Special Issue "Bone Development and Regeneration"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 January 2021.
Interests: Musculoskeletal regeneration, Bone development and homeostasis, Mesenchymal stem cell differentiation, Osteoblastic differentiation, Epigenetics
Bone is a fascinating tissue conferring structural body support, mechanical integrity, and organ protection. A more holistic perspective accommodates bone as an integral organ that together with other tissues not only regulates mineral homeostasis and maintains the hematopoietic niche but also acts as an endocrine organ to contribute and regulate numerous metabolic processes that are independent of mineral metabolism.
Bone formation is orchestrated by multiple stimuli and processes and based on their embryological origin, ossification of collagenous tissues is regulated by different paths. Compared to other musculoskeletal tissues, bone has a high regenerative potential, with the skeleton being fully remodeled multiple times throughout the human lifespan. However, with a continuous extension of live expectancy, aging-related bone issues and pathologies become more prominent, which negatively impacts the quality of life of an increasing number of individuals.
While several mechanisms and pathways like the WNT, BMP2 or PTH signaling pathway have been thoroughly studied over the last few decades, new scientific capabilities and perspectives allow for a more integrative and comprehensive view on bone development and bone regeneration. With the revolutionary rise of the -omics field and the latest advances in cell lineage tracing models and single cell analysis, new molecular mechanisms are being elucidated and novel important players are being recognized. For example, our understanding of epigenetic processes or metabolites that control bone integrity is growing at a rapid pace. In concert with the progress made recently in the development and design of new scaffolds and biomaterials, all these advances generate novel and alternative approaches to target bone regeneration and are under investigation with the potential to increase the quality of life for many.
This Special Issue of IJMS provides a platform for high-quality publications elucidating novel insights on bone development and/or presenting new molecular and conceptual approaches for the manipulation of osteogenesis and bone regeneration, as well as bone homeostasis. This will generate a representative picture of the latest advances in bone research and serve as a road map for where the bone field is headed.
Dr. Roman Thaler
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- mesenchymal stem cell
- cell differentiation
- integrative analysis