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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Research in Nutritional Physiology and Gut Microbiome

edited by

Haiqiang Yao

submission deadline 30 Apr 2027 | 1 articles | Viewed by 606 | Submission Open

Keywords: nutritional physiology; gut microbiome; microbial metabolites; nutrient sensing; metabolic homeostasis; gut–brain axis; prebiotics; probiotics; molecular nutrition

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Neurotransmitter Dysregulation in Brain Disease: Focus on Epilepsy and Its Comorbidities

edited by

Giuseppe Di Giovanni

submission deadline 30 Apr 2027 | Viewed by 456 | Submission Open

Keywords: neurotransmitter dysregulation; epilepsy; addiction; serotonin; GABA; molecular neuroscience; neuropharmacology; brain networks

(This special issue belongs to the Section Molecular Neurobiology)

Epigenetic Regulation in Cell Development, Differentiation and Cell Fate

edited by Gang Ren

submission deadline 30 Apr 2027 | Viewed by 435 | Submission Open

Keywords: 3D genome; myogenesis; transgenerational inheritance; enhancer–promoter interaction; histone modification; epigenetic variation; complex traits

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Therapeutic Antibody Engineering

edited by

Chatchai Tayapiwatana

submission deadline 30 Apr 2027 | Viewed by 403 | Submission Open

Keywords: therapeutic antibodies; bispecific antibodies; antibody-drug conjugates (ADCs); nanobodies; AI-driven drug design; Fc engineering; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Cardioprotective Mechanisms in Myocardial Ischemia

edited by Virginia Pérez and Verónica D’annunzio

submission deadline 30 Apr 2027 | Viewed by 350 | Submission Open

Keywords: myocardial ischemia; ischemia–reperfusion injury; cardioprotection; molecular signaling; oxidative stress; inflammation; cardiac remodeling; therapeutic targets; translational cardiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Inherited Endocrine Tumors: Genetics, Genomics, and Molecular Pathogenesis

edited by Vito Guarnieri,

Alberto Falchetti

and Antonio Stefano Salcuni

submission deadline 30 Apr 2027 | Viewed by 348 | Submission Open

Keywords: parathyroid; adrenal; pancreas; thyroid; pituitary

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Mechanisms in Cardiovascular and Metabolic Diseases: Effective and Potential Treatments

edited by

Alex Cleber Improta-Caria

submission deadline 30 Apr 2027 | Viewed by 328 | Submission Open

Keywords: molecular mechanisms; cardiovascular diseases; metabolic diseases; microRNAs; circRNAs; long non-coding RNAs; epigenetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

DNA Damage and Repair Mechanisms in Cancer Development

edited by

Mengfan Tang

submission deadline 30 Apr 2027 | Viewed by 320 | Submission Open

Keywords: DNA damage response and repair; DNA replication; genome instability; drug resistance; targeted therapy; cellular senescence; innate immunity; nucleic acid homeostasis

(This special issue belongs to the Section Molecular Oncology)

Advances in Plant Transporters and Tolerance Proteins

edited by Kun Qiao

submission deadline 30 Apr 2027 | Viewed by 281 | Submission Open

Keywords: heavy metal; transporter; antioxidant; ornamental plants and horticulture; ion transport; phytoremediation; biofortification

(This special issue belongs to the Section Molecular Plant Sciences)

Mapping Lipid Metabolism in Cancer: Cellular, Metabolic, and Molecular Approaches

edited by

Iorio Egidio

submission deadline 30 Apr 2027 | Viewed by 280 | Submission Open

Keywords: lipid metabolism; cancer; metabolomics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

RNA Structure and Regulation in Biological Processes

edited by Changrui Lu

submission deadline 30 Apr 2027 | Viewed by 251 | Submission Open

Keywords: RNA structure; RNA three-dimensional conformation; RNA dynamics; RNA chemical modifications; structural biology; RNA–protein interactions; RNA structures in plant disease resistance; viral RNA structure and function; computational structure prediction; host–pathogen interactions

(This special issue belongs to the Section Biochemistry)

