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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Insights of Metabolomics
edited by
submission deadline 31 Oct 2026 | Viewed by 232 | Submission Open
Keywords: pathway; metabolites; metabolomics; LC; GC; NMR; mechanism; statistical analysis
(This special issue belongs to the Section Biochemistry)
Targeted Lipidomics Approaches in Cardiometabolic Diseases: From Sample Preparation to Data Interpretation for Combined Multiomics Analysis submission deadline 31 Oct 2026 | Viewed by 226 | Submission Open
Keywords: biomarkers; cardiometabolic diseases; cell signaling; lipids; lipid metabolism; lipoproteins; methodology; multiomics; therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Nanotechnology in Precision Medicine for Pancreatic Cancer
edited by Virendar Kumar
submission deadline 31 Oct 2026 | Viewed by 223 | Submission Open
Keywords: nanotechnology; precision medicine; pancreatic cancer; pancreatic ductal adenocarcinoma (PDAC); tumor microenvironment; desmoplasia / stromal barrier; targeted drug delivery; stimuli-responsive nanocarriers; theranostics; nucleic acid therapeutics (siRNA / mRNA); cancer immunotherapy; translational nanomedicine/clinical translation
(This special issue belongs to the Section Molecular Nanoscience)
Multi-Omics and AI-Driven Discovery of Abiotic Stress Resilience in Crops
edited by
submission deadline 31 Oct 2026 | Viewed by 221 | Submission Open
Keywords: genomics; pangenome; abiotic stress; multi-omics; artificial intelligence; climate extremes; predictive breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Inherited Metabolic Disorders: Genetic Insights and Therapeutic Strategies
edited by and Kristiane Michelin-Tirelli
submission deadline 31 Oct 2026 | Viewed by 221 | Submission Open
Keywords: inherited metabolic disorders; animal models; biomarkers; clinical laboratory techniques; tandem mass spectrometry; high-throughput nucleotide sequencing; cell- and tissue-based therapy; genetic therapy; enzyme replacement therapy; precision medicine
(This special issue belongs to the Section Molecular Genetics and Genomics)
Effects of Oxidative Stress and Mitochondrial Function on Lifespan
edited by Ines Sanchez-Roman
submission deadline 31 Oct 2026 | Viewed by 221 | Submission Open
Keywords: aging; mitochondrial dysfunction; oxidative stress; genomic instability; longevity; aging-associated diseases; interventions; reactive oxygen species
(This special issue belongs to the Section Molecular Biology)
Recent Research Progress in Metal Complexes
edited by
submission deadline 31 Oct 2026 | Viewed by 221 | Submission Open
Keywords: coordination chemistry; metal–ligand complexes; ligand design and synthesis; d-block and f-block metals; spectroscopic and analytical characterizations; computational chemistry and theoretical investigations; photochemical properties and optoelectronic applications; metal complexes as catalysis; bioinorganic and medicinal applications
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Spatial Multi-Omics: From Molecular Maps to Precision Medicine
edited by
submission deadline 31 Oct 2026 | Viewed by 221 | Submission Open
Keywords: multi-omics; spatial multi-omics; cell-type-specific molecular alterations; tissue microenvironments; molecular diagnostics; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Reparative Therapeutic Strategies in Neurodegenerative Diseases
edited by and Amir Hadanny
submission deadline 31 Oct 2026 | Viewed by 220 | Submission Open
Keywords: neurodegeneration; cell death signaling; oxidative stress; mitochondrial dysfunction; brain repair
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Studies on Natural Products: Anti-Inflammatory, Immune Response, and Anti-Bacterial Activities
edited by Hicham Wahnou
submission deadline 31 Oct 2026 | Viewed by 220 | Submission Open
Keywords: natural products; anti-inflammatory; immune response; antibacterial; molecular mechanisms; phytochemicals; immunomodulation; probiotics; prebiotics; synbiotics
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Biochemical Functions and Therapeutic Potential of Dietary Bioactive Peptides
edited by
submission deadline 31 Oct 2026 | Viewed by 219 | Submission Open
Keywords: bioactive peptides; molecular mechanisms; structure–activity relationship; peptidomics; functional foods; by-product valorization; antioxidant activity; bioavailability; cellular signaling; multidisciplinary approaches
(This special issue belongs to the Section Biochemistry)
Acute Lymphoblastic Leukemia (ALL): From Molecular Drivers to Therapeutic Innovation
edited by Carmen Maldonado-Bernal
submission deadline 31 Oct 2026 | Viewed by 219 | Submission Open
