by Rui Li

submission deadline 30 Dec 2025 | 3 articles | Viewed by 2166 | Submission Open

Keywords: abiotic stress; biotic stress; stress response mechanisms; oxidative stress; phytohormones signaling; stress tolerance

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Advances in Anti-Cancer Drugs, 2nd Edition

edited by

Christiana Neophytou

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1998 | Submission Open

Keywords: combination therapy in cancer; small-molecule inhibitors in cancer; anti-cancer agents derived from natural sources; immunotherapy advances in cancer therapy; targeting metastatic dormancy; modulation of the tumor microenvironment; 3D model approaches in cancer research; predictive biomarkers for cancer chemoresistance

(This special issue belongs to the Section Molecular Oncology)

Advances in the Pathophysiology and Treatment of Eye Diseases

edited by

Georgios Panos

submission deadline 30 Dec 2025 | 2 articles | Viewed by 1833 | Submission Open

Keywords: ocular pathophysiology; eye diseases; molecular mechanisms; biomolecular pathways; therapeutic targets; translational ophthalmology; retinal degeneration; oxidative stress in ocular disorders; angiogenesis in eye diseases; neuroprotection in ophthalmology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Dietary Antioxidants in Human Health

edited by

Marika Cordaro

Roberta Fusco

and

Rosanna Di Paola

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1747 | Submission Open

Keywords: diet; functional food; oxidative stress; mitochondrial disfunction; human health; animal models; nutrition; molecular pathways; human pathology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Insights into Lectins

edited by Yuichiro Sato

submission deadline 30 Dec 2025 | 2 articles | Viewed by 1692 | Submission Open

Keywords: lectin; carbohydrate-binding specificity; virus; antiviral activity; cancer; anticancer activity; glycan-targeted therapy

(This special issue belongs to the Section Molecular Biology)

25th Anniversary of IJMS: Updates and Advances in Molecular Plant Sciences

edited by

Andrei Smertenko

submission deadline 30 Dec 2025 | 4 articles | Viewed by 1656 | Submission Open

Keywords: plant science; plant biochemistry; mechanisms; plant development; stress responses; plant physiology; genetics

(This special issue belongs to the Section Molecular Plant Sciences)

Cutting-Edge Advances in Natural Bioactive Compounds

edited by

Luisa M. P. F. Amaral

and

Romeu A. Videira

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1652 | Submission Open

Keywords: natural bioactive compounds; discovery and isolation; chemical characterization; biological activities; mechanisms of action; pharmaceuticals; nutraceuticals; agricultural applications; cosmetic innovations

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Stroke: Novel Molecular Mechanisms and Therapeutic Approaches

edited by Kang-Ho Choi

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1646 | Submission Open

Keywords: stroke; cerebrovascular disease; mechanisms; treatment; diagnosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neutrophil Extracellular Traps (NETs) in Human Disease: Mechanisms, Pathophysiology and Therapeutic Potential

edited by

Rachel Shukrun

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1412 | Submission Open

Keywords: neutrophil extracellular traps (NETs) ; NETosis ; inflammation ; cancer microenvironment ; autoimmune disease ; thrombosis ; molecular signaling ; innate immunity ; biomarkers ; targeted therapy

(This special issue belongs to the Section Molecular Immunology)

Hematologic Malignancies: From Molecular Pathology to Novel Therapeutics

edited by

Myrna Gloria Candelaria

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1334 | Submission Open

Keywords: pathogenesis; B-cell lymphoma regulation; epigenetics and hematology; bispecific antibodies in hematology; hematologic malignancies

(This special issue belongs to the Section Molecular Oncology)

Molecular Advances in Forensic Science: Integrating Innovation and Investigation

edited by

Aniello Maiese

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1251 | Submission Open

Keywords: DNA profiling; artificial intelligence; trace evidence analysis; immunohistochemical markers; molecular biology techniques; super-resolution microscopy; integrated forensic approach; new bioinformatics techniques; digital pathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Leptin Biology

edited by

Víctor Sánchez-Margalet

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1188 | Submission Open

Keywords: leptin; leptin expression; leptin receptor; leptin action

(This special issue belongs to the Section Molecular Biology)

Gene-Level Pharmacological Research on Natural Products

edited by

Wansu Park

submission deadline 30 Dec 2025 | Viewed by 901 | Submission Open

Keywords: natural products; gene-level pathways; pharmacological efficacy

(This special issue belongs to the Section Molecular Pharmacology)

Circulating Cell-Free Nucleic Acids and Cancers: 3rd Edition

edited by

Bruna Scaggiante

submission deadline 30 Dec 2025 | 1 articles | Viewed by 876 | Submission Open

Keywords: biological fluids; cancer; cancer biomarkers; cfDI; cfDNA; cfNA; copy number variation; ctDNA; ddPCR; disease-free survival; epigenetic; epigenetic sequencing; exosome; extracellular vesicle; genotyping; liquid biopsy; miRNA; mRNA; mutation; ncRNA; next-generation sequencing; overall survival; progression-free survival; recurrence-free survival; whole-exome sequencing

(This special issue belongs to the Section Molecular Oncology)

Displaying special issue 801-850 on page 17 of 69.

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