Special Issue "mTOR in Human Diseases"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (10 January 2019).
A printed edition of this Special Issue is available here.
Interests: mTOR; tumor growth; cell signaling; tumor microenvironment
Special Issues and Collections in MDPI journals
The mechanistic target of rapamycin (mTOR) is a highly conserved serine/threonine kinase that is ubiquitously expressed. It represents a major signaling intermediary that coordinates favorable environmental conditions with cell growth. Indeed, as part of two functionally distinct protein complexes, named mTORC1 and mTORC2, mTOR regulates a variety of cellular processes including protein, lipid and nucleotide synthesis as well as autophagy. Over the last two decades, major molecular advances have been made in mTOR signaling and have revealed the complexity of the events implicated in mTOR function and regulation. In parallel, the role of mTOR in diverse pathological conditions has also been identified including cancer, hamartoma, neurological and metabolic diseases. Accordingly, therapies that target mTOR benefit patients in various clinical settings. For instance, mTOR inhibitors are used as immunosuppressive drugs, in drug-eluting stents to prevent coronary restenosis following angioplasty or as anti-cancer treatments. It is therefore important to further fully investigate mTOR signaling at a molecular level in order to identify additional clinical opportunities of targeting mTOR in human disorders. This Special Issue of “mTOR in Human Diseases” will cover a selection of research articles related to mTOR in human pathologies. Emphasis will be given to the molecular aspects of mTOR in specific conditions. Experimental studies, review articles and commentaries are all welcome.
Dr. Olivier Dormond
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- cell signaling
- tuberous sclerosis