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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Research in Orofacial Pain and Headache
edited by Adriana Elena Bulboaca
submission deadline 30 Apr 2026 | Viewed by 12 | Submission Open
Keywords: neuropathic pain; trigeminal neuralgia; temporomandibular joint disorders; headache; migraine; neuroplasticity
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Application of Natural Products in Biomedicine and Pharmacotherapy: 3rd Edition
edited by
submission deadline 30 Apr 2026 | Viewed by 6 | Submission Open
Keywords: natural products; biomedicine; genotoxicity; epigenetics; aging
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Advances on Gut Microbiota in Human Health
edited by
submission deadline 30 Apr 2026 | Viewed by 5 | Submission Open
Keywords: gut microbiota; dysbiosis; metabolomics; host– microbe interaction; molecular pathways; inflammation; personalized medicine
(This special issue belongs to the Section Molecular Microbiology)
Neural Circuit Mechanisms of Brain Disorders
edited by
submission deadline 30 Apr 2026 | Viewed by 2 | Submission Open
Keywords: dynamic wiring; brain network; brain connectivity; neuropathology; neuromodulation; neuroplasticity; circuit mapping
(This special issue belongs to the Section Molecular Neurobiology)
Advances on Viral Immunology and Pathogenesis of Viral Infections
edited by Yeong-Bin Baek
submission deadline 30 Apr 2026 | Viewed by 2 | Submission Open
Keywords: viral immunology; viral pathogenesis; innate sensing and interferon; cytokine networks and inflammasomes; adaptive immunity (T- and B-cell quality); immunometabolism and lipid signaling; host-directed antiviral strategies; transcriptomics and spatial omics; mechanism of action and target engagement; complex bioactive modulators
(This special issue belongs to the Section Molecular Microbiology)
Emerging Biological Markers and Molecular Targets in Bladder Cancer
edited by Stanislav Žiaran
submission deadline 30 Apr 2026 | Viewed by 2 | Submission Open
Keywords: bladder cancer; biomarkers; urothelial carcinoma; molecular pathways; liquid biopsy; extracellular matrix; omics profiling; precision medicine; tissue engineering; translational urology
(This special issue belongs to the Section Molecular Oncology)
Artificial Intelligence, Machine Learning, and Bioinformatics in Molecular Mechanisms of Human Health and Disease
edited by
submission deadline 30 Apr 2026 | Viewed by 1 | Submission Open
Keywords: artificial intelligence; machine learning; bioinformatics; molecular mechanisms; human health; human disease; multi-omics data; molecular pathways; personalized medicine; disease biomarkers
(This special issue belongs to the Section Molecular Informatics)
Advances in Lupus Erythematosus and Lupus Nephritis: Pathogenesis, Biomarkers and Treatments, 2nd Edition
edited by
submission deadline 30 Apr 2026 | Submission Open
Keywords: lupus erythematosus; lupus nephritis; SLE; LN; organ damage; pathogenesis; biomarkers; genomic; transcriptomic; metabolomic; treatments; therapeutic
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Insight in Reproductive Immunology
edited by Ruben Motrich
submission deadline 30 Apr 2026 | Submission Open
Keywords: reproductive immunology; immune tolerance; male reproductive tract; female reproductive tract; fertility disorders; inflammation; pregnancy complications; immunoregulation
(This special issue belongs to the Section Molecular Immunology)
Molecular Crosstalk Between Allergens, Microbes, and the Mucosal Immune System
edited by Stefanie Gilles
submission deadline 30 Apr 2026 | Submission Open
Keywords: allergens and innate immunity; mucosal immune signaling; epithelial barrier and inflammation; pathogen-allergen crosstalk; bioaerosol exposure; allergen recognition mechanisms; environmental immunology
(This special issue belongs to the Section Molecular Immunology)
Molecular and Physiological Effects of Exercise in Cachexia
edited by
submission deadline 30 Apr 2026 | Submission Open
Keywords: cachexia; skeletal muscle mass; skeletal muscle strength; exercise; muscle metabolism
(This special issue belongs to the Section Molecular Biology)
Dietary Interventions for Type 2 Diabetes: Current Evidence and Emerging Perspectives on Underlying Molecular Mechanisms
edited by Caterina Formichi
submission deadline 30 Apr 2026 | Submission Open
Keywords: type 2 diabetes; nutritional intervention; dietary strategies; nutrients; personalized nutrition; diet; metabolic health
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
From Molecular Insights to Novel Therapies: Neurological Diseases
edited by
submission deadline 20 May 2026 | 17 articles | Viewed by 60311 | Submission Open
Keywords: neurological diseases; neurodegenerative diseases; epilepsy; mental illness; transgenic animal models; molecular pathways; metabolism disabilities; mitochondrial dysfunction; oxidative stress; disturbances in epigenetic regulation
