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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Study of the Molecular Mechanisms Underlying the Involvement of Viruses in the Progression of Autoimmune Diseases

edited by

Marco Miceli

submission deadline 28 Feb 2027 | Viewed by 384 | Submission Open

Keywords: multiple sclerosis; central nervous system; autoimmune; genetic and environmental factors; herpesviruses; CMV; immunopathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Phenotype-Targeted Nanomedicine: Navigating Multiscale Biological Barriers in the 2026 Clinical Era

edited by

Athina Angelopoulou

submission deadline 28 Feb 2027 | Viewed by 383 | Submission Open

Keywords: nanomedicine; nanotherapeutic; nanobiomaterials; TME

(This special issue belongs to the Section Molecular Nanoscience)

Pathophysiology of Preeclampsia and Gestational Diabetes: Shared Molecular Mechanisms in Pregnancy-Related Disorders

edited by Tamara Nikolic Turnic

submission deadline 28 Feb 2027 | Viewed by 373 | Submission Open

Keywords: preeclampsia; molecular mechanism; mechanism of preventive/curative strategies; placenta dysfunction

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular, Cellular Mechanisms and Pathophysiology of Glioblastoma

edited by Agnieszka Rusak

submission deadline 28 Feb 2027 | Viewed by 372 | Submission Open

Keywords: glioblastoma; targeted terapy; molecular patchway; drug carriers; biomaterials

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Design of Therapeutic Small-Molecular Blockers Against Channel Proteins

edited by Kingshuk Basu

submission deadline 28 Feb 2027 | Viewed by 369 | Submission Open

Keywords: channel proteins; channel blockers; membrane protein; drug design; drug screening; electrophysiology

(This special issue belongs to the Section Molecular Pharmacology)

The Role of Tubulin in Human Diseases

edited by Souvik Banerjee

submission deadline 28 Feb 2027 | Viewed by 368 | Submission Open

Keywords: tubulin; microtubules; medicinal chemistry; chemotherapy; drug discovery and design; drug target; cancer; chemoresistance; microtubule-targeting agents

(This special issue belongs to the Section Molecular Biology)

Natural Antioxidants: Molecular Mechanisms, Formulations and Therapeutic Perspectives

edited by

Lavinia Anamaria Purza

submission deadline 28 Feb 2027 | Viewed by 364 | Submission Open

Keywords: natural antioxidants; oxidative stress; redox signaling; polyphenols; reactive oxygen species; bioactive compounds; nutraceuticals; phytochemicals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Nutrition for Muscle Health and Metabolism

edited by

Hira Shakoor

submission deadline 28 Feb 2027 | Viewed by 359 | Submission Open

Keywords: nutrition; skeletal muscle; muscle metabolism; mitochondrial function; insulin sensitivity; myokines; metabolic health; metabolic disease

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Research on the Antioxidant, Anti-Inflammatory, and Antibacterial Activities of Natural Products

edited by

Carmen Lizette Del Toro Sánchez

and

Ariadna Thalia Bernal-Mercado

submission deadline 28 Feb 2027 | Viewed by 357 | Submission Open

Keywords: natural bioactive compounds; antioxidant mechanisms; anti-inflammatory pathways; antibacterial activity; agro-industrial byproducts; molecular docking; structure–activity relationship (SAR); omics technologies; drug delivery systems; nanobiotechnology; bioavailability

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms Underlying the Pathogenesis and Treatment of Gastrointestinal Disorders

edited by

Andrzej Pławski

submission deadline 28 Feb 2027 | Viewed by 344 | Submission Open

Keywords: gastrointestinal disorders; molecular mechanisms; diagnosis; treatment; precision medicine; biomarkers; gastrointestinal cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Dementia and Application of Biomarkers

edited by

Teresa Juárez-Cedillo

submission deadline 28 Feb 2027 | Viewed by 343 | Submission Open

Keywords: Alzheimer's; diagnosis; biological marker; protein; therapeutic target

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Spinal Cord Injury: A Comprehensive Approach to Pathophysiology, Treatment, and Recovery

edited by Raúl Silva Garcia and Elisa García-Vences

submission deadline 28 Feb 2027 | Viewed by 343 | Submission Open

Keywords: spinal cord injury; neuroprotection; inflammation; therapy; pathophysiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Phenolic Compounds as Adjunct Therapy in Cardiometabolic Disorders

edited by

Dalia Marija Kopustinskiene

submission deadline 28 Feb 2027 | Viewed by 340 | Submission Open

Keywords: phenolic compounds; cardiovascular diseases; metabolism; diabetes; obesity; hypertension; mitochondria; oxidative stress; gut microbiota; inflammation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Plant Secondary Metabolites and Their Regulatory Mechanisms

edited by

Daniela Trono

submission deadline 28 Feb 2027 | Viewed by 338 | Submission Open

Keywords: secondary metabolites; plant growth and development; response to biotic and abiotic stresses; biosynthesis and degradation; gene and enzyme regulation; metabolic engineering; omics approaches

