Molecular Research in Primary Osteoporosis

Dear Colleagues,

Primary osteoporosis, a frequent disorder of bone remodeling process, is characterized by the decrease in bone mass and mineral density (BMD). Because of the impairment in bone quality and microarchitecture, osteoporotic patients are more exposed to low-energy fractures in long bones and vertebrae than normal population. Primary osteoporosis predominantly affects postmenopausal women (type I osteoporosis) and the elderly population (type II osteoporosis); therefore, this skeletal disorder is often considered as an aging-associated disease. However, an idiopathic juvenile osteoporosis that may occur in children and young adults has also been described.

The high prevalence of primary osteoporosis increased the interest of the research to shed light on its pathogenesis trying to improve its current prevention and treatment methods.

In line with this aim, in this Special Issue, we welcome molecular- or cellular-level original research articles and comprehensive reviews relating to molecular pathophysiology and targeted therapies of this topic. Submissions of clinical studies with biomolecular experiments or pathological research with case sample data are also welcomed.

Dr. Manuela Dicarlo
Dr. Angela Oranger
Guest Editors

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