Serotonin Receptors in Human Health and Disease

Dear Colleagues, 

Serotonin (5-hydroxytryptamine (5- HT)) is a monoamine that acts as a neurotransmitter at neuronal synapses, but it also plays an important role in a variety of different organ systems. Its action is involved in the regulation of many physiological processes, including appetite, sleep, mood, nociception, stress response, blood pressure and vasomotility, heart rate and pulmonary function, gastrointestinal motility, micturition, and reproductive function. In addition, serotonin has also been found to play an important role in the development of the nervous system and various other organs. Serotonin acts through a group of receptors that are widely distributed in various organs. All serotonin receptors are G-protein-coupled receptors, with the exception of the 5-HT3 receptor, which is a ligand-gated ion channel. To date, 14 different subtypes have been identified, divided into 7 families (5-HT1-7), with different pharmacological effects. The signaling mechanism of serotonin receptors has also been found to depend on their conformational plasticity. Despite the extensive research, our knowledge of the amazing diversity of functions of serotonin and its receptors is far from complete, and much research is still needed to fill this gap. Therefore, we cordially invite researchers to submit review articles or original papers that contribute to our knowledge and understanding of the structure, function, and role of serotonin receptors in various pathologies. Potential topics include, but are not limited to, the following: functions in the nervous system; cardiovascular regulation; gastrointestinal and other visceral functions; mechanisms of action; role in development; future perspectives for pharmacotherapy.

Prof. Dr. Natalija Filipović
Guest Editor

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