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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Gut Microbiota in Human Disease and Health: 2nd Edition

edited by

Silvia Turroni

and

Federica D'Amico

submission deadline 20 Aug 2026 | Viewed by 187 | Submission Open

Keywords: gut microbiota; human disease; human health; omics; microbiota– host interactions; microbiota manipulation

(This special issue belongs to the Section Molecular Microbiology)

Cellulose and Its Applications, 2nd Edition

edited by

Suresh Valiyaveettil

and Ce Sun

submission deadline 20 Aug 2026 | Viewed by 186 | Submission Open

Keywords: cellulose; biomedical applications; nanocomposites; biodegradable polymers; water purification; nanocellulose

(This special issue belongs to the Section Macromolecules)

The Cellular and Molecular Mechanisms of Central Nervous System Injury

edited by

Laurent R. Gauthier

and

José R. Pineda

submission deadline 20 Aug 2026 | Viewed by 186 | Submission Open

Keywords: central nervous system damage; CNS; oxidative stress; DNA damage responses; neuroregeneration; blood– brain barrier disruption

(This special issue belongs to the Section Molecular Neurobiology)

Evolutionary Drivers and Adaptive Mechanisms in Algal Organellar Genomes

edited by

Feng Liu

submission deadline 20 Aug 2026 | Viewed by 185 | Submission Open

Keywords: organellar genome of algae; molecular evolution; secondary structure of intron; evolutionary driving force; horizontal gene transfer

(This special issue belongs to the Section Molecular Plant Sciences)

Pulmonary Hypertension: From Molecular Pathophysiology to New Therapeutic Approaches

edited by Claudia Mickael

submission deadline 20 Aug 2026 | Viewed by 185 | Submission Open

Keywords: pulmonary hypertension; molecular pathophysiology; vascular remodelling; targeted therapies; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Lipopolysaccharide as a Drug Target

edited by

Martina Schmidt

submission deadline 20 Aug 2026 | Viewed by 180 | Submission Open

Keywords: tissue barriers; neuroinflammation; macrophages; microglia; organoids; scaffolds; infections; cry-EM

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Pathology and Treatment of Hepatocellular Carcinoma

edited by

Simona Gurzu

submission deadline 20 Aug 2026 | Viewed by 179 | Submission Open

Keywords: hepatocellular carcinoma; cholangiocarcinoma; angiosarcoma; metastases; biomarkers; immunohistochemistry; genetics; clinical trial

(This special issue belongs to the Section Molecular Oncology)

Rewriting Medicine: Stem Cells and Regeneration

edited by

Tadahisa Sugiura

submission deadline 20 Aug 2026 | Viewed by 177 | Submission Open

Keywords: regenerative medicine; stem cell biology; stem cell therapy; induced pluripotent stem cell; tissue engineering

(This special issue belongs to the Section Molecular Biology)

MicroRNAs as Biomarkers in Chronic Diseases

edited by

Xiao Wang

submission deadline 20 Aug 2026 | Viewed by 174 | Submission Open

Keywords: microRNA; biomarker; chronic diseases; cancer; cardiovascular diseases; psychiatric conditions

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Tumor Viruses: Infection, Carcinogenesis, and Treatment

edited by

Sherif T.S. Hassan

submission deadline 20 Aug 2026 | Viewed by 172 | Submission Open

Keywords: tumor viruses; viral oncogenesis; EBV; HPV; KSHV; HBV; HCV; HTLV-1; and MCPyV; virus-associated cancers; merging oncoviruses; viral latency; immune evasion; antiviral therapy; immunotherapy; cancer vaccines; gene-editing technologies

(This special issue belongs to the Section Molecular Microbiology)

Systems Approaches to Diabetic Complications

edited by

Paola Pontrelli

submission deadline 20 Aug 2026 | Viewed by 171 | Submission Open

Keywords: diabetes; diabetic complications; molecular mechanisms; precision medicine

(This special issue belongs to the Section Molecular Biology)