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Calcium Signaling: Physiological Roles and Implications for Disease

edited by

Adán Dagnino-Acosta

and

Luis Castro-Sánchez

submission deadline 28 Feb 2027 | Viewed by 336 | Submission Open

Keywords: calcium signaling; intracellular calcium; calcium homeostasis; calcium channels; muscle physiology; signal transduction; calcium-related diseases; mitochondrial calcium; genetic control of calcium signaling

(This special issue belongs to the Section Molecular Biology)

Advances in Molecular Research of Supramolecular Polymers

edited by

Attila Bende

submission deadline 28 Feb 2027 | Viewed by 333 | Submission Open

Keywords: supramolecular polymers; supramolecular aggregates; molecular self-assemblies; photochemistry and photophysics of molecular materials

(This special issue belongs to the Section Materials Science)

Microbes in Obstetrics: Current Importance of Ascending Bacterial Infection (ABI)

edited by Alfredo Ovalle and Enrique Oyarzun

submission deadline 28 Feb 2027 | Viewed by 328 | Submission Open

Keywords: ascending bacterial infection (ABI); vaginal dysbiosis; spontaneous preterm birth (sPTB); group B streptococcus (GBS); fetal inflammatory response syndrome (FIRS); microbiomics; maternal immunology; cervical insufficiency

(This special issue belongs to the Section Molecular Microbiology)

Advances in Neuropharmacology: From Molecular Design to Preclinical Models

edited by

Jana Tchekalarova

and Miroslav A. Rangelov

submission deadline 28 Feb 2027 | Viewed by 327 | Submission Open

Keywords: neuropharmacology; drug discovery; molecular modeling; preclinical models

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Genetics of Arthritis

edited by

Bouchra Edderkaoui

submission deadline 28 Feb 2027 | Viewed by 324 | Submission Open

Keywords: arthritis; genetic susceptibility; genome-wide association studies; population genetics; genetic loci; epigenetics; gene-environmental interaction; polygenic risk scores; transcriptomics; single-cell sequencing; genomics; rare variants; polymorphisms; candidate genes; autoimmunity genetics; genetics of cartilage; degeneration, regeneration, and inflammatory pathways; genetic biomarkers; pharmacogenomics; functional genomics; precision medicine/ personalized treatments

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Research in Postharvest Biology

edited by Hua Zhang

submission deadline 28 Feb 2027 | Viewed by 322 | Submission Open

Keywords: postharvest biology; molecular regulation; plant hormone signaling; gas signaling molecules; ripening-related genes; transgenic technology; postharvest quality preservation

(This special issue belongs to the Section Molecular Plant Sciences)

Vitamin D in Reproductive Disorders: Determinants, Metabolism, and Downstream Biological Mechanisms

edited by

Eugenia Mata-Greenwood

submission deadline 28 Feb 2027 | Viewed by 316 | Submission Open

Keywords: vitamin D; perinatal corticosteroids; placental insufficiency; intrauterine growth restriction; cortisol metabolism

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Coordination Architectures for Next-Generation Chemical Sensors: Metal Complexes, Coordination Polymers and MOFs

edited by

Tamara Basova

and

Darya Klyamer

submission deadline 28 Feb 2027 | Viewed by 310 | Submission Open

Keywords: metal complexes; coordination polymers; MOFs

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Exploring Molecular Mechanisms of Lens Development and Growth

edited by

Michael L. Robinson

submission deadline 28 Feb 2027 | Viewed by 310 | Submission Open

Keywords: lens development; lens fiber cell differentiation; organelle degradation; transcriptional regulation; signal transduction; lens regeneration; chromatin remodeling; ocular development

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Treatments of Prostate Cancer

edited by

Sara Merler

submission deadline 28 Feb 2027 | Viewed by 306 | Submission Open

Keywords: prostate cancer; molecular mechanisms; tumor progression; androgen receptor signaling; genetic and epigenetic alterations; biomarkers; tumor microenvironment; therapeutic resistance; targeted therapies