(This special issue belongs to the Section Molecular Neurobiology)
Targeted Therapy for Immune Diseases
edited by
submission deadline 20 May 2026 | 15 articles | Viewed by 45820 | Submission Open
Keywords: targeted therapy; immune diseases; biologics; immunotherapy; precision medicine; nanoparticles; biomarkers
(This special issue belongs to the Section Molecular Immunology)
Fascial Anatomy and Histology: Advances in Molecular Biology
edited by
submission deadline 20 May 2026 | 4 articles | Viewed by 26649 | Submission Open
Keywords: fascia; connective tissue; myofascial pain; collagen; hyaluronan
(This special issue belongs to the Section Molecular Biology)
Natural Compounds in Cancer Therapy and Prevention, 2nd Edition submission deadline 20 May 2026 | 6 articles | Viewed by 23881 | Submission Open
Keywords: cancer therapy cancer prevention; natural compounds; metastasis; immunomodulation; adjuvant therapy; preventive therapy; drug discovery; natural drugs
(This special issue belongs to the Section Molecular Pharmacology)
Advances in Anti-Inflammatory Activity of Natural Products of Plant Origin
edited by Radoslaw Zajdel
submission deadline 20 May 2026 | 2 articles | Viewed by 21647 | Submission Open
Keywords: anti-inflammatory; phytochemicals; natural products; medicinal plants; inflammation; cytokines; NF-κ B pathway; cyclooxygenase inhibitors; flavonoids; terpenoids; polyphenols; molecular mechanisms; drug discovery; ethnopharmacology; metabolomics
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Innovative Nanomaterials from Functional Molecules
edited by Xiaoming Zhang and
submission deadline 20 May 2026 | 5 articles | Viewed by 14777 | Submission Open
Keywords: functional materials; molecular design; molecular assembly; medicine; catalysis; battery; supercapacitor; sensing
(This special issue belongs to the Section Molecular Nanoscience)
Advances in Melanoma and Skin Cancers: 2nd Edition
edited by , and Maria Grazia Vitale
submission deadline 20 May 2026 | 6 articles | Viewed by 12512 | Submission Open
Keywords: melanoma; immunotherapy; biomarkers; translational research; drug repurposing; clinical outcome; prognostic markers; predictive markers; combination immunotherapy
(This special issue belongs to the Section Molecular Oncology)
The Roles of Photodynamic Therapy in Tumors and Cancers
edited by Jianyong Liu
submission deadline 20 May 2026 | 4 articles | Viewed by 10649 | Submission Open
Keywords: photodynamic therapy; PDT; photodetection; photosensitizers; photosensitizing agents; reactive oxygen species; molecular mechanisms; cell necrosis; apoptosis; singlet oxygen; synergetic therapy; combination therapy; delivery vehicles; immunophototherapy; nano-photosensitizer
(This special issue belongs to the Section Molecular Oncology)
Pathogenesis and Novel Therapeutic Approaches for Sarcomas
edited by Francisco Giner
submission deadline 20 May 2026 | 4 articles | Viewed by 10389 | Submission Open
Keywords: soft tissue tumors; bone tumors; molecular biology; target therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Liver Fibrosis: Molecular Pathogenesis, Diagnosis and Treatment
edited by Manuel Morales-Ruiz
submission deadline 20 May 2026 | 5 articles | Viewed by 10292 | Submission Open
Keywords: liver fibrosis; cirrhosis; hepatic stellate cells; collagen; fibrogenic pathways; diagnosis of fibrosis; therapeutic strategies for liver disease; extracellular matrix remodeling; cell-to-cell interactions; fibrosis complications
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Oxidative Stress and Antioxidants in Human Disease
edited by
submission deadline 20 May 2026 | 6 articles | Viewed by 10265 | Submission Open
Keywords: oxidative stress; free radicals; antioxidants; reactive oxygen species (ROS); polyphenols
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Mesenchymal Stem Cells in Organ Repair and Tissue Regeneration
edited by
submission deadline 20 May 2026 | 6 articles | Viewed by 10131 | Submission Open
Keywords: stem cells; differentiation; cell therapy; tissue regeneration; cell mechanisms; regenerative medicine; immunomodulation
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms and Therapies of Colorectal Cancer: 4th Edition submission deadline 20 May 2026 | 7 articles | Viewed by 9450 | Submission Open
Keywords: transforming growth factor beta (TGF-β ) signaling; genetic alterations; molecular targeted therapy precision medicine
(This special issue belongs to the Section Molecular Oncology)
New Cardiovascular Risk Factors: 2nd Edition
edited by
submission deadline 20 May 2026 | 4 articles | Viewed by 8875 | Submission Open
Keywords: atherosclerosis; cardiovascular risk; arterial stiffness; blood pressure; vitamin D; miRNA; inflammation
(This special issue belongs to the Section Molecular Biology)
Plant-Derived Bioactives: Antioxidant Mechanisms and Preventive Health Strategies
edited by