Molecular Perspective of Alzheimer’s Disease

edited by

Philippe Poindron

submission deadline 20 Aug 2026 | Viewed by 161 | Submission Open

Keywords: Alzheimer’ s disease; amyloid peptide (toxic conformation); mutations (gamma-secretase); GWAS; risk factors; new treatment (monoclonal antibodies)

(This special issue belongs to the Section Molecular Neurobiology)

Ion Regulation in Human Pathophysiology

edited by

Lars Kaestner

submission deadline 20 Aug 2026 | Viewed by 160 | Submission Open

Keywords: ion channels; ion gradients; membrane potential; action potential; ion pumps; uniporter; co-transporter; patch-clamp; ion flux; concentration gradient; ion stores; physiological processes; pathophysiological processes

(This special issue belongs to the Section Molecular Biology)

Plant-Based Early Therapeutics for Parasitic Infections Combined with Functional Modern Diagnosis Methods

edited by

Lee Tian Chang

submission deadline 20 Aug 2026 | Viewed by 160 | Submission Open

Keywords: active phytocompounds; antiparasitic agents; artificial intelligence; early diagnosis early treatment; life cycle; medicinal plants; parasite and vector; phytogenic feed additives; vision recognition

(This special issue belongs to the Section Molecular Plant Sciences)

Symbiosis and Molecular Mechanisms in Water Treatment

edited by

Binghan Xie

submission deadline 20 Aug 2026 | Viewed by 159 | Submission Open

Keywords: microbiomics; water treatment; bioenergy recovery; emerging contaminant degradation; antibiotic resistance genes (ARGs); microalgae biotechnology

(This special issue belongs to the Section Molecular Microbiology)

RNA-Mediated Post-Transcriptional Regulation in Bacteria Roles of Small RNAs, Small Proteins, and RNA Modifications

edited by Karl M Thompson

submission deadline 20 Aug 2026 | Viewed by 156 | Submission Open

Keywords: bacterial post-transcriptional regulation; small RNAs (sRNAs); small open reading frames (smORFs); RNA modifications; epitranscriptomics

(This special issue belongs to the Section Molecular Biology)

Roles of Phytochemicals in Molecular Signaling Networks

edited by

Jui-Hung Yen

submission deadline 20 Aug 2026 | Viewed by 155 | Submission Open

Keywords: phytochemicals; molecular signaling pathways; inflammation; apoptosis; chronic diseases; cancer; cardiovascular diseases; structure– activity relationships

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Latest Molecular Insights into Animal Nutrition

edited by

Bin Feng

submission deadline 20 Aug 2026 | Viewed by 152 | Submission Open

Keywords: reproduction; animal production; development; immunity; emissions; digestion efficiency; microbiome; metabolism; molecular signaling; nutritional strategies

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Medicinal Value of Plant Extracts

edited by

Myrna Déciga-Campos

and

Rosa Ventura-Martínez

submission deadline 20 Aug 2026 | Viewed by 150 | Submission Open

Keywords: medicinal plant; essential oil; cancer; diabetes; pain; inflammation; neurodegenerative diseases; metabolites; bioactive compounds; toxicity; safety; mutagenicity; genotoxicity; biological evaluations; efficacy; molecular

(This special issue belongs to the Section Molecular Pharmacology)

Intracellular Host-Bacteria Dynamics: Unraveling the Molecular Basis

edited by

Apichai Tuanyok

submission deadline 20 Aug 2026 | Viewed by 149 | Submission Open

Keywords: intracellular bacteria; granuloma; immune invasion; Mycobacterium tuberculosis; Burkholderia pseudomallei; Francisella; Brucella; Listeria; Coxiella

(This special issue belongs to the Section Molecular Microbiology)

