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Int. J. Mol. Sci. 2019, 20(8), 1848;

Extracellular Vesicles as Biological Shuttles for Targeted Therapies

Department of BioMedicine, Neuroscience and Advanced Diagnostics (Bi.N.D), Section of Biology and Genetics, University of Palermo, 90133 Palermo, Italy
IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano, 1/10, 40136 Bologna, Italy
Touro University Nevada College of Medicine, Henderson, NV 89014, USA
Mediterranean Institute of Oncology Foundation, 95029 Viagrande, Italy
Institute of Biomedicine and Molecular Immunology “A. Monroy”, National Research Council, 90146 Palermo, Italy
Authors to whom correspondence should be addressed.
Received: 24 March 2019 / Revised: 11 April 2019 / Accepted: 13 April 2019 / Published: 15 April 2019
(This article belongs to the Special Issue Focus on Exosome-Based Cell-Cell Communication in Health and Disease)
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The development of effective nanosystems for drug delivery represents a key challenge for the improvement of most current anticancer therapies. Recent progress in the understanding of structure and function of extracellular vesicles (EVs)—specialized membrane-bound nanocarriers for intercellular communication—suggests that they might also serve as optimal delivery systems of therapeutics. In addition to carrying proteins, lipids, DNA and different forms of RNAs, EVs can be engineered to deliver specific bioactive molecules to target cells. Exploitation of their molecular composition and physical properties, together with improvement in bio-techniques to modify their content are critical issues to target them to specific cells/tissues/organs. Here, we will discuss the current developments in the field of animal and plant-derived EVs toward their potential use for delivery of therapeutic agents in different pathological conditions, with a special focus on cancer. View Full-Text
Keywords: drug delivery; liposomes; extracellular vesicles; target therapies; plant-derived extracellular vesicles drug delivery; liposomes; extracellular vesicles; target therapies; plant-derived extracellular vesicles

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Raimondo, S.; Giavaresi, G.; Lorico, A.; Alessandro, R. Extracellular Vesicles as Biological Shuttles for Targeted Therapies. Int. J. Mol. Sci. 2019, 20, 1848.

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