Keywords: acute lymphoblastic leukemia; minimal residual disease; molecular drivers; genetic drivers treatment approaches; immunotherapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Modifications Driven by Parasite–Host Interplay submission deadline 31 Oct 2026 | Viewed by 217 | Submission Open
Keywords: pathogens; molecular pathogenesis; immunomodulation; evasion; host defense mechanisms; parasitic signaling
(This special issue belongs to the Section Molecular Biology)
Bioactive Foods in Metabolic Disease: Mechanisms and Therapeutic Opportunities
edited by Salima Akter and
submission deadline 31 Oct 2026 | Viewed by 214 | Submission Open
Keywords: metabolic diseases; medicinal foods; nutrient signaling; functional nutrition; insulin resistance; metabolomics; phytochemicals; precision nutrition; gut microbiome
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Research on the Immunomodulatory Role of Macrophages
edited by
submission deadline 31 Oct 2026 | Viewed by 212 | Submission Open
Keywords: disease models; immunometabolism; extracellular vesicles; biomarkers; inflammation; therapeutic targets; pregnancy
(This special issue belongs to the Section Molecular Immunology)
Epigenetic Regulation in Health and Disease: From Molecular Mechanisms to Clinical Applications
edited by
submission deadline 31 Oct 2026 | Viewed by 211 | Submission Open
Keywords: epigenetic modifications; DNA methylation; histone modifications; chromatin remodeling; non-coding RNAs; environmental epigenetics; development and aging; disease epigenetics; translational epigenetics; precision medicine
(This special issue belongs to the Section Molecular Genetics and Genomics)
Computing Methods to Improve the Polymerization/Performance of Biopolymers and Their Composites
edited by
submission deadline 31 Oct 2026 | Viewed by 211 | Submission Open
Keywords: biopolymers; PLA; PHA; PHB; molecular dynamic; DFT; catalyst; simulation; calculation; artificial intelligence
(This special issue belongs to the Section Materials Science)
Pharmacological Perspectives for Natural Products
edited by Ilsamar Mendes Soares
submission deadline 31 Oct 2026 | Viewed by 209 | Submission Open
Keywords: natural products; pharmacology; bioactivity; molecular targets; ethnopharmacology
(This special issue belongs to the Section Molecular Pharmacology)
Autophagy in Aging: Molecular Mechanisms and Therapeutic Implications submission deadline 31 Oct 2026 | Viewed by 208 | Submission Open
Keywords: autophagy; aging; mitophagy; molecular mechanisms
(This special issue belongs to the Section Molecular Biology)
Progress in Functional Genomics and Regulation of Gene Expression
edited by Alejandro Bravo-Patino
submission deadline 31 Oct 2026 | Viewed by 208 | Submission Open
Keywords: functional genomic; gene regulation; gene interactions; biomarkers; differential gene expression; epigenetics and gene regulation
(This special issue belongs to the Section Molecular Genetics and Genomics)
Congenital Heart Disease: From Molecular Mechanisms to Therapeutic Strategies submission deadline 31 Oct 2026 | Viewed by 204 | Submission Open
Keywords: genetics; gene expression; epigenetics; non-coding RNAs; omics data analysis; cardiogenesis; environmental risk factors; disease marker
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Adrenal Endocrinology: Molecular Insights and Emerging Trends
edited by , and Francesco Circosta
submission deadline 31 Oct 2026 | Viewed by 202 | Submission Open
Keywords: adrenal disorders; steroid profiling; multi-omics
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Immunology and Defenses: Oral and Periodontal Health
edited by Evangelos Papathanasiou
submission deadline 31 Oct 2026 | Viewed by 200 | Submission Open
Keywords: periodontal disease; immune response; host defense; inflammation; immune regulation
(This special issue belongs to the Section Molecular Immunology)
The Multiple Roles of RNA and RNases
edited by
submission deadline 31 Oct 2026 | Viewed by 199 | Submission Open
Keywords: RNA; RNase; diagnosis markers; drug design; cell signalling; immunology; infection; cancer; structural biology; RNA-binding proteins; RNA recognition patterns; RNA catalysis
(This special issue belongs to the Section Molecular Biology)
High Fat Diet Metabolism and Diseases: 2nd Edition submission deadline 31 Oct 2026 | Viewed by 199 | Submission Open
Keywords: diet; fat; high-fat diets; obesity; NAFLD; metabolism; reproductive system; lungs; pathology
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Recent Advances in Therapeutic Targets for Musculoskeletal Tumors
edited by Japneet Kaur
submission deadline 31 Oct 2026 | Viewed by 196 | Submission Open