DNA Damage, Genome Stability and the Human Disease

edited by

Fiammetta Verni

submission deadline 20 Aug 2026 | Viewed by 148 | Submission Open

Keywords: DNA damage; human diseases; DNA repair; genomic instability; therapeutic strategies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Mechanisms of Action of Environmental Neurotoxicants During Critical Periods of Brain Development

edited by

Yael Abreu-Villaça

submission deadline 20 Aug 2026 | Viewed by 148 | Submission Open

Keywords: environmental neurotoxicants; developmental neurotoxicity; critical windows; animal models; early exposure; long-term programming

(This special issue belongs to the Section Molecular Neurobiology)

Current Research on Phenolic Profiles and Anti-Inflammatory Activities of Plants

edited by Chi-Rei Wu and Li-Wei Lin

submission deadline 20 Aug 2026 | Viewed by 147 | Submission Open

Keywords: plants; phenolic profiles; inflammation; cardiovascular disorders; cancer; diabetes; neurodegenerative disorders

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Multiple Myeloma: Cancer Therapy and the Tumour Microenvironment

edited by Ruba Al Abdulla

submission deadline 20 Aug 2026 | Viewed by 146 | Submission Open

Keywords: multiple myeloma; cancer resistance; therapeutic strategies; stroma cells; cancer microenvironment; cancer immunity

(This special issue belongs to the Section Molecular Oncology)

Latest Advances in Pituitary Endocrinology

edited by

Antonio M. Picó

and Cristina Lamas

submission deadline 20 Aug 2026 | Viewed by 138 | Submission Open

Keywords: pituitary tumors; hypopituitarism; growth and puberty disorders; acromegaly; Cushing’ s disease and silent corticotroph tumors; silent pituitary tumors; hypophysitis; molecular endocrinology and transcription factors; hormone resistance; precision endocrinology

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Predictive, Prognostic Biomarkers and Therapeutic Targets of Breast Cancer: Second Edition

edited by Antonella Ciabattoni and Fabiana Gregucci

submission deadline 20 Aug 2026 | Viewed by 135 | Submission Open

Keywords: radiotherapy; breast cancer; stereotactic body radiotherapy; brain radiosurgery; target therapy; immunotherapy; tailored systemic therapy

(This special issue belongs to the Section Molecular Oncology)

New Molecular Insights into Antimicrobial Peptides

edited by

Gloria Bua

submission deadline 20 Aug 2026 | Viewed by 128 | Submission Open

Keywords: antimicrobial peptides; mode of action; molecular mechanism of biological activity; molecular targets; molecular modeling; structure– activity relationship

(This special issue belongs to the Section Molecular Microbiology)

Macrophage Dysfunction and Cytokine Storm in Pulmonary Disorders

edited by

Elżbieta Rutkowska

submission deadline 20 Aug 2026 | Viewed by 122 | Submission Open

Keywords: macrophage dysfunction; cytokine storm; lung diseases

(This special issue belongs to the Section Molecular Immunology)

Vitamin D in Reproductive Disorders: Determinants, Metabolism, and Downstream Biological Mechanisms

edited by

Eugenia Mata-Greenwood

submission deadline 20 Aug 2026 | Viewed by 115 | Submission Open

Keywords: vitamin D; perinatal corticosteroids; placental insufficiency; intrauterine growth restriction; cortisol metabolism

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neural Signaling: The Perspective of Molecular Genetics

edited by

Chunlai Wu

submission deadline 20 Aug 2026 | Viewed by 108 | Submission Open

Keywords: molecular neurogenetics; neural signaling; gene editing; neural circuits; neural plasticity; neurodegenerative disorders; single-cell technologies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Sarcomeric Proteins in Health and Disease: Progress and Prospects

edited by

Thomas C. Irving

submission deadline 20 Aug 2026 | Viewed by 99 | Submission Open

Keywords: sarcomeric proteins; muscle contraction; sarcomere

(This special issue belongs to the Section Molecular Biophysics)

Cancer Stem Cells as Key Immunotherapy Targets

edited by Cosmin Andrei Cismaru

submission deadline 20 Aug 2026 | Viewed by 91 | Submission Open

Keywords: cancer stem cells; immunotherapy; immune escape; tumor antigens; cancer recurrence

