Special Issue "Achilles Curse and Remedy: Tendon Diseases from Pathophysiology to Novel Therapeutic Approaches"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 15 August 2020.
Interests: connective tissues; tendons and ligaments; tendon marker genes; tenomodulin; tendon stem/progenitor cells; tenogenic differentiation; tendon aging and degeneration; tendon rupture; tendon healing; tendon tissue engineering; in vitro 2D and 3D models; in vivo models (pre-clinical and transgene animal models); tendon functional outcome analyses
In Greek mythology, Achilles, the Greek hero, is almost invulnerable—except for his Achilles heel, whose injury resulted in his death. How could a tendon injury take such a prominent place in Greek mythology? This injury was obviously such a crucial and inexplicable event that it was extensively honored in the legendary Iliad of Homer. Presumably, the ancient Greeks had already asked themselves how it could have happened that the greatest tendon of man could suddenly break, even in a young, vigorous athlete. Tendons are dense connective tissues and critical components for the integrity and function of the musculoskeletal system, as they connect bone to muscle and transmit forces on which locomotion entirely depends. Due to the increasing age of our society and a rise in the engagement of young people in overuse activities or extreme sports, tendon diseases present major clinical and financial challenges in modern medicine. Inevitably, tendinopathies lead to the final stage disease that is tendon rupture, and once this happens, tendon natural healing is slow, often poorly responding to treatments and requiring prolonged rehabilitation in most cases. A major cause of tendon rupture is tendon tissue degeneration, a process that can be considered a failure of matrix adaptation and remodeling because of an imbalance between matrix decomposition and synthesis due to a variety of stresses and mechanical loads. There are three main hypotheses about the cause(s) of tendon degeneration: (1) mechanical overuse (via matrix), (2) neo-vascularization (via exogenous cells), and (3) cell and tissue aging (via endogenous cells). Most likely, all these three triggers cross-talk to and cross-react with one, another ultimately leading to the failure of the whole tendon unit. So far, there have been only a few approved treatments for tendinopathy that are targeted against specific molecular processes, and still, in most cases, there is little to no evidence of therapeutic effectiveness, especially in the long term. Regarding end-stage tendon rupture, there are two main clinical algorithms, namely, subjecting patients to surgical or conservative therapy, as both require months-long periods to achieve mostly partial and rarely full structural and functional tendon reconstitution.
Therefore, this Special Issue aims to embrace studies concentrating on endogenous tendon cells and their governing molecular pathways, the contribution of exogenous cells (vascular, inflammatory, and neuronal), and the significance of niche structural composition and biomechanical properties leading to tendon diseases, as well as studies focusing on novel tendon medicinal and tissue engineering therapeutic approaches with the overall goal to re-define the status quo in the field of tendon disease and therapy.
Prof. Dr. Denitsa Docheva
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- tendon rupture
- tendon healing
- tendon stem/progenitor cells
- inflammation and immune cells
- vasculature and innervation
- extracellular matrix
- medicinal molecular targets
- tendon tissue engineering
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Spectrum of tendon pathologies: triggers, trails and end-state
Authors: Sara Steinmann and Denitsa Docheva
Title: Detection of age-related changes in tendon molecular composition by Raman spectroscopy – potential for rapid, non-invasive assessment of susceptibility to injury
Authors: Yin, N.-H.; Parker, A.W.; Matousek, P.; Birch, H.L.
Title: Development of neo-epitope assays for the detection of equine tendon disease
Authors: Smith RKW, Onnerfjord P*, Holmgren K*, Dudhia J
Title: Multifaceted EGR1 transcription factor as a regulator of matrix production in connective tissues
Authors: Emmanuelle Havis and Delphine Duprez
Title: Ultrasound-guided interventions in chronic Achilles tendinopathy: rational basis of therapies, molecular and structural effects, clinical efficacy
Authors: Christelle Darrieutort-Laffite, etc.