Protein Kinases: Function, Substrates, and Implication in Diseases

Dear Colleagues,

Protein kinases represent an important family of enzymes involved in the regulation of many cellular processes. They phosphorylate proteins, and in turn, regulate their biological activities. As phosphorylation is a most frequent reversible post-translational modification, it has to be dynamically regulated. When defining the impact of phosphorylation on protein activities, it is clear that the presence or absence of phosphate groups change the conformation of the protein, and thus modify its activities. From that view, it has become clear that protein kinases play specific regulatory roles throughout the cell, and their defects may result in the development of various diseases.

For this Special Issue, we look forward to receiving review articles as well as original research and methodological manuscripts related to understanding the biological functions of protein kinases, with a special focus on the dynamic nature of their regulatory activities.

Dr. Lubos Cipak
Guest Editor

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