(This special issue belongs to the Section Molecular Immunology)

New Research on Toxicology Research Models

edited by

Cláudia Maria Rosa Ribeiro

and

María Carolina Rocha-Pereira

submission deadline 20 Aug 2026 | Viewed by 83 | Submission Open

Keywords: contaminants of emerging concern; aquatic organisms; in vitro; in vivo; mammalian approaches; mechanisms of toxicity; environmental risk assessment; one health

(This special issue belongs to the Section Molecular Toxicology)

Effects of Radiation in Health and Disease

edited by

Raffaella Lazzarini

submission deadline 20 Aug 2026 | Viewed by 80 | Submission Open

Keywords: extremely low-frequency magnetic fields; proteins and gene interaction; ionizing and non-ionizing radiations

(This special issue belongs to the Section Molecular Biology)

Focus on Chemoradiation Resistance: The Challenge of Cancer Therapy

edited by

Karl Reinhard Aigner

and Hendrikx Marc José Henri

submission deadline 20 Aug 2026 | Viewed by 79 | Submission Open

Keywords: genetic; epigenetic; and metabolic determinants of chemoradiation resistance; tumor microenvironmental influences and immune system interactions; DNA damage response pathways and novel radiosensitizers/chemosensitizers; predictive and prognostic biomarkers for treatment response; emerging therapeutic combinations and personalized medicine strategies; concentration-dependent therapy and chemotherapy optimization; intra-arterial infusion and isolated perfusion chemotherapy; quality of life

(This special issue belongs to the Section Molecular Oncology)

New Therapies for CNS Diseases Targeting Biogenic Amines and Their Receptors

edited by

Dorota Łażewska

and

Anna Stasiak

submission deadline 20 Aug 2026 | Viewed by 15 | Submission Open

Keywords: neurotransmitters; biogenic amines; receptors; ligands (antagonists; agonists; inverse agonists; biased ligands); neurodegenerative diseases (e.g.; Alzheimer's disease; Parkinson's disease); neuroinflammation; CNS cancers; autoimmune disease (e.g.; multiple sclerosis); neurological diseases; mental illness (schizophrenia; depression); epilepsy; pain; in vitro studies; in silico studies (ADMET; molecular modelling); in vivo studies

(This special issue belongs to the Section Molecular Neurobiology)

Unknown Pathogenesis of Musculoskeletal Diseases and Basic Sciences: The Role of New Technologies

edited by

Gianluigi Pasta

submission deadline 20 Aug 2026 | Viewed by 14 | Submission Open

Keywords: AI; musculoskeletal diseases; pathogenesis; basic sciences; molecular mechanisms; genetics; immunology; biomechanics; translational research; experimental models; tissue engineering

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Metallic Biomaterials: From Research to Clinical Translation

edited by Ke Yang

submission deadline 20 Aug 2026 | Viewed by 7 | Submission Open

Keywords: metallic biomaterials; bio-functionality; biocompatibility; mechanical properties; clinical application

(This special issue belongs to the Section Materials Science)

Natural Antioxidants: Molecular Mechanisms, Formulations and Therapeutic Perspectives

edited by

Lavinia Anamaria Purza

submission deadline 20 Aug 2026 | Viewed by 4 | Submission Open

Keywords: natural antioxidants; oxidative stress; redox signaling; polyphenols; reactive oxygen species; bioactive compounds; nutraceuticals; phytochemicals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

miRNA in Physiology and Pathophysiology

edited by

Ivan Jovanović

submission deadline 21 Aug 2026 | Viewed by 31 | Submission Open

Keywords: microRNAs; gene regulation; physiology; pathophysiology; biomarkers; complex diseases; cancer

(This special issue belongs to the Section Molecular Genetics and Genomics)

