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Int. J. Mol. Sci. 2018, 19(12), 3949; https://doi.org/10.3390/ijms19123949

Activated Rho GTPases in Cancer—The Beginning of a New Paradigm

Rudbeck Laboratory, Department of Immunology, Genetics and Pathology (IGP), Uppsala University, SE 751 85 Uppsala, Sweden
Received: 6 November 2018 / Revised: 30 November 2018 / Accepted: 5 December 2018 / Published: 8 December 2018
(This article belongs to the Special Issue Small GTPases)
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Abstract

Involvement of Rho GTPases in cancer has been a matter of debate since the identification of the first members of this branch of the Ras superfamily of small GTPases. The Rho GTPases were ascribed important roles in the cell, although these were restricted to regulation of cytoskeletal dynamics, cell morphogenesis, and cell locomotion, with initially no clear indications of direct involvement in cancer progression. This paradigm has been challenged by numerous observations that Rho-regulated pathways are often dysregulated in cancers. More recently, identification of point mutants in the Rho GTPases Rac1, RhoA, and Cdc42 in human tumors has finally given rise to a new paradigm, and we can now state with confidence that Rho GTPases serve as oncogenes in several human cancers. This article provides an exposé of current knowledge of the roles of activated Rho GTPases in cancers. View Full-Text
Keywords: Rho GTPases; atypical Rho GTPases; oncogenes; actin; stress fibers; cell migration Rho GTPases; atypical Rho GTPases; oncogenes; actin; stress fibers; cell migration
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Aspenström, P. Activated Rho GTPases in Cancer—The Beginning of a New Paradigm. Int. J. Mol. Sci. 2018, 19, 3949.

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