Keywords: musculoskeletal tumors; sarcoma; bone metastasis; tumor microenvironment; targeted therapy; immunotherapy; biomarkers; drug resistance; signaling pathways; cancer biology
(This special issue belongs to the Section Molecular Oncology)
Insights on the Efficacy and Safety of Cytotoxic Agents in Lung Cancer submission deadline 31 Oct 2026 | Viewed by 194 | Submission Open
Keywords: lung cancer; cytotoxic agents; chemotherapy; antibody–drug conjugates; non-small-cell lung cancer; small-cell lung cancer; drug safety; platinum-based chemotherapy; drug resistance
(This special issue belongs to the Section Molecular Oncology)
Advances in Gene and Nucleic Acid-Based Therapeutics: From Molecular Innovations to Potential Misuse
edited by
submission deadline 31 Oct 2026 | Viewed by 194 | Submission Open
Keywords: gene therapy; nucleic acid therapeutics; mRNA therapeutics; lipid nanoparticles (LNPs); genome editing (CRISPR/Cas); gene delivery systems; cell therapy; pharmacokinetics and safety; gene doping; detection methods
(This special issue belongs to the Section Molecular Genetics and Genomics)
Environmental Genomics and Epigenomics: Response, Development and Disease
edited by
submission deadline 31 Oct 2026 | Viewed by 193 | Submission Open
Keywords: developmental toxicology; environmental genomics; environmental pollutants; gene–environment interaction; integrated omics; transgenerational effects; environmental health; risk assessment
(This special issue belongs to the Section Molecular Genetics and Genomics)
Functional Emulsion Systems in Pharmaceutical Science: Stability, Drug Delivery, and Biocatalytic Applications
edited by
submission deadline 31 Oct 2026 | Viewed by 192 | Submission Open
Keywords: emulsion systems; emulsion stability; drug delivery; pharmaceutical formulations; surfactants; supports; enzyme immobilization; biocatalysis; chiral drugs; kinetic resolution; enantioselective synthesis; lipolytic activity
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Biology of Histone Demethylases
edited by
submission deadline 31 Oct 2026 | Viewed by 191 | Submission Open
Keywords: histone demethylase and transcriptional regulation; histone demethylase function; histone demethylase and cancer; histone methylation and genotoxic damage; histone demethylase expression
(This special issue belongs to the Section Molecular Biology)
Nutrient Sensing in Human Metabolic Disorders
edited by
submission deadline 31 Oct 2026 | Viewed by 191 | Submission Open
Keywords: nutrient sensing; obesity; insulin resistance; type 2 diabetes; metabolic disease; adipokines; AMPK; mTOR; inflammation; oxidative stress
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Protein S in Coagulation, Inflammation, and Cancer
edited by
submission deadline 31 Oct 2026 | Viewed by 189 | Submission Open
Keywords: Protein S; hemostasis; anticoagulation; inflammation; cancer biology; thrombotic disorders; biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Oncology)
Application of Genome Editing in Crop Improvement for Abiotic Stress Resistance
edited by
submission deadline 31 Oct 2026 | Viewed by 188 | Submission Open
Keywords: genome editing; crop improvement; abiotic stress resistance; CRISPR-Cas9; crop breeding; food security; agricultural sustainability
(This special issue belongs to the Section Molecular Plant Sciences)
The Role of Protein Kinase in Health and Diseases, 2nd Edition
edited by
submission deadline 31 Oct 2026 | Viewed by 187 | Submission Open
Keywords: protein kinases; phosphorylation; cancer; neurological disorder; targeted therapies; meta-bolic diseases
(This special issue belongs to the Section Molecular Biology)
Advances in Molecular Biomaterials for Pollutants Removal
edited by Jarosław Chwastowski and
submission deadline 31 Oct 2026 | Viewed by 187 | Submission Open
Keywords: biomaterials; biosorption; biodegradation; microorganisms; isotherm and kinetic modeling; organic sorbents
(This special issue belongs to the Section Materials Science)
Nano–Plant Interactions: Molecular Mechanisms and Applications in In Vitro Systems
edited by
submission deadline 31 Oct 2026 | Viewed by 186 | Submission Open
Keywords: nano–plant interactions; nanomaterials; nanoparticle uptake; plant tissue cultures; nanoparticle-induced molecular responses
(This special issue belongs to the Section Molecular Plant Sciences)
Natural Products and Functional Biomaterials in Wound Healing and Cancer Treatment
edited by Shaik Nyamathulla
submission deadline 31 Oct 2026 | Viewed by 183 | Submission Open
Keywords: cancer; wound healing; biomaterials; diabetes; cytokines
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Overcoming Membrane Protein Challenges with Computational Methods
