Special Issue "Osteoblast Differentiation and Activity in Skeletal Diseases"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 December 2021.
Bone is a complex tissue constituted by a mineral phase, hydroxyapatite, and an organic phase, mainly represented by collagen type I. Specialized cells are responsible for bone formation and remodeling and their coordinated activity is necessary to maintain bone homeostasis. Osteoblasts represent the bone forming cells, osteocyte are the orchestrator of bone remodeling through regulation of the other bone cells activity, by functioning as endocrine cells and by acting as mechanosensor, and osteoclasts, the bone resorbing cells. The bone cellular compartment is a dynamic environment and the cells crosstalk is fundamental to guarantee skeletal performance. Many evidences suggest that impairment in osteoblasts differentiation and/or activity are responsible for human diseases. The Special Issue, “Osteoblasts differentiation and activity in skeletal diseases” of the International Journal of Molecular Sciences will include a selection of research papers and reviews about various aspects of the molecular and cellular biology of osteoblasts, linking their impaired function to common and heritable skeletal diseases. How abnormal osteoblasts differentiation and activity influence bone modelling and remodeling and extracellular matrix mineralization will also be addressed.Prof. Dr. Antonella Forlino
Prof. Dr. Pierre Moffatt
Manuscript Submission Information
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- Secretory pathway
- Endoplasmic reticulum stress
- Signal transduction pathway
- Collagen type I
- Skeletal common disorders
- Skeletal heritable disorders
- Matrix vesicles