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Plant Phenolic Compounds: Therapeutic Potential and Action Mechanisms
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Plant Phenolic Compounds: Therapeutic Potential and Action Mechanisms

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (25 November 2023) | Viewed by 2673

Special Issue Editors

Dr. Lucía Melguizo-Rodríguez

E-Mail Website
Guest Editor
Department of Nursing, Faculty of Health Sciences, University of Granada, 18016 Granada, Spain
Interests: olive oil; phenolic compounds; wound healing; antimicrobial properties; cell biology
Dr. Olga García-Martínez

E-