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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Endothelial Dysfunction and Its Related Cardiometabolic Disorders: From Mechanisms to Targeted Therapies

edited by

Nacci Carmela

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2658 | Submission Open

Keywords: endothelial dysfunction; endothelial activation; endothelial nitric oxide synthase; cardiometabolic disease; vascular inflammation; chemokines; adipocytokines; atherosclerosis; diabetes; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Erythrocyte Cell Death: Molecular Insights

edited by

Anton Tkachenko

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2465 | Submission Open

Keywords: cell death signaling; eryptosis; erythrocyte senescence; erythrocytes; necroptosis; regulated cell death

(This special issue belongs to the Section Molecular Biology)

Sperm Oxidative Stress and Male Infertility

edited by

Kamil Gill

submission deadline 20 Feb 2026 | 3 articles | Viewed by 2336 | Submission Open

Keywords: oxidative stress; antioxidant system; free radical scavengers; sperm DNA oxidation; sperm DNA fragmentatio; antioxidant therapy; male infertility; male oxidative stress infertility

(This special issue belongs to the Section Molecular Biology)

New Insights in Antibody Therapy

edited by

Loredana Frasca

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2308 | Submission Open

Keywords: biological therapy; antibody therapy; non-communicable diseases; infectious diseases; chronic disease

(This special issue belongs to the Section Molecular Immunology)

Recent Research of Nanomaterials in Molecular Science: 2nd Edition

edited by

Giovanna Iezzi

submission deadline 20 Feb 2026 | 3 articles | Viewed by 2024 | Submission Open

Keywords: nanomaterials; medical research; synthesis and characterization; molecular formula; molecular dynamics; molecular imaging; cell signaling; cellular metabolism; tissue regeneration; biocompatibility; molecular biology; nanomedicine; functional nanomaterials; drug and gene delivery; tissue engineering; cancer therapy

(This special issue belongs to the Section Molecular Nanoscience)

Progress in the Use of Graphene and Graphene-Like Materials in Various Applications

edited by Piotr Kamedulski

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2000 | Submission Open

Keywords: graphene; porous carbons; carbon-based materials; 3D graphene; graphene exfoliation; nanotubes; nanomaterials; N-rich nano-porous carbon matrixes; N-rich activated carbons; carbon molecular sieves; hybrid materials; medical applications

(This special issue belongs to the Section Materials Science)

Gut Microbiota and Nutrition in Human Health (2nd Edition)

edited by

Sunmin Park

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1962 | Submission Open

Keywords: microbiome; gut; brain; obesity; diabetes; inflammation; liver; nutrition; probiotic; prebiotic

(This special issue belongs to the Section Molecular Microbiology)

Anti-Cancer, Anti-Inflammatory, and Antioxidation Active Substances: 3rd Edition

edited by

Ming-Ju Hsieh

submission deadline 20 Feb 2026 | 3 articles | Viewed by 1892 | Submission Open

Keywords: anti-inflammatory; anti-cancer; antioxidants; antiproliferative; antiviral; antibacterial; antibodies; molecular mechanism; chemoresistance; molecular biology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Immune Mechanisms and Biomarkers in Systemic Lupus Erythematosus—Second Edition

edited by

Ioannis Parodis

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1862 | Submission Open

Keywords: systemic lupus erythematosus; lupus nephritis; neuropsychiatric lupus; autoimmunity; biomarkers; B lymphocyte; interferons

(This special issue belongs to the Section Molecular Immunology)

Molecular Biology of Lung Cancer: From Intrinsic to Acquired Resistance Mechanisms

edited by

Federico Pio Fabrizio

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1827 | Submission Open

Keywords: lung cancer; NSCLC; cancer therapy; resistance; DNA methylation

(This special issue belongs to the Section Molecular Oncology)

Circulating Non-Coding RNAs as Diagnostic and Prognostic Markers of Human Diseases: 3rd Edition

edited by

Kyriacos N. Felekkis

and

Christos Papaneophytou

submission deadline 20 Feb 2026 | 3 articles | Viewed by 1801 | Submission Open

Keywords: miRNA; gene expression regulation; diagnosis; prognosis; therapy; biomarkers

(This special issue belongs to the Section Biochemistry)

Molecular Diagnosis in Cardiovascular Diseases

edited by Calogera Pisano,

Carmela Rita Balistreri

and Giuseppe Raffa

submission deadline 20 Feb 2026 | 2 articles | Viewed by 1783 | Submission Open

Keywords: cardiac diseases; molecular diagnosis; aortopathy; aneurysm; dissection; heart failure

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Micro(nano) Plastics and Estrogens as Endocrine Disruptors Meet the Female Reproductive System, Breast and Colon: What Is Going On?

edited by

Anna Maria Giuseppina Poma

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1772 | Submission Open

Keywords: micro(nano) plastics; estrogens; endocrine disruptors; female reproductive system; breast; colon