Natural Compounds in Cancer Treatment and Prevention: Mechanisms, Evidence, and Clinical Perspectives

edited by Vitor Engracia Valenti

submission deadline 25 Aug 2026 | Viewed by 106 | Submission Open

Keywords: natural compounds; cancer treatment; cancer prevention; bioactive phytochemicals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Current Research on Lipidomics

edited by

Agata Kot-Wasik

submission deadline 25 Aug 2026 | Viewed by 64 | Submission Open

Keywords: lipids ; hyphenated chromatography– mass spectrometry ; biological samples ; sample preparation

(This special issue belongs to the Section Molecular Biology)

Circadian Clocks and Immunity: Unraveling the Rhythm of Immune Function

edited by Vincent Yuan and

Telma Quintela

submission deadline 25 Aug 2026 | Submission Open

Keywords: circadian rhythm; biological clocks; immune regulation; innate immunity; adaptive immunity; inflammation; chronotherapy; immune-metabolic regulation; tissue-resident immune cells; autoimmune disease

(This special issue belongs to the Section Molecular Immunology)

Neurotransmitter Dysregulation in Brain Disease: Focus on Epilepsy and Its Comorbidities

edited by

Giuseppe Di Giovanni

submission deadline 30 Aug 2026 | Viewed by 157 | Submission Open

Keywords: neurotransmitter dysregulation; epilepsy; addiction; serotonin; GABA; molecular neuroscience; neuropharmacology; brain networks

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms Fueling Glioblastoma Progression and Resistance: Emerging Therapeutic Opportunities

edited by

Anthony Lemarié

submission deadline 30 Aug 2026 | Viewed by 98 | Submission Open

Keywords: glioblastoma; cancer stem cells; radioresistance; chemoresistance; targeted therapies; tumor plasticity; tumor heterogeneity; invasion; immune escape

(This special issue belongs to the Section Molecular Neurobiology)

MiRNA Regulation in the Early PME/TME: The Role of Non-Cancer Cells and the ECM in Solid Tumours

edited by

Kurt Sartorius

submission deadline 30 Aug 2026 | Viewed by 90 | Submission Open

Keywords: microRNAs; early tumor microenvironment (TME); stromal/ECM interaction; vascularization; ECM remodelling; signalling pathways

(This special issue belongs to the Section Molecular Oncology)

Latest Advances in Antiparasitic Agents

edited by Olga S. Koutsoni and

Maria Agallou

submission deadline 30 Aug 2026 | Viewed by 80 | Submission Open

Keywords: parasite genomics; parasite proteomics; metabolic pathways; parasite– host interactions; drug targets; mechanisms of drug resistance

(This special issue belongs to the Section Molecular Pharmacology)

Evolutionary Genetics of Pathogens

edited by Leonardo Gabriel Panunzi

submission deadline 30 Aug 2026 | Viewed by 73 | Submission Open

Keywords: pathogenicity; genome evolution; horizontal gene transfer; virulence factors; comparative genomics; pangenome analysis mobile genetic elements; computational biology; machine learning; host– pathogen interactions

(This special issue belongs to the Section Molecular Genetics and Genomics)

Cardioprotective Mechanisms in Myocardial Ischemia

edited by Virginia Pérez and Verónica D’annunzio

submission deadline 30 Aug 2026 | Viewed by 58 | Submission Open

Keywords: myocardial ischemia; ischemia– reperfusion injury; cardioprotection; molecular signaling; oxidative stress; inflammation; cardiac remodeling; therapeutic targets; translational cardiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomarkers and Early Detection Strategies of Ovarian Tumors: 2nd Edition

edited by Lukasz Szafron

submission deadline 30 Aug 2026 | Viewed by 54 | Submission Open

Keywords: biomarker; ovarian cancer; borderline ovarian tumor; genetic variant; epigenetics; transciptomics; proteomics; metabolomics; ovarian tumor prevention; ovarian tumor treatment

(This special issue belongs to the Section Molecular Oncology)

Displaying special issue 3151-3200 on page 64 of 67.

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