Ceramide

Dear Colleagues,

The emergence of ceramide as an important mediator in a variety of cellular processes and diseases has stimulated extensive and all-encompassing research.

Ceramide originates from three sources. Increases in sphingomyelin hydrolysis by activation of sphingomyelinases; increased de novo synthesis to activation of serine palmitoyl transferase and/or ceramide synthase; and increased sphingosine-1-phosphate hydrolysis by sphingosine-1-phosphatase to produce sphingosine followed by ceramide synthesis by ceramide synthase.

Ceramide generation in response, for example, to cellular stress is known to mediate cell death through various mechanisms, including induction of apoptosis, necroptosis, autophagy and ER stress. However, the role of ceramide varies widely depending on cell and tissue type, its subcellular localization, and the availability of downstream targets.

This Special Issue will discuss the recent advances in the field of ceramide mediated cell signaling. Thereby contributing to our knowledge on how the rapid metabolic conversions, trafficking, and signaling roles of ceramide come into play in both physiological and pathological conditions.

Dr. Jean-Pierre Jaffrézou
Guest Editor

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