submission deadline 20 May 2026 | 3 articles | Viewed by 8456 | Submission Open
Keywords: antioxidant; plant-derived bioactive compounds; flavonoids; oxidative stress; mechanisms of action
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Cutting-Edge Methods for Exploiting Bioactive Compounds in Biomasses: From the Plant Matrix to Molecular Function
edited by Chiara Magni
submission deadline 20 May 2026 | 5 articles | Viewed by 8287 | Submission Open
Keywords: plant matrix; agri-food biomasses; biochemistry; bioactive compounds
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Impact of Mitochondria on Human Disease and Health
edited by
submission deadline 20 May 2026 | 5 articles | Viewed by 8067 | Submission Open
Keywords: mitochondrial dysfunction; mitochondrial bioenergetics; mitochondrial dynamics; mitophagy; oxidative stress; mitochondrial DNA (mtDNA) mutations; neurodegenerative diseases; cardiovascular diseases; metabolic disorders; aging and mitochondria; cancer
(This special issue belongs to the Section Biochemistry)
Fish Immunology, 5th Edition submission deadline 20 May 2026 | 4 articles | Viewed by 7871 | Submission Open
Keywords: fish immunology; innate immunity; acquired immunity; leucocytes; disease; immunostimulants; immunodepression; inflammation
(This special issue belongs to the Section Molecular Immunology)
Tumor Microenvironment and Cancer Progression: Molecular Insights for Targeted Therapy
edited by
submission deadline 20 May 2026 | 5 articles | Viewed by 7245 | Submission Open
Keywords: tumor microenvironment; immune response modulation; signaling pathways; extracellular matrix components; tumor evolution
(This special issue belongs to the Section Molecular Oncology)
Macrophages and Inflammation
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 7159 | Submission Open
Keywords: innate immunity; transcriptional programs; epigenetics; immunometabolism; receptors; scavenging; cytokines; ROS
(This special issue belongs to the Section Molecular Immunology)
Molecular Mechanisms and Treatment of Migraine
edited by Noboru Imai
submission deadline 20 May 2026 | 1 articles | Viewed by 7120 | Submission Open
Keywords: migraine; nitric oxide synthase (NOS); neuropeptides; calcitonin gene-related peptide (CGRP); pituitary adenylate cyclase activating polypeptide (PACAP); molecular pathways; therapeutic targets; neurovascular condition
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Effects of Stressors During Pregnancy and Breastfeeding on the Child: Molecular Perspectives submission deadline 20 May 2026 | 1 articles | Viewed by 7051 | Submission Open
Keywords: xenobiotics; drugs; gestation; breastfeeding; fetus; placenta; child’ s development; teratogenicity; central nervous system
(This special issue belongs to the Section Molecular Biology)
Antimicrobial and Antiviral Peptides: 2nd Edition
edited by
submission deadline 20 May 2026 | 4 articles | Viewed by 6896 | Submission Open
Keywords: antimicrobial peptides; antiviral peptides; peptide mining; molecular mechanism of biological activity; structure– activity relationship; molecular targets; in silico design; in vivo models; peptide delivery strategies; biomedical applications
(This special issue belongs to the Section Biochemistry)
Bioprinting: Progress and Challenges
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 6833 | Submission Open
Keywords: advances in 3D bioprinting technologies; biomaterials for bioprinting; bioprinting applications in tissue engineering and regenerative medicine; cellular and molecular interactions in bioprinted constructs; bio-printed organ and tissue models for disease research
(This special issue belongs to the Section Materials Science)
Bioactive Compound Delivery Systems and Microbiome Interactions submission deadline 20 May 2026 | 2 articles | Viewed by 6765 | Submission Open
Keywords: bioactive compounds; delivery systems; gut microbiome; personalized nutrition; bioavailability; encapsulation technologies; microbiome– bioactive interactions; targeted delivery; precision nutrition; synergistic interactions
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advances in G Protein-Coupled Receptor Signaling
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 6634 | Submission Open
Keywords: G protein-coupled receptors (GPCRs)G蛋白偶联受体; seven transmembrane domain (7TM) receptors七跨膜结构域受体; metabotropic receptors代谢型受体; membrane receptors膜受体; GPCRs signalingGPCR信号; GPCRs signaling pathwaysGPCR信号通路; anti-inflammatory effects抗炎作用; inflammatory diseases炎性疾病; metabolic diseases代谢疾病; metabolic effects代谢效应; anti-inflammatory treatment抗炎治疗
(This special issue belongs to the Section Molecular Immunology)
Molecular Ecology, Physiology and Biochemistry of Insects, 5th Edition
edited by
submission deadline 20 May 2026 | 3 articles | Viewed by 6614 | Submission Open