Forward in Vasculitis: Genetics and Beyond, 2nd Edition

edited by

Marija Jelusic

submission deadline 30 Apr 2027 | Viewed by 238 | Submission Open

Keywords: systemic vasculitides; ethiopathogenesis; risk factors; genetics; genomics; proteomics; transcriptomics; epigenetics; molecular pathways; novel therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Design, Synthesis and Evaluation of Anticancer Agents

edited by

Gourav Kumar

submission deadline 30 Apr 2027 | Viewed by 234 | Submission Open

Keywords: anticancer drug design; structure–activity relationship (SAR); molecular targets in cancer; synthetic antitumor agents; in vitro and ex vivo cancer models; molecular pharmacology

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Insights into Plant–Soil–Microbe Interactions Under Abiotic Stress

edited by

Youcai Xiong

and

Muhammad Abrar

submission deadline 30 Apr 2027 | Viewed by 228 | Submission Open

Keywords: abiotic stress; microbial metabolites; molecular signaling; plant–microbe interactions; plant stress tolerance; rhizosphere microbiome; stress-responsive genes

(This special issue belongs to the Section Molecular Plant Sciences)

Biochemical Mechanisms of the Gut–Brain Axis: Microbial Metabolites, Barrier Integrity, and Neuroimmune Signaling

edited by

Sidharth Prasad Mishra

submission deadline 30 Apr 2027 | Viewed by 141 | Submission Open

Keywords: gut–brain axis; gut microbiota; microbial metabolites; intestinal barrier integrity; neuroimmune signaling; host-microbiome interactions; microbiome-brain communication; neuroinflammation; multi-omics; microbiome-based therapeutics

(This special issue belongs to the Section Molecular Biology)

Targeting Membrane Proteins: Structure, Function, and Dynamic Relationships

edited by Ki-Young Lee

submission deadline 30 Apr 2027 | Viewed by 120 | Submission Open

Keywords: membrane proteins; conformational dynamics; allosteric regulation; signal transduction; drug discovery; cryo-electron microscopy; nuclear magnetic resonance spectroscopy; artificial intelligence; membrane mimetics

(This special issue belongs to the Section Molecular Biology)

Advanced Research on Functional Genomics and Genome Editing in Plants

edited by

Rushil Ramesh Mandlik

submission deadline 30 Apr 2027 | Viewed by 43 | Submission Open

Keywords: CRISPR/Cas; genome editing; functional genomics; plant biotechnology; gene regulation; base editing; prime editing; gene overexpression; multi-omics; crop improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Gut Microbiota and Microbe-Host Interactions in Cancer

edited by

Jessie Qiaoyi Liang

submission deadline 30 Apr 2027 | Viewed by 21 | Submission Open

Keywords: microbe–host interaction; metabolite; virulence factor; cancer signaling; gene regulation

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research on Dental Restorative Materials

edited by Yuanyuan Han

submission deadline 30 Apr 2027 | Viewed by 19 | Submission Open

Keywords: dental restorative materials; dental biomaterials; bioactive materials; molecular mechanisms; biocompatibility; remineralization; tissue regeneration; regenerative dentistry

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Regulation of Intestinal Barrier Function

edited by

Vanessa D’Antongiovanni

submission deadline 30 Apr 2027 | Viewed by 16 | Submission Open

Keywords: intestinal epithelial barrier; gut inflammation; immune cells; enteric glia; enteric nervous system; gut–brain axis; microbiota; neuroinflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Advances in Neuroinflammation Research

edited by

Tauheed Ishrat

submission deadline 30 Apr 2027 | Viewed by 10 | Submission Open

Keywords: neuroinflammation; microglia; astrocytes; NLRP3 inflammasome; neurovascular unit; blood–brain barrier; traumatic brain injury; ischemic stroke; Alzheimer’s disease; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Latest Reviews in Molecular Plant Science 2027

edited by

Maoteng Li

and

Jinsong Bao

submission deadline 30 Apr 2027 | Viewed by 9 | Submission Open

Keywords: gene cloning and gene functional analysis; gene editing; multi-omics integration analysis; plant development; metabolic pathway; biotic and abiotic stresses

(This special issue belongs to the Section Molecular Plant Sciences)