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Biomarkers of Renal Injury: Bridging the Gap Between Micro-Environment Damage and Clinical Diagnosis

edited by Alexandre Braga Libório

submission deadline 28 Feb 2027 | Viewed by 302 | Submission Open

Keywords: renal injury; molecular biomarkers; AKI-CKD transition; regulated cell death; precision nephrology; renal microenvironment; epigenetics; tubulointerstitial fibrosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Effects of Diets and Environmental Pollutants on the Intestine and Liver: A Molecular Perspective

edited by

Aneta Sokal-Dembowska

submission deadline 28 Feb 2027 | Viewed by 301 | Submission Open

Keywords: gut–liver axis; diet; environmental pollutants; molecular mechanisms; gut microbiota; intestinal barrier; liver disease; inflammation; oxidative stress; epigenetics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Extracellular Vesicles as Drivers of Cancer Therapy Resistance: Mechanistic Insights and Emerging Therapeutic Strategies

edited by Abraham Pedroza-Torres

submission deadline 28 Feb 2027 | Viewed by 298 | Submission Open

Keywords: extracellular vesicles; exosomes; cancer resistance; tumor microenvironment; biomolecule transfer

(This special issue belongs to the Section Molecular Oncology)

Molecular Progression of Gut Microbiota—2nd Edition

edited by

Emina Pustijanac

submission deadline 28 Feb 2027 | Viewed by 297 | Submission Open

Keywords: gut microbiota; microbiome; differences in gut microflora; molecular techniques; gut microbiota’s role and composition; healthy state; dysbiosis

(This special issue belongs to the Section Molecular Microbiology)

Advances in Biomedical and Tissue Engineering Strategies to Cross the Blood–Brain Barrier for Next-Generation Treatments Against Neurodegenerative Diseases, 2nd Edition

edited by Livia La Barbera

submission deadline 28 Feb 2027 | Viewed by 290 | Submission Open

Keywords: neurodegenerative diseases; Alzheimer’s disease; CNS; blood–brain barrier; drug delivery systems; nanocarriers; nanomedicine; tissue engineering; theranostics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Backend Databases in Pharmacogenomics and Genome Informatics

edited by Alireza Tafazoli

submission deadline 28 Feb 2027 | Viewed by 289 | Submission Open

Keywords: pharmacogenomics; genome informatics; genomic databases; variant interpretation; pharmacogene nomenclature; genotype-to-phenotype translation; clinical decision support; application programming interfaces; FAIR genomic data

(This special issue belongs to the Section Molecular Informatics)

Current Issues in Natural Product Bioactivity and Drug Discovery

edited by

Bey-Hing Goh

Jun-Ho Kim

and Pei Lou Wong

submission deadline 28 Feb 2027 | Viewed by 284 | Submission Open

Keywords: natural products; drug discovery; bioprospecting; pharmacology; multi-omics; molecular biology; bioactivity; advanced screening; emerging technologies; artificial intelligence

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms of Protein Inhibition and Metabolism

edited by Song Wang

submission deadline 28 Feb 2027 | Viewed by 282 | Submission Open

Keywords: protein inhibition; metabolism; computational chemistry; molecular modeling; therapeutic targets

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Obesity and Its Associated Diseases: Molecular and Metabolic Pathways

edited by Verónica J. Miksztowicz

submission deadline 28 Feb 2027 | Viewed by 279 | Submission Open

Keywords: obesity; dietary patterns; metabolic pathways; adipose tissue dysfunction; chronic low-grade inflammation; insulin resistance; mitochondrial dysfunction; oxidative stress; adipokine signaling; inter-organ crosstalk

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Non-Mammalian Models in Toxicology Research on Environmental Pollutants

edited by

Ida Ferrandino

and

Giovanni Scillitani

submission deadline 28 Feb 2027 | Viewed by 277 | Submission Open

Keywords: environment; pollution; pollutants; contaminants; non-mammalian models; animals; toxicology; invertebrates; lower vertebrates

(This special issue belongs to the Section Molecular Toxicology)

Cytokine Signaling in the Bone Marrow Niche: Implications for Hematopoiesis in Health and Disease

edited by

Melinda Varney

submission deadline 28 Feb 2027 | Viewed by 275 | Submission Open

Keywords: bone marrow niche; bone marrow cytokine signaling; hematopoiesis; hematopoietic stem cells; microenvironmental regulation; inflammatory signaling; hematologic disease

