Special Issue "Focus on Exosome-Based Cell-Cell Communication in Health and Disease"
Deadline for manuscript submissions: closed (31 March 2019).
Prof. Dr. Riccardo Alessandro
Dipartimento di Biopatologia e Biotecnologie Mediche, Università degli studi di Palermo, sezione di Biologia e Genetica, Palermo, Italy
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Interests: cancer biology; exosomes; cancer cells; cell migration; cell adhesion; endothelial cells; cell biology; angiogenesis; signal transduction; cancer research; metastasis; tumor invasion
Dr. Aurelio Lorico
Over the last few years, a new and sophisticated mechanism of cell–cell communication, based on exosomes, has been described.
Exosomes are specialized vesicles of endosomal origin, released in the extracellular space by most cell types under physiological and pathological conditions. It has been widely described that these vesicles contain mRNAs, microRNAs, long non-coding RNAs, lipids, and proteins and that they can deliver these molecules among different cell types, thus affecting the phenotype of target cells.
Several studies have highlighted the role of exosomes in modulating cancer development and metastatic niche formation as well as in contributing to neurological, cardiological and rheumatological diseases. Due to their specific cell tropism, a peculiar property of these vesicles is the possibility of being engineered in order to modify their content, through the introduction of siRNAs, shRNAs, proteins, and drugs.
This Special Issue will discuss the recent advances in the field of exosomes as messengers of intercellular communication in both physiological and pathological conditions, pointing out the potential use of these nanovesicles for the delivery of therapeutic agents.Prof. Dr. Riccardo Alessandro
Dr. Aurelio Lorico
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- extracellular vesicles
- cell-cell signalling
- metastatic niche
- cardiovascular diseases
- neurological diseases