Multi-Omics-Driven Precision Oncology: Bridging Bioinformatics, Translational Research and Clinical Implementation

edited by Yang Shi and

Yin Wan

submission deadline 30 Apr 2027 | Viewed by 5 | Submission Open

Keywords: multi-omics; cancer bioinformatics; computational oncology; precision oncology; translational oncology; cancer genomics; transcriptomics; proteomics; metabolomics; single-cell omics; spatial omics; tumor microenvironment; molecular biomarkers; artificial intelligence; clinical implementation

(This special issue belongs to the Section Molecular Oncology)

Molecular Insights into Electrocatalytic Water Splitting and Sustainable Hydrogen Production

edited by

Md Ahasan Habib

submission deadline 30 Apr 2027 | Viewed by 3 | Submission Open

Keywords: electrocatalytic water splitting; sustainable hydrogen production; molecular insights; reaction mechanisms; hydrogen evolution reaction (HER); oxygen evolution reaction (OER); active site engineering; structure–activity relationships; advanced functional materials; density functional theory (DFT); proton exchange membrane (PEM) electrolyzer; anion exchange membrane (AEM) water electrolysis; degradation mechanisms; green hydrogen production; electrocatalyst durability

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Mechanisms Governing Microbial Bioremediation Performance in Environmental Matrices

edited by

Armstrong Omoregie

submission deadline 30 Apr 2027 | Viewed by 1 | Submission Open

Keywords: microbial bioremediation performance; catabolic gene expression; functional metagenomics and metatranscriptomics; degradative enzyme kinetics; transformation products and degradation pathways; stable isotope probing; contaminant speciation and immobilisation stability; microbially induced biomineralisation; bioaugmentation and inoculum persistence; environmental matrices

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms Regulating Stress Tolerance in Ornamental Plants

edited by

Haizhen Zhang

submission deadline 20 May 2027 | Viewed by 203 | Submission Open

Keywords: ornamental plants; biotic stresses; abiotic stresses; signal transduction pathways; transcription factors; functional proteins; transcription; translation; post-translational modification

(This special issue belongs to the Section Molecular Plant Sciences)

Melanoma: Molecular Mechanism and Therapy, 2nd Edition

edited by

Balázs Margit

submission deadline 30 May 2027 | 3 articles | Viewed by 4185 | Submission Open

Keywords: melanoma progression; melanoma metastasis; molecular background; targeted therapies; immunotherapy; acquired drug resistance; prognostic and predictive markers; therapeutic targets

(This special issue belongs to the Section Molecular Oncology)

Molecular Evolution of the Vertebrate Immune System

edited by

Pierre Pontarotti

submission deadline 30 May 2027 | 1 articles | Viewed by 1535 | Submission Open

Keywords: immune system; molecular evolution; V (D) J recombination; RAG transposon; comparative genomics

(This special issue belongs to the Section Molecular Biology)

Agronomic Regulation of Crop Environmental Adaptation and Grain Safety: Physiological and Molecular Mechanisms

edited by

Ligeng Jiang

and

Sun Yujun

submission deadline 30 May 2027 | Viewed by 41 | Submission Open

Keywords: agronomic management; environmental adaptation; molecular regulation; physiological and biochemical mechanisms; crop quality formation; plant-soil-microbe interactions; heavy metal detoxification; nitrogen-use efficiency; photosynthetic efficiency

(This special issue belongs to the Section Molecular Plant Sciences)

State-of-the-Art Molecular Plant Sciences in China

edited by Xiaoling Sun

submission deadline 30 May 2027 | Viewed by 22 | Submission Open

Keywords: molecular plant science; plant molecular biology; plant physiology and development; plant omics and bioinformatics; plant biotechnology

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Aspects of Diabetes and Its Complications

edited by

Giuseppe Murdolo

submission deadline 31 May 2027 | 3 articles | Viewed by 2887 | Submission Open

Keywords: obesity; insulin resistance; type 2 diabetes; atherosclerosis; endothelial dysfunction; cardiovascular disease; peripheral artery disease; diabetic feet; diabetic micoangiopathy; diabetic neuropathy; regenerative medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Biology on Environmental Microorganisms

edited by

Mariusz Cycoń

submission deadline 31 May 2027 | 3 articles | Viewed by 2034 | Submission Open

Keywords: environmental microbiology; metagenomics; microbial interactions; phage–host dynamics; horizontal gene transfer; biogeochemical cycles; antimicrobial resistance; single-cell methods; microbiome engineering; environmental biotechnology

