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Special Issue "Ceramide"
Deadline for manuscript submissions: closed (31 March 2019).
The emergence of ceramide as an important mediator in a variety of cellular processes and diseases has stimulated extensive and all-encompassing research.
Ceramide originates from three sources. Increases in sphingomyelin hydrolysis by activation of sphingomyelinases; increased de novo synthesis to activation of serine palmitoyl transferase and/or ceramide synthase; and increased sphingosine-1-phosphate hydrolysis by sphingosine-1-phosphatase to produce sphingosine followed by ceramide synthesis by ceramide synthase.
Ceramide generation in response, for example, to cellular stress is known to mediate cell death through various mechanisms, including induction of apoptosis, necroptosis, autophagy and ER stress. However, the role of ceramide varies widely depending on cell and tissue type, its subcellular localization, and the availability of downstream targets.
This Special Issue will discuss the recent advances in the field of ceramide mediated cell signaling. Thereby contributing to our knowledge on how the rapid metabolic conversions, trafficking, and signaling roles of ceramide come into play in both physiological and pathological conditions.
Dr. Jean-Pierre Jaffrézou
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- ceramide synthase
- sphingosine 1-phosphate
- cell death
- metabolic disorder