Special Issue "Zebrafish 2.0: A Model for Toxicological Research"
Deadline for manuscript submissions: closed (1 April 2019)
Prof. Dr. Juliette Legler
1. Professor and Chair of Toxicology, Institute for Risk Assessment Sciences (IRAS), Utrecht University, Jeanette Donker-Voet Building, Yalelaan 104, room 1.059, 3584 CM UTRECHT, P.O. Box 80177, NL-3508 TD UTRECHT, The Netherlands 2. Honorary Professor of Toxicology and Environmental Health, Brunel University London
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Interests: environmental and human toxicology; molecular and cell biology; epigenetics; developmental biology; bioassay development and validation; endocrine disruption; zebrafish; in vitro models; fetal origins of disease; obesity; risk assessment
The zebrafish (Danio rerio) has long been used as a model species for the toxicity testing of chemicals. The zebrafish, however, offers considerably more as a model species and is now used in many different research fields including basic developmental biology, neurobiology, and immunology. Advances in genetic and epigenetic research of the zebrafish, including gene knockout and transgenesis technologies, allow for better understanding of molecular mechanisms of toxic action. The potential of zebrafish for modeling human diseases is becoming increasingly evident, and the availability of these models allows for increased understanding of the role of chemical exposure in human disease. In this Special Issue, we welcome contributions that show recent developments in zebrafish toxicity testing and drug discovery, such as novel endpoints, assays and testing strategies. Articles covering aspects of molecular and cellular mechanisms of action to effects on individual fish as well as multigenerational effects and population level impacts are invited. Contributions on high throughput screening, monitoring and safety assessment of chemicals are invited, as well as new insights on the effects in chemical exposure in zebrafish models of human diseases. Translational studies that employ molecular methods to enhance our understanding of human health or environmental risk assessment are also of interest.
Prof. Dr. Juliette Legler
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- toxicity testing
- developmental biology
- human health
- disease genetics
- hazard assessment
- risk assessment
- molecular mechanisms
- high throughput screening
- systems biology
- translational study