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Special Issue "Exploring the Genotype–Phenotype Map: Regulatory Pathways"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 April 2020.

Special Issue Editor

Prof. Dr. Klaus Wimmers
E-Mail Website
Guest Editor
Leibniz Institute for Farm Animal Biology (FBN), Institute of Genome, Biology, Genomics Unit, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany
Tel. +49-38208-68700; Fax: +49-38208-68702
Interests: animal genomics; transcriptome; epigenome; animal health; animal welfare
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue addresses studies focussing on the interdependencies between various levels of the genotype–phenotype map. The previous Special Issue, “Exploring the Genotype–Phenotype Map to Explain Complex Traits”, covered articles reporting the effect of variation at the level of genomes (SNP, CNVs), transcriptomes, proteomes, and metabolomes on complex traits in humans and animals. This second call for contributions especially invites research papers and reviews reporting regulatory pathways within and between the various levels of the genotype–phenotypemap as well as the epigenetic mechanism mediating the effect of environmental effects on the recruitment of genetic information shaping the organismal phenotype.

Prof. Dr. Klaus Wimmers
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • network analysis
  • regulatory pathways
  • quantitative trait
  • epigenetics
  • non-coding RNAs
  • transcriptomics
  • proteomics
  • metabolomics
  • microarray
  • next generation sequencing

Published Papers (1 paper)

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Research

Open AccessArticle
Marek’s Disease Virus Infection Induced Mitochondria Changes in Chickens
Int. J. Mol. Sci. 2019, 20(13), 3150; https://doi.org/10.3390/ijms20133150 - 27 Jun 2019
Abstract
Mitochondria are crucial cellular organelles in eukaryotes and participate in many cell processes including immune response, growth development, and tumorigenesis. Marek’s disease (MD), caused by an avian alpha-herpesvirus Marek’s disease virus (MDV), is characterized with lymphomas and immunosuppression. In this research, we hypothesize [...] Read more.
Mitochondria are crucial cellular organelles in eukaryotes and participate in many cell processes including immune response, growth development, and tumorigenesis. Marek’s disease (MD), caused by an avian alpha-herpesvirus Marek’s disease virus (MDV), is characterized with lymphomas and immunosuppression. In this research, we hypothesize that mitochondria may play roles in response to MDV infection. To test it, mitochondrial DNA (mtDNA) abundance and gene expression in immune organs were examined in two well-defined and highly inbred lines of chickens, the MD-susceptible line 72 and the MD-resistant line 63. We found that mitochondrial DNA contents decreased significantly at the transformation phase in spleen of the MD-susceptible line 72 birds in contrast to the MD-resistant line 63. The mtDNA-genes and the nucleus-genes relevant to mtDNA maintenance and transcription, however, were significantly up-regulated. Interestingly, we found that POLG2 might play a potential role that led to the imbalance of mtDNA copy number and gene expression alteration. MDV infection induced imbalance of mitochondrial contents and gene expression, demonstrating the indispensability of mitochondria in virus-induced cell transformation and subsequent lymphoma formation, such as MD development in chicken. This is the first report on relationship between virus infection and mitochondria in chicken, which provides important insights into the understanding on pathogenesis and tumorigenesis due to viral infection. Full article
(This article belongs to the Special Issue Exploring the Genotype–Phenotype Map: Regulatory Pathways)
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