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Review

Rac GTPases in Hematological Malignancies

1
Department of Internal Medicine III with Hematology, Medical Oncology, Hemostaseology, Infectious Disease, Rheumatology, Oncologic Center, Salzburg Cancer Research Institute—Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR), Paracelsus Medical University, Cancer Cluster Salzburg, 5020 Salzburg, Austria
2
Department of Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine and Medical Center, University of Freiburg, 79106 Freiburg, Germany
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(12), 4041; https://doi.org/10.3390/ijms19124041
Received: 11 November 2018 / Revised: 11 December 2018 / Accepted: 12 December 2018 / Published: 14 December 2018
(This article belongs to the Special Issue Small GTPases)
Emerging evidence suggests that crosstalk between hematologic tumor cells and the tumor microenvironment contributes to leukemia and lymphoma cell migration, survival, and proliferation. The supportive tumor cell-microenvironment interactions and the resulting cellular processes require adaptations and modulations of the cytoskeleton. The Rac subfamily of the Rho family GTPases includes key regulators of the cytoskeleton, with essential functions in both normal and transformed leukocytes. Rac proteins function downstream of receptor tyrosine kinases, chemokine receptors, and integrins, orchestrating a multitude of signals arising from the microenvironment. As such, it is not surprising that deregulation of Rac expression and activation plays a role in the development and progression of hematological malignancies. In this review, we will give an overview of the specific contribution of the deregulation of Rac GTPases in hematologic malignancies. View Full-Text
Keywords: Rac GTPases; leukemia; lymphoma; microenvironment; cancer; migration; survival; proliferation Rac GTPases; leukemia; lymphoma; microenvironment; cancer; migration; survival; proliferation
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MDPI and ACS Style

Durand-Onaylı, V.; Haslauer, T.; Härzschel, A.; Hartmann, T.N. Rac GTPases in Hematological Malignancies. Int. J. Mol. Sci. 2018, 19, 4041. https://doi.org/10.3390/ijms19124041

AMA Style

Durand-Onaylı V, Haslauer T, Härzschel A, Hartmann TN. Rac GTPases in Hematological Malignancies. International Journal of Molecular Sciences. 2018; 19(12):4041. https://doi.org/10.3390/ijms19124041

Chicago/Turabian Style

Durand-Onaylı, Valerie; Haslauer, Theresa; Härzschel, Andrea; Hartmann, Tanja N. 2018. "Rac GTPases in Hematological Malignancies" Int. J. Mol. Sci. 19, no. 12: 4041. https://doi.org/10.3390/ijms19124041

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