Keywords: insect development and reproduction; molecular endocrinology/neuropeptides; insect immunity; photoperiodism; cold hardiness; global climate change; insect aging; insect– plant interactions; molecular interactions of insects with microorganisms; chemical communication; biochemistry of insect venoms; insect genomics and proteomics; genetic engineering; molecular; volution/population genetics; insect biotechnology
(This special issue belongs to the Section Molecular Immunology)
New Advances in Opioid Research
edited by Matthew E. Layton
submission deadline 20 May 2026 | 5 articles | Viewed by 5784 | Submission Open
Keywords: methadone; buprenorphine; hyperbaric oxygen; complementary/alternative/integrative treatments; patient-centered outcomes
(This special issue belongs to the Section Molecular Pharmacology)
The Role of Natural Compounds in Cancer and Inflammation, 2nd Edition
edited by
submission deadline 20 May 2026 | 4 articles | Viewed by 5641 | Submission Open
Keywords: natural compounds; oxidative stress; anti-cancer; anti-inflammatory; natural product synthesis; biological activities
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms of Vascular Protection by Means of Nutraceuticals
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 5634 | Submission Open
Keywords: cardiovascular disease; drugs; nutrients
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Technical Developments and Recent Applications of Cellular Molecular Imaging
edited by Hanae Sato
submission deadline 20 May 2026 | 3 articles | Viewed by 5631 | Submission Open
Keywords: fluorescence imaging; optogenetics; single-molecule imaging; cellular dynamics; real-time imaging; structural and functional imaging; multimodal imaging
(This special issue belongs to the Section Molecular Biology)
Periodontal Disease: From Molecular Pathogenesis to Precision Diagnostics and Innovative Therapeutics
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 5557 | Submission Open
Keywords: periodontitis; gingivitis; oral microbiome; host– pathogen interactions; periodontal immunology; systemic inflammation; salivary diagnostics; periodontal regeneration; precision dentistry; oral-systemic connections; inflammatory biomarkers; antimicrobial peptides; peri-implantitis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exploring Cannabinoids: Molecular Mechanisms and Potential Therapeutic Applications
edited by
submission deadline 20 May 2026 | 4 articles | Viewed by 5249 | Submission Open
Keywords: cannabinoids; endocannabinoid system; δ 9-tetrahydrocannabinol (THC); cannabidiol (CBD); inflammation; chronic pain; neurodegenerative disorders; epilepsy; psychosis; cancer-related symptoms
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Emerging Biological and Molecular Targets in Schizophrenia
edited by Jacopo Sapienza
submission deadline 20 May 2026 | 4 articles | Viewed by 5198 | Submission Open
Keywords: schizophrenia; cognition; negative symptoms; synapses; kynurenine pathway; TAAR1; psychedelics; new treatments
(This special issue belongs to the Section Molecular Neurobiology)
Advanced Research in Antioxidant Activity
edited by Demetrios Kouretas and
submission deadline 20 May 2026 | 3 articles | Viewed by 5014 | Submission Open
Keywords: xenobiotics; oxidative stress; free radicals; reactive oxygen species; reactive nitrogen species; antioxidants; glutathione; toxicology; redox metabolism; redox imbalance
(This special issue belongs to the Section Biochemistry)
Extraction, Identification and Quantification of Bioactive Molecules
edited by and Rosario Mare
submission deadline 20 May 2026 | 2 articles | Viewed by 4981 | Submission Open
Keywords: extracts; botanicals; nutraceuticals; bioactive molecules; spectrometry; spectrophotometer; chromatography; western blotting; molecular mechanisms
(This special issue belongs to the Section Molecular Biology)
Molecular Applications of Technologies and Techniques for the Extraction of Simple Molecules and Compounds
edited by
submission deadline 20 May 2026 | 5 articles | Viewed by 4975 | Submission Open
Keywords: sample preparation; natural product extraction; purification; pollutant extraction; nutraceutical extraction; extraction of environmental indicators; magnetic extraction; green analytical chemistry; liquid– liquid (micro)extraction; cloud point (micro)extraction; solid phase (micro)extraction; pressurized liquid extraction; ultrasound-assisted extraction; microwave-assisted extraction; deep eutectic solvents; supercritical fluid extraction; molecularly imprinted polymers; QuEChERS (quick; easy; cheap; effective; rugged and safe)
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Host Responses to Virus Infection
edited by Hideki Hayashi and Yoshinao Kubo
submission deadline 20 May 2026 | 3 articles | Viewed by 4966 | Submission Open
Keywords: viral infection; host reactions; interferon alpha and beta; interferon gamma; cytokines; vaccine; cytokine storm
(This special issue belongs to the Section Molecular Microbiology)
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