edited by
submission deadline 31 Oct 2026 | Viewed by 180 | Submission Open
Keywords: membrane protein; structural and functional properties; computational approaches; molecular dynamics; free energy calculations; computational docking and drug design approaches
(This special issue belongs to the Section Macromolecules)
Discovery, Synthesis, and Therapeutic Applications of Enzyme Inhibitors submission deadline 31 Oct 2026 | Viewed by 179 | Submission Open
Keywords: cardiovascular diseases; neuroinflammation; neurodegeneration; cancer; clinical trial
(This special issue belongs to the Section Biochemistry)
Molecular Research and Insight in Plant Genetic Breeding
edited by
submission deadline 31 Oct 2026 | Viewed by 179 | Submission Open
Keywords: plant genetic breeding; crop genomics; gene editing; molecular markers; functional genomics; germplasm enhancement; omics breeding; crop improvement
(This special issue belongs to the Section Molecular Plant Sciences)
Beyond the Single Gene: The Polygenic Architecture of Drug Response submission deadline 31 Oct 2026 | Viewed by 176 | Submission Open
Keywords: pharmacogenomics; pharmacogenetics; polygenic architecture; polygenic risk scores; precision medicine; adverse drug reactions; epistasis/gene–gene interactions; genomic biomarkers
(This special issue belongs to the Section Molecular Pharmacology)
Nanobodies and Monoclonal Antibodies: Epitope, Structure and Neutralization
edited by David Vance
submission deadline 31 Oct 2026 | Viewed by 176 | Submission Open
Keywords: monoclonal antibody; nanobody; antibody-antigen interactions; epitope mapping; neutralizing mechanisms; structural biology; vaccine design
(This special issue belongs to the Section Molecular Nanoscience)
Ion Channel in Physiology
edited by Isaac E. García
submission deadline 31 Oct 2026 | Viewed by 175 | Submission Open
Keywords: ion channels; channel gating mechanisms; structure–function relationships; electrophysiology; cryo-electron microscopy (cryo-EM); connexin hemichannels and gap junctions; pannexin channels; ion transporters; cell signaling and homeostasis; channelopathies
(This special issue belongs to the Section Molecular Biophysics)
Bioactive Lipid Signaling in Cardiovascular and Metabolism-Associated Diseases
edited by
submission deadline 31 Oct 2026 | Viewed by 170 | Submission Open
Keywords: bioactive lipids; inflammation; lipid metabolism; lipid signaling pathways; cardiovascular and metabolism-associated diseases; cellular phenotype; lipid receptors; cardiovascular treatments; lipidomics
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Respiratory Tract Infections: Molecular Pathogenesis, Advanced Diagnostics, and Translational Strategies
edited by Roy Rillera Marzo
submission deadline 31 Oct 2026 | Viewed by 164 | Submission Open
Keywords: respiratory tract infections; host–pathogen interactions; molecular diagnostics; genomics and proteomics; antimicrobial resistance; biomarkers; immune response; precision medicine; translational research; infectious disease epidemiology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Functional Materials for Environmental Remediation and Ecosystem Sustainability
edited by Chenyu Wang
submission deadline 31 Oct 2026 | Viewed by 159 | Submission Open
Keywords: functional nanomaterials; environmental remediation; water pollution control; self-assembled systems; ecosystem sustainability; advanced adsorbents; catalysis and oxidation; polyphosphate-based materials; green chemistry; environmental sensors
(This special issue belongs to the Section Molecular Nanoscience)
New Predictive Biomarkers for Ovarian Cancers submission deadline 31 Oct 2026 | Viewed by 151 | Submission Open
Keywords: ovarian cancer; biomarkers; chemorresistance; nanotechnology; ovarian cancer signaling; metabolic plasticity in ovarian cancer; omics in ovarian cancer
(This special issue belongs to the Section Molecular Oncology)
Aging, Regeneration and Stem Cell Biology of Fascial Tissue
edited by and
submission deadline 31 Oct 2026 | Viewed by 108 | Submission Open
Keywords: fascia; aging; regeneration; stem cells; extracellular matrix; fibrosis; mechanobiology; mesenchymal stem cells; tissue repair; myofascial pain
(This special issue belongs to the Section Molecular Biology)
Spike Protein Receptor submission deadline 15 Nov 2026 | Viewed by 311 | Submission Open
Keywords: spike protein; receptor binding; ACE2 interaction; viral entry; structural virology; immune recognition; antibody and IgA epitopes; variant transmissibility; receptor-blocking therapeutics
(This special issue belongs to the Section Molecular Biophysics)
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