Special Issue "mTOR in Human Diseases"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (10 January 2019)
The mechanistic target of rapamycin (mTOR) is a highly conserved serine/threonine kinase that is ubiquitously expressed. It represents a major signaling intermediary that coordinates favorable environmental conditions with cell growth. Indeed, as part of two functionally distinct protein complexes, named mTORC1 and mTORC2, mTOR regulates a variety of cellular processes including protein, lipid and nucleotide synthesis as well as autophagy. Over the last two decades, major molecular advances have been made in mTOR signaling and have revealed the complexity of the events implicated in mTOR function and regulation. In parallel, the role of mTOR in diverse pathological conditions has also been identified including cancer, hamartoma, neurological and metabolic diseases. Accordingly, therapies that target mTOR benefit patients in various clinical settings. For instance, mTOR inhibitors are used as immunosuppressive drugs, in drug-eluting stents to prevent coronary restenosis following angioplasty or as anti-cancer treatments. It is therefore important to further fully investigate mTOR signaling at a molecular level in order to identify additional clinical opportunities of targeting mTOR in human disorders. This Special Issue of “mTOR in Human Diseases” will cover a selection of research articles related to mTOR in human pathologies. Emphasis will be given to the molecular aspects of mTOR in specific conditions. Experimental studies, review articles and commentaries are all welcome.
Dr. Olivier Dormond
Manuscript Submission Information
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- cell signaling
- tuberous sclerosis