(This special issue belongs to the Section Molecular Microbiology)

Neurobiology Linking Alcohol Addiction to Psychiatry Symptoms

edited by

Jorge Manzanares

and

Francisco Navarrete Rueda

submission deadline 31 May 2027 | 1 articles | Viewed by 2033 | Submission Open

Keywords: alcohol use disorder (AUD); psychiatry; neurobiology; biomarkers; translational

(This special issue belongs to the Section Molecular Neurobiology)

New Insights into Environmental Stresses and Plants: Second Edition

edited by

Zhou Li

submission deadline 31 May 2027 | 1 articles | Viewed by 1580 | Submission Open

Keywords: abiotic stress; biotic stress; adaptation; gene function; omics; metabolic regulation; stress signal; molecular mechanism

(This special issue belongs to the Section Molecular Plant Sciences)

Bioactive Compounds and Molecular Mechanisms in Health and Disease

edited by

Lucas Fornari Laurindo

and

Maria Angélica Miglino

submission deadline 31 May 2027 | Viewed by 885 | Submission Open

Keywords: bioactive compounds; molecular mechanisms; metabolic regulation; inflammation; oxidative stress; signaling pathways; chronic diseases; translational research; systems biology; disease prevention and therapy

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Determinants of Cardiovascular Diseases

edited by

Susan Darroudi

submission deadline 31 May 2027 | 1 articles | Viewed by 727 | Submission Open

Keywords: atherosclerosis; hypertension; diabetes; dyslipidemia; endothelial dysfunction; vascular remodeling; inflammation and oxidative stress; mitochondrial dysfunction; molecular diagnostics; heart function

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

MiRNA Regulation in the Early PME/TME: The Role of Non-Cancer Cells and the ECM in Solid Tumours

edited by

Kurt Sartorius

submission deadline 31 May 2027 | 1 articles | Viewed by 549 | Submission Open

Keywords: microRNAs; early tumor microenvironment (TME); stromal/ECM interaction; vascularization; ECM remodelling; signalling pathways

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of GPCR Signaling

edited by

Kyeong-Man Kim

submission deadline 31 May 2027 | Viewed by 438 | Submission Open

Keywords: biased signaling; allosteric modulation; receptor conformations; spatiotemporal signaling; allosteric modulation; receptor trafficking; signaling networks; structure-based drug design

(This special issue belongs to the Section Biochemistry)

Advanced Drug Delivery Systems: From Nanocarrier Design to Translation

edited by

Krishna Jadhav

and

Satish Rojekar

submission deadline 31 May 2027 | Viewed by 137 | Submission Open

Keywords: nanocarriers; stimuli-responsive; targeted delivery; biocompatibility; scale-up; nanomedicine

(This special issue belongs to the Section Materials Science)

Molecular Mechanisms Linking Environmental Pollutant Exposure to Human Health and Development

edited by

Agnieszka Ścibior

and

Juan Llopis

submission deadline 31 May 2027 | Viewed by 96 | Submission Open

Keywords: environmental pollutants; molecular toxicology; developmental toxicology; particulate matter; metals and metalloids; pesticides; persistent organic pollutants; PFAS; environmental pharmaceuticals; microplastics; nanoplastics; mixture toxicity; adverse outcome pathways; human biomonitoring; toxicokinetics; oxidative stress; genotoxicity; epigenetics; endocrine disruption; neurodevelopment; human health risk assessment

(This special issue belongs to the Section Molecular Toxicology)

Drought‑Stress‑Induced Physiological and Molecular Changes in Plants

edited by

Yandong Yao

submission deadline 31 May 2027 | Viewed by 23 | Submission Open

Keywords: drought stress; abiotic stress; physiological response; reactive oxygen species; osmotic adjustment; molecular regulation; transcription factors; signal transduction; plant adaptation; omics; crop resilience

(This special issue belongs to the Section Molecular Plant Sciences)

