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Special Issue "Polyphenols: Nutrition, Physiology, Metabolism and Health Benefits 2019"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 August 2019

Special Issue Editors

Guest Editor
Dr. Gerard Aragonès

Universitat Rovira i Virgili, Department of Biochemistry and Biotechnology, Nutrigenomics Research Group, Tarragona, Spain
Website | E-Mail
Interests: bioactive compounds; chrono-nutrition; energy homeostasis; epigenetics; functional foods; gut microbiota; leptin signalling; metabolism nutrigenomics; obesity xenohormesis
Guest Editor
Dr. Letizia Bresciani

The Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, Department of Veterinary Science, University of Parma, 43125 Parma, Italy
Website | E-Mail
Interests: bioactivity; bioavailability; colonic metabolites; gut microbiota; inter-individual variability; metabolism; pharmacokinetics; phytochemicals; plant based-foods and beverages; supplements; TMAO; urinary excretion

Special Issue Information

Dear Colleagues,

Most polyphenols cannot be absorbed as such, and need some structural modification prior absorption. The absorption of a minimal part of the ingested polyphenols occurs in the first gastro-intestinal tract, whereas the largest part reaches the colon, where polyphenolic compounds are metabolized by the host microbiota. In the large intestine, the unmetabolized polyphenols undergo ring fission, leading to the production of smaller molecules, which in turn can be subject to reduction, decarboxylation, demethylation and dehydroxylation reactions, prior to efficient absorption. Once absorbed, polyphenols and their derived microbial metabolites follow the common metabolic pathway of exogenous organic substances, undergoing cellular and/or hepatic phase II metabolism, resulting in the formation of conjugated metabolites, such as methyl-, sulfate- and/or glucuronide-derivatives. From the liver, potential bioactive metabolites enter systemic circulation prior urinary excretion. The understanding of the absorption efficacy, the polyphenol–gut microbiota interactions and the gut microbial bioconversion capability could provide more insight into the human metabolism and the bioavailability of bioactive polyphenols and represent a necessary step to further elucidate the potential health effects of polyphenols and their derived metabolites. Moreover, the inter-individual variability in the production of specific metabolites also highlights the need for more efforts in this research field. With the support of IJMS, this Special Issue welcomes manuscripts from human and animal studies on the absorption and metabolism of polyphenols, as well as in vitro studies aimed at evaluating the potential polyphenol bioactivity and their molecular mechanisms of action.

Dr. Gerard Aragonès
Dr. Letizia Bresciani
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Bioactivity
  • Bioavailability
  • Metabolism
  • Pharmacokinetics
  • Polyphenols

Published Papers

This special issue is now open for submission.
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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