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New Types of Antimicrobial Biocides: 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: closed (15 January 2025) | Viewed by 1529

Special Issue Editor

Special Issue Information

Dear Colleagues,

Biocides is the general name for substances that have the ability to fight harmful organisms. The word “biocide” comes from the Latin words “bio” (“life”) and “cidere” (“kill”).

Biocides are widely used in healthcare and various industries to combat infection and microbial contamination. Ineffective surface disinfection can result in the persistence of pathogenic microorganisms on inanimate surfaces, often contributing to the transmission of infectious agents. The excessive use of biocides results in significant environmental and economic impact. The misuse of these substances and the escalation of doses (as a means of overcoming microbial resistance) poses a threat to public health.

In an era where infection control is seen as a key method of preventing the transmission of antimicrobial-resistant microorganisms, the effectiveness of biocides must be maintained. Therefore, the search for new active substances should take into account the importance of strategies to avoid the cross-resistance of microorganisms to biocides and antibiotics.

Prof. Dr. Irena Maliszewska
Guest Editor

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Keywords

  • biocides
  • pathogen
  • cross-resistance
  • infection

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Published Papers (1 paper)

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Research

21 pages, 2016 KiB  
Article
In Vitro and In Vivo Translational Insights into the Intraoperative Use of Antiseptics and Lavage Solutions Against Microorganisms Causing Orthopedic Infections
by Bartłomiej Dudek, Malwina Brożyna, Michał Karoluk, Mariusz Frankiewicz, Paweł Migdał, Konrad Szustakiewicz, Tomasz Matys, Adrian Wiater and Adam Junka
Int. J. Mol. Sci. 2024, 25(23), 12720; https://doi.org/10.3390/ijms252312720 - 26 Nov 2024
Viewed by 1155
Abstract
The growing antibiotic resistance of microorganisms causing postoperative infections following orthopedic surgeries underscores the urgent need for localized antiseptic and lavage delivery systems to enhance infection control. This study evaluates the in vitro effectiveness of antiseptic and lavage solutions—including polyhexanide, povidone–iodine, low-concentrated hypochlorite, [...] Read more.
The growing antibiotic resistance of microorganisms causing postoperative infections following orthopedic surgeries underscores the urgent need for localized antiseptic and lavage delivery systems to enhance infection control. This study evaluates the in vitro effectiveness of antiseptic and lavage solutions—including polyhexanide, povidone–iodine, low-concentrated hypochlorite, Ringer’s solution, and saline—against Staphylococcus epidermidis, Staphylococcus aureus MRSA, Cutibacterium acnes, Corynebacterium amycolatum, Pseudomonas aeruginosa, and Candida albicans. Using microplate models (Minimum Inhibitory Concentration, Minimum Biofilm Eradication Concentration, and Biofilm-Oriented Antiseptic Test assays), flow-based models (Bioflux system), and surfaces relevant to orthopedic implants (e.g., stainless steel disks/screws, Co-Cr-Mo, Ti-Al-Nb orthopedic alloys, and ultra-high-molecular-weight polyethylene), as well as a bio-nano-cellulose scaffold representing tissue, we assessed the solutions’ activity. The cytotoxicity of the solutions was evaluated using osteoblast and keratinocyte cell lines, with additional in vivo insights gained through the Galleria mellonella larval model. The results show that polyhexanide-based solutions outperformed povidone–iodine in biofilm eradication in most tests applied, particularly on complex surfaces, whereas iodine demonstrated higher cytotoxicity in applied in vitro and in vivo tests. Low-concentration hypochlorite solutions exhibited minimal antibiofilm activity but also showed no cytotoxicity in cell line and G. mellonella larval models. These findings highlight the importance of careful antiseptic selection and rinsing protocols to balance infection control efficacy with tissue compatibility in orthopedic applications. Full article
(This article belongs to the Special Issue New Types of Antimicrobial Biocides: 2nd Edition)
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