Functional Polymeric Biomaterials: From Molecular Engineering to Biomedical Applications

edited by

Joanna Rydz

Marta Musioł

, Khadar Duale and

Barbara Zawidlak-Węgrzyńska

submission deadline 1 Jun 2027 | Viewed by 74 | Submission Open

Keywords: polymeric biomaterials; biodegradable polymers; molecular design; AI-driven materials design; structure–property relationships; biomolecule–material interactions; biocompatibility; drug delivery systems; tissue engineering; regenerative medicine

(This special issue belongs to the Section Materials Science)

The Chitosan Biomaterials: Advances and Challenges, 3rd Edition

edited by

Lacramioara Popa

Mihaela Violeta Ghica

and Cristina Elena Dinu-Pirvu

submission deadline 20 Jun 2027 | 1 articles | Viewed by 1620 | Submission Open

Keywords: chitosan; chitosan biomaterials; chitosan derivatives; drug delivery; wound healing; tissue regeneration; dentistry; smart biomaterials

(This special issue belongs to the Section Materials Science)

Molecular Progression of Genome-Related Diseases: 2nd Edition

edited by

Salvatore Saccone

submission deadline 25 Jun 2027 | 6 articles | Viewed by 23084 | Submission Open

Keywords: next-generation sequencing; genetic diseases; multifactorial diseases; diagnostic tolls; human health

(This special issue belongs to the Section Molecular Genetics and Genomics)

Innovative Strategies in Cancer Therapy

edited by

Paolo Coghi

and

Carmine Coluccini

submission deadline 30 Jun 2027 | 3 articles | Viewed by 8280 | Submission Open

Keywords: tumor microenvironment; small molecules; IDO1 inhibition; checkpoint inhibitor therapy; adoptive T cell therapy; metabolic reprogram; resistance mechanisms; immune modulation; immune reconstitution; combination therapy; immunosuppression

(This special issue belongs to the Section Molecular Oncology)

Targeting Oxidative Stress: New Insights into Disease Pathogenesis, Emerging Preventive Strategies and Novel Therapeutic Approaches

edited by Fabio Vivarelli and

Donatella Canistro

submission deadline 30 Jun 2027 | 3 articles | Viewed by 3440 | Submission Open

Keywords: metabolism; inflammation; oxidative stress; diabetes; natural oxidative stress modulators; novel preventive/therapeutic strategies; ageing; cardiovascular diseases; regenerative medicine; neurodegeneration; environmental exposure; cancer

(This special issue belongs to the Section Molecular Biology)

Effects of Bioactive Compounds in Cardiovascular and Neurological Diseases

edited by

Paul-Mihai Boarescu

submission deadline 30 Jun 2027 | 1 articles | Viewed by 2837 | Submission Open

Keywords: inflammation; oxidative stress; bioactive compounds; cardiovascular diseases; neurological diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Sex and Gender Medicine: New Horizons in Human Health and Disease

edited by

Alessandra Carè

, Eliana Ferroni and

Elena Ortona

submission deadline 30 Jun 2027 | 1 articles | Viewed by 574 | Submission Open

Keywords: sex differences; gender medicine; personalized medicine; health inequities; intersectionality; precision health

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

From Molecular Understanding to Ecological Significance: Understanding Marine Reproductive Biology

edited by

Zohaib Noor

submission deadline 30 Jun 2027 | Viewed by 457 | Submission Open

Keywords: reproductive biology; gametogenesis; bivalves reproduction; biodiversity; endocrine regulation; gametogenesis; molecular signaling; genomics; fertilization; population dynamics; ecological resilience

(This special issue belongs to the Section Molecular Biology)

Molecular Pharmacology and Analytical Characterisation of Bioactive Natural Products

edited by

Ivan Lozada Lawag

and

Vanessa Joy Timoteo

submission deadline 30 Jun 2027 | Viewed by 61 | Submission Open

Keywords: natural products; molecular pharmacology; bioactive compounds; herbal medicine; HPTLC; LC–MS/MS; metabolomics; chemometrics; natural product standardization; antioxidant activity; pharmacogenomics; transcriptomics; nutrigenomics; multi-omics; gene expression; genomic biomarkers

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Displaying special issue 3001-3050 on page 61 of 62.

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