Special Issue "Curcumin in Health and Disease"
Deadline for manuscript submissions: closed (25 January 2019).
A printed edition of this Special Issue is available here.
Interests: molecular oncology; prevention; curcumin; biomolecular research; cellular biology; plant derived bioactives; biomarkers
Special Issues and Collections in MDPI journals
The plant-derived polyphenol Curcumin has been used in health and disease for thousands of years and its therapeutic effects have been successfully utilized in Ayurvedic and Traditional Chinese Medicine in order to treat inflammatory diseases. Current results from modern biomolecular research reveal the modulatory effects of Curcumin on a variety of signal transduction pathways associated with inflammation and cancer. In this context, anti-oxidant, anti-inflammatory, anti-tumorigenic, and even anti-metastatic activities are discussed. On the cellular level, reduced activity of several transcription factors, such as NFkB or AP-1 and suppression of inflammatory cytokines, matrix degrading enzymes, metastasis related genes and even microRNAs are reported. On functional levels, these molecular effects translate into reduced proliferative, invasive and metastatic capacity, as well as induced tumor cell apoptosis. All these effects have been observed not only in vitro but also in animal models. In combination with anti-neoplastic drugs like taxols or kinase inhibitors or radiation therapy, Curcumin potentiates their therapeuthic power and shows even protective effects against undesired side effects.
Natural plant-derived compounds like Curcumin have one significant advantage: They largely do not exert side effects. This feature qualifies Curcumin for primary prevention, in healthy persons with a predisposition to cancer, arteriosclerosis or chronic inflammatory dieseases. Nonetheless, Curcumin is considered "safe", however, toxic effects especially concerning high dosages, long-term intake and pharmacological interactions with other compounds have to be tested.
This Special Issue examines in detail, and provides an update on, the molecular targets, protective effects, and modes of action of natural plant-derived compounds and their roles in the prevention and treatment of human diseases.
Prof. Dr. Beatrice E. Bachmeier
Manuscript Submission Information
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- natural compounds
- molecular pathways
- combination therapy
- toxicity / safety