(This special issue belongs to the Section Molecular Biology)

New Insights into the Antibacterial Effect of Nano- and Micro-Materials

edited by

Krasimir Vasilev

and

Vi Khanh Truong

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1746 | Submission Open

Keywords: antibacterial coatings; biomaterials; medical devices; antimicrobial resistance; nanomedicine

(This special issue belongs to the Section Materials Science)

Functional Genomics of Insects: Unraveling Genetic Mechanisms and Applications

edited by

Bin Li

submission deadline 20 Feb 2026 | 3 articles | Viewed by 1743 | Submission Open

Keywords: genomics; comparative genomics; gene regulation networks; developmental biology; metamorphosis; vector biology; insecticide resistance mechanisms; insect– plant interactions; environmental adaptation

(This special issue belongs to the Section Molecular Genetics and Genomics)

Hearing Loss: Recent Progress in Molecular Genomics

edited by

Chen-Chi Wu

submission deadline 20 Feb 2026 | 2 articles | Viewed by 1597 | Submission Open

Keywords: hearing loss; high-throughput sequencing; prognostic analyses; translational medicine; gene therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Osteoimmunology: Interactions of the Bone and Immune System

edited by

Galliera Emanuela Rita

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1593 | Submission Open

Keywords: osteoimmunology markers; bone infection; inflammation and bone; immune response and bone; diagnostic and prognostic markers; bone remodeling; osteoclasts; immune-mediated bone diseases; bone– immune interface

(This special issue belongs to the Section Molecular Immunology)

The Molecular Network, Key Biomarkers, and Therapeutic Targets in Colorectal Cancer

edited by

Katharina M. Robertson

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1484 | Submission Open

Keywords: inflammation; metabolism; tumor-associated macrophages; tumor microenvironment; early-onset colorectal cancer; colorectal neoplasms; obesity; immunotherapy; epigenetics; cytokines; microbiome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Intestinal 3D Culture, Organoids and Gut-on-Chip in Intestinal Disorders

edited by

Vanessa D’Antongiovanni

and

Carolina Pellegrini

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1448 | Submission Open

Keywords: 3D cultures; gut-on-chip; intestinal organoids; spheroids; organotypic cultures; morphological studies; pharmacological studies; intestinal cancer; inflammatory bowel disease; intestinal functional disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Neutrophil Extracellular Traps (Nets) in Human Diseases

edited by Eisuke F. Sato

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1238 | Submission Open

Keywords: neutrophil extracellular traps (NETs); neutrophils; inflammation; autoimmune diseases; cardiovascular diseases; tumor metastasis; thrombosis; molecular mechanisms; disease progression; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Developments in Glioblastoma Research and Therapy: 2nd Edition

edited by

Aleksandra Majchrzak-Celińska

submission deadline 20 Feb 2026 | 2 articles | Viewed by 1227 | Submission Open

Keywords: diagnostic; prognostic and predictive biomarkers of glioblastoma; ways to target glioma stem cells; targeting glioblastoma-related signaling pathways; epigenetics of glioblastoma; treatment resistance mechanisms; novel treatment options for glioblastoma; combinatorial therapies; immunotherapy; nanotherapy; the application of CRISPR/Cas9 in glioma research; molecular testing of long-term glioblastoma survivors

(This special issue belongs to the Section Molecular Neurobiology)

Biosynthesis of Phytochemicals and Their Applications in Novel Drug Lead Development

edited by

Piotr Szymczyk

submission deadline 20 Feb 2026 | 2 articles | Viewed by 1059 | Submission Open

Keywords: biosynthesis of phytochemicals in plants; phytochemical isolation; phytochemical structure; animal and human protein targets of phytochemicals; chemical derivatives of phytochemicals

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Research in Asthma and Allergy

edited by

Sylwia Smolińska

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1056 | Submission Open

Keywords: asthma; allergy; molecular mechanisms; exposome; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Therapeutic Targets in Cardiometabolic Disorders

edited by Massimiliano M. Corsi Romanelli and

Pietro Formisano

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1055 | Submission Open

Keywords: atherosclerosis; angiotensin; endothelial cell; inflammation; biomarkers; gLP-1; sT-2

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Editorial Board Member's Collection Series: The Memory of the Immune Cells

edited by

Malgorzata Kloc

and

Jacek Z. Kubiak

submission deadline 20 Feb 2026 | 1 articles | Viewed by 946 | Submission Open

Keywords: immunological memory; innate immune memory; dendritic cells; natural killer cells; macrophage memory

(This special issue belongs to the Section Molecular Immunology)