(This special issue belongs to the Section Molecular Immunology)

Recent Advances in Cancer Immunotherapy Research

edited by

Luigi Pasini

submission deadline 28 Feb 2027 | Viewed by 274 | Submission Open

Keywords: immunotherapy; CAR T-Cell therapy; mRNA cancer vaccines; ICIs; TIL therapy; nanotechnology; antibody discovery; drug discovery; tumor microenvironment; microbiome modulation; metabolic reprogramming

(This special issue belongs to the Section Molecular Oncology)

Computational Strategies for Antiviral Drug Discovery: QSAR, In Silico Modeling and Data-Driven Approaches

edited by

Mohammed Salah

submission deadline 28 Feb 2027 | Viewed by 270 | Submission Open

Keywords: antiviral drug discovery; viral diseases; computational drug design; in silico modeling; quantitative structure–activity relationship (QSAR); molecular modeling; molecular dynamics simulations; virtual screening; machine learning in drug discovery; bioactive compounds; computer-aided drug design (CADD)

(This special issue belongs to the Section Molecular Informatics)

Innovative Advances in Cancer Therapy Through Nano-Based Systems

edited by

Lenuţa-Maria Şuta

and

Claudia Geanina Watz

submission deadline 28 Feb 2027 | Viewed by 270 | Submission Open

Keywords: nano-enabled delivery systems; innovative nanomaterials; smart nanocarriers; cancer nanotherapy; anti-tumorigenic activity

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Toxicity and Therapeutic Potential of Hymenoptera Venoms

edited by

Xesús Feás

submission deadline 28 Feb 2027 | Viewed by 269 | Submission Open

Keywords: hymenoptera venom; molecular toxicology; allergenicity; venom peptides; therapeutic applications; drug discovery; envenomation; bioactive compounds

(This special issue belongs to the Section Molecular Toxicology)

Cancer Genomics: Key Advances in the Precision Era

edited by

Maria Samara

submission deadline 28 Feb 2027 | Viewed by 266 | Submission Open

Keywords: cancer genomics; next-generation sequencing; artificial intelligence; computational biology; liquid biopsy; precision medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Emerging Advances in Fluorescent Biosensors

edited by

Xiaolong Liu

submission deadline 28 Feb 2027 | Viewed by 261 | Submission Open

Keywords: single molecule imaging; fluorescent probes; super-resolution imaging

(This special issue belongs to the Section Molecular Biophysics)

Pharmacological Mechanisms of Natural Products: Biological Targets and Clinical Perspectives

edited by Damião Pergentino De Sousa

submission deadline 28 Feb 2027 | Viewed by 261 | Submission Open

Keywords: central nervous system; inflammation; cancer; infection; metabolism; essential oils; medicinal plants; alkaloids; flavonoids; natural products

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Research on Oral Cancer

edited by Junichi Tanuma

submission deadline 28 Feb 2027 | Viewed by 260 | Submission Open

Keywords: oral squamous cell carcinoma; tumor microenvironment; immune regulation; molecular signaling; metabolic reprogramming; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Bringing New Molecular Insights into Neurodegenerative Diseases

edited by

Daniela Vecchio

submission deadline 28 Feb 2027 | Viewed by 259 | Submission Open

Keywords: neurodegeneration; pathogenic mechanisms; biomarkers; neuroimaging; artificial intelligence; protein aggregation; neuroinflammation; genetics and epigenetics; multi-omics; therapeutic targets

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Regulation of Cancer Stem Cells: Signaling Networks, Metabolism, and Therapeutic Targeting

edited by Shanchun Guo

submission deadline 28 Feb 2027 | Viewed by 259 | Submission Open

Keywords: glioma; cancer stem cell; drug design; small molecular; diagnosis; prognosis; pathology

(This special issue belongs to the Section Molecular Oncology)

Molecular Nutrition and Functional Foods: Mechanisms of Metabolic Health Regulation

edited by

Eugene Chang

submission deadline 28 Feb 2027 | Viewed by 257 | Submission Open

Keywords: nutrients; bioactive food components; functional food; signaling pathways; metabolism; metabolic regulation; nutrigenomics; gut microbiota; inflammation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Advances in Biomarkers of Central Nervous System Diseases and Disorders: 2nd Edition

edited by

David Gurwitz

and