Pathophysiology, Molecular Mechanism and Therapeutic Strategies of Lysosomal Storage Disorders (LSD)

Dear Friends and Colleagues,

It gives us a pleasure to invite you to submit a paper to the forthcoming Special Issue of the International Journal of Molecular Sciences (IJMS) on Lysosomal Storage Disorders (LSD).

The IJMS is an open access, peer-reviewed journal with an IF of 4.18, and in the Special Issue on LSD, we welcome any high-quality contribution, which could be research articles from basic science to clinical studies, and we also invite reviews and case studies, with a common purpose to expand the current knowledge in this important area of LSDs. While, as 70 inherited metabolic disorders, they are considered rare, as a group, their incidence is about 1:5000, and they are all the more important given the many different types of underlying lysosomal dysfunction. In addition to the accumulation of the unmetabolized substrate (hence the concept of “storage” disorders), there are a variety of cellular and subcellular abnormalities, including endoplasmic reticulum stress, altered lipid trafficking, autophagy, inflammation, and autoimmune responses. Each of these pathological processes, alone or in combination, may lead to the development of novel therapeutic modalities, some of which have already changed natural history and the lives of patients with various diseases, such as Gaucher, Fabry, MPS and others, and in addition, these new treatments, including gene therapy, may also be of relevance to more common disorders, as we have witnessed from the relationship between Gaucher (both patients and carriers) and Parkinson’s diseases.

We would appreciate the submission of your contributions within the next 3 months, allowing us to get the full issue in print at the first quarter of 2020.

Prof. Ari Zimran
Prof. Shoshana Revel-Vilk
Guest Editors

Manuscript Submission Information

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