Environmental Heavy Metals with Their Benefits and Risks for Human Health

edited by

Rolf Teschke

submission deadline 20 Feb 2026 | 1 articles | Viewed by 886 | Submission Open

Keywords: heavy metals; metal compound; iron; copper; cadmium; arsenic; oxidative stress; cell death; toxicology; Wilson disease; hemochromatosis

(This special issue belongs to the Section Molecular Toxicology)

Exploring the Genetics in Rare Diseases: A Genomic Odyssey

edited by

Klaus Brusgaard

submission deadline 20 Feb 2026 | 1 articles | Viewed by 859 | Submission Open

Keywords: novel discoveries in rare disorders; polygenic risk scores; mosaicism; protein interaction; tools utilized to engineer DNA; somatic variants; patient advocacy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Diversity of Life: Light to Heavy Metal Coordination Compounds of Biological Relevance

edited by

Ivayla Pantcheva

submission deadline 20 Feb 2026 | 1 articles | Viewed by 846 | Submission Open

Keywords: coordination compounds; metal-based drugs; antimicrobial; anti-inflammatory; antiviral agents; cancer therapy; drug delivery systems

(This special issue belongs to the Section Biochemistry)

Molecular Research of Gut Microbiota in Human Health and Diseases

edited by

Juan Francisco Martínez-Blanch

submission deadline 20 Feb 2026 | Viewed by 825 | Submission Open

Keywords: gut microbiota; gut metabolites; gastroenterology; microbiology; inflammation; human diseases

(This special issue belongs to the Section Molecular Microbiology)

Biomechanics and Molecular Research on Glioblastoma: 2nd Edition

edited by

Lorenzo Corsi

submission deadline 20 Feb 2026 | 1 articles | Viewed by 780 | Submission Open

Keywords: GBM; molecular pathways; biomechanics; oncogene; cancer; microenvironment; drug targeting; diagnostic; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Omics-Driven Unveiling of the Structure and Function of Nanoparticles

edited by

Elva Morretta

submission deadline 20 Feb 2026 | 1 articles | Viewed by 759 | Submission Open

Keywords: nanoparticles; nanotechnology; drug delivery; protein corona; proteomics; nano-proteomics; matabolomics; lipidomics

(This special issue belongs to the Section Molecular Biophysics)

Therapeutic Potential: Exploring Membrane Transporters and Channels as Drug Targets

edited by

Jinwei Zhang

submission deadline 20 Feb 2026 | Viewed by 749 | Submission Open

Keywords: membrane transporters; channels; drug targets; therapeutic potential; neurological disorders; metabolic syndromes; methodologies; mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Feature Papers in ‘Physical Chemistry and Chemical Physics’: Fourth Edition

edited by

Dongho Kim

submission deadline 20 Feb 2026 | 3 articles | Viewed by 745 | Submission Open

Keywords: heterogeneous structures; alignment and surface phenomena; quantum theory; mathematical physics; statistical and classical mechanics; molecular structure; chemical kinetics; laser physics; dynamics; kinetics; photochemistry; spectroscopy; exciton dynamics; statistical mechanics; thermodynamics; electrochemistry; catalysis; surface science; quantum mechanics; theoretical developments; fundamental aspects of catalysis; solar energy conversion; polymer dynamics

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Mechanisms Regulating Plant Development and Cell Function

edited by

Tarek Alshaal

submission deadline 20 Feb 2026 | Viewed by 732 | Submission Open

Keywords: cell function; cell polarity; tissue organization; transporter; localization

(This special issue belongs to the Section Molecular Plant Sciences)

Drug Therapy of Systemic Lupus Erythematosus

edited by Dionysis Nikolopoulos

submission deadline 20 Feb 2026 | 1 articles | Viewed by 703 | Submission Open

Keywords: systemic lupus erythematosus; treatment; drugs; tailored strategies; precision medicine; biologics; cell therapy; randomized clinical trials

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Interactions and Advanced Computational Methods for Biomolecular Systems

edited by

Amar Singh

submission deadline 20 Feb 2026 | 1 articles | Viewed by 696 | Submission Open

Keywords: molecular interactions; biological systems; computational biology; protein– protein interactions; protein docking; bioinformatics; structural modeling; multiscale modeling techniques

(This special issue belongs to the Section Molecular Biophysics)

Molecular Mechanisms of Nanomaterial-Mediated Immune Modulation

edited by

Ivan Kempson

submission deadline 20 Feb 2026 | Viewed by 683 | Submission Open

Keywords: nanomaterial; immune modulation; immunological responses

(This special issue belongs to the Section Molecular Nanoscience)

Transcription Factors in Plant Gene Expression Regulation, 2nd Edition

edited by

Piotr Szymczyk

submission deadline 20 Feb 2026 | 1 articles | Viewed by 639 | Submission Open

Keywords: plant trans-factor; cis-active sequence; post-translational modification; dimerization and oligomerization; DNA modules

(This special issue belongs to the Section Molecular Plant Sciences)

Iron and Sulfur in Plants, 4th Edition

edited by

Stefania Astolfi

and

Silvia Celletti

submission deadline 20 Feb 2026 | Viewed by 635 | Submission Open

Keywords: biofortification; Fe– S clusters; iron; iron deficiency; metabolites; methionine; nutrient interaction; root exudates; strategy I; strategy ii; sulfur; sulfur deficiency

(This special issue belongs to the Section Molecular Plant Sciences)

Novel Insights into Buckwheat Reproductive Biology

edited by

Agnieszka Płażek

submission deadline 20 Feb 2026 | 1 articles | Viewed by 633 | Submission Open

Keywords: antioxidant properties; biotechnological methods; embryology; seed chemical composition; yield

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms Linking Obesity to Atherosclerosis Pathogenesis

edited by

Weibin Shi

submission deadline 20 Feb 2026 | 1 articles | Viewed by 598 | Submission Open

Keywords: obesity; overweight; atherosclerosis; coronary artery disease; obesity paradox; body mass index; visceral fat

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Parasitic Infection

edited by Marcin Wiśniewski and

Piotr Bąska

submission deadline 20 Feb 2026 | 1 articles | Viewed by 545 | Submission Open

Keywords: parasitic infections; host– parasite interactions; parasite genomics; drug-resistance mechanisms; transcriptomics; proteomics; diagnostic tools; immune evasion; therapeutic strategies

(This special issue belongs to the Section Molecular Microbiology)

Research on Alloy Materials Microstructure and Their Functionalization

edited by

Ozkan Gokcekaya

and Celaletdin Ergun

submission deadline 20 Feb 2026 | 1 articles | Viewed by 533 | Submission Open

Keywords: alloy design; microstructure; production methods; additive manufacturing; sol– gel process; biofunctional materials; magnetic properties; nanoparticles; ceramics; composites

(This special issue belongs to the Section Materials Science)

Advances in Pathogenesis and Treatment of Skin Cancer (2nd Edition)

edited by

Enrica Flori

Giorgia Cardinali

and

Vittoria Maresca

submission deadline 20 Feb 2026 | 1 articles | Viewed by 528 | Submission Open

Keywords: melanoma; squamous cell carcinoma; basal cell carcinoma; tumor microenvironment; epithelial– mesenchymal transition (EMT) process; ultraviolet radiation; oxidative stress; bioactive modulators; signal transduction pathways

(This special issue belongs to the Section Molecular Oncology)

Molecular and Neuromuscular Mechanisms in Skeletal Muscle Aging, 2nd Edition

edited by

Rosa Mancinelli

submission deadline 20 Feb 2026 | 1 articles | Viewed by 487 | Submission Open

Keywords: aging; sarcopenia; neuromuscular junction; molecular muscle modifications; myokines

(This special issue belongs to the Section Molecular Biology)

Advances in Vitiligo: From Mechanisms to Treatment Innovations

edited by Hyun Jeong Ju

submission deadline 20 Feb 2026 | 1 articles | Viewed by 483 | Submission Open

Keywords: autoimmune disease; cytokine signaling; depigmentation; immunotherapy; melanocyte regeneration; microbiome; oxidative stress; vitiligo

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Therapeutic Strategies of Colorectal Cancer

edited by

Daniel Gabriel Pons

submission deadline 20 Feb 2026 | 1 articles | Viewed by 440 | Submission Open

Keywords: colorectal cancer; tumor microenvironment; biomarkers; intercellular communication; therapeutic strategies

(This special issue belongs to the Section Molecular Oncology)

New Advances in Cystinosis from Basic to Clinical Research

edited by Francesco Bellomo

submission deadline 20 Feb 2026 | Viewed by 427 | Submission Open

Keywords: cystinosis; kidney; Fanconi syndrome; muscles; eyes; autophagy; bioenergetics; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Redox Systems in Humans, Animals, Plants and Aquatic Ecosystems and Their Microbiomes

edited by

Eugenio Luigi Iorio

submission deadline 20 Feb 2026 | Viewed by 405 | Submission Open

Keywords: redox systems; aging and disease; nutraceuticals; probiotics; animals; plants; aquatic ecosystems; microbiomes

(This special issue belongs to the Section Molecular Biology)

Pathophysiological Insights, Biomarkers and New Therapeutic Strategies in Immune-Mediated Disorders and Neurodegenerative Diseases

edited by

Eleonora Virgilio

submission deadline 20 Feb 2026 | Viewed by 393 | Submission Open

Keywords: neurodegeneration; neuroimmunology; inflammation; biomarkers; treatment; pathophysiology; multiple sclerosis; myasthenia gravis; neurodegenerative disease

(This special issue belongs to the Section Molecular Immunology)

Displaying special issue 3201-3250 on page 65 of 68.

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