Reactive Oxygen Species—Related Materials and Medicine, Volume II

Dear Colleagues, 

Reactive oxygen species (ROS) such as peroxides, superoxide, hydroxyl radical, singlet oxygen, and alpha-oxygen are under a chemically reactive state. Even though ROS are a byproduct from the metabolism of oxygen in cells, they play a critical role in cellular signaling processes and homeostasis. The biological roles of ROS in particular are a double-edged sword. When ROS exist in cells within the appropriate level, they frequently contribute to the proliferation, migration, and homeostasis of cells. However, excessive levels of ROS normally induce cell cycle arrest, apoptosis, necrosis, or genetic alterations in biological systems and then affect the structure of cells.

From this point of view, many types of scientists, such as molecular biologists, have been investigating the molecular process of ROS production and their action in normal cells or cancer cells, while other scientists have been developing novel medicines and nanomaterials that produce ROS or are modified by ROS. For example, ROS-producing agents and/or ROS-sensitive nanomaterials in chemotherapeutic approaches are to produce excessive ROS in cells and kill cancer cells. ROS generation in cells is increasingly finding itself in the spotlight in various fields of science.

Some of the topics around reactive oxygen species to be tackled in this Special Issue include but are not limited to:

• Molecular mechanism of ROS generation and its action in cells;
• ROS-producing agents;
• ROS-sensitive nanomaterials;
• ROS-mediated drug delivery system;
• ROS-mediated diagnosis of disease;
• Photodynamic therapy.

Prof. Dr. Jeong Young-IL
Guest Editor

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