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Special Issue "Myc Function and Regulation"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 September 2019

Special Issue Editors

Guest Editor
Dr. Paola Bellosta

Center of Integrative Biology, University of Trento, Via Sommarive 9, 38123 Trento, Italy
Website | E-Mail
Interests: Myc, development; growth; metabolism; tumor
Guest Editor
Dr. Yari Ciribilli

Centre for Integrative Biology (CIBIO), University of Trento, 38123 Mattarello, Italy
Website | E-Mail
Interests: transcription regulation; chemoresistance; cancer stem cells; epithelial-to-Mesenchymal Transition; breast cancer

Special Issue Information

Dear Colleagues,

Although more than 25 years have passed since the discovery of Myc, and over 34,000 publications have been written, what do we know about the function of this fundamental gene? This Special Issue will try to provide an overview of the work of many scientists who have helped to understand the physiological function of Myc, from its role in the control of animal development and organ growth, to its ability to rewire and control cellular metabolic pathways to drive the growth of tumors.

Dr. Paola Bellosta
Dr. Yari Ciribilli
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • organ growth
  • cell competition
  • development/evolution
  • ribosome biogenesis
  • stem cell/regeneration
  • chromatin modification
  • epigenetics
  • cancer metabolism
  • leukemia and others tumors

Published Papers (1 paper)

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Review

Open AccessReview
Emerging Roles of C-Myc in Cancer Stem Cell-Related Signaling and Resistance to Cancer Chemotherapy: A Potential Therapeutic Target Against Colorectal Cancer
Int. J. Mol. Sci. 2019, 20(9), 2340; https://doi.org/10.3390/ijms20092340
Received: 19 April 2019 / Revised: 29 April 2019 / Accepted: 9 May 2019 / Published: 11 May 2019
PDF Full-text (2230 KB) | HTML Full-text | XML Full-text
Abstract
Myc is a nuclear transcription factor that mainly regulates cell growth, cell cycle, metabolism, and survival. Myc family proteins contain c-Myc, n-Myc, and l-Myc. Among them, c-Myc can become a promising therapeutic target molecule in cancer. Cancer stem cells (CSCs) are known to [...] Read more.
Myc is a nuclear transcription factor that mainly regulates cell growth, cell cycle, metabolism, and survival. Myc family proteins contain c-Myc, n-Myc, and l-Myc. Among them, c-Myc can become a promising therapeutic target molecule in cancer. Cancer stem cells (CSCs) are known to be responsible for the therapeutic resistance. In the previous study, we demonstrated that c-Myc mediates drug resistance of colorectal CSCs using a patient-derived primary three-dimensional (3D) organoid culture. In this review, we mainly focus on the roles of c-Myc-related signaling in the regulation of CSCs, chemotherapy resistance, and colorectal cancer organoids. Finally, we introduce the various types of c-Myc inhibitors and propose the possibility of c-Myc as a therapeutic target against colorectal cancer. Full article
(This article belongs to the Special Issue Myc Function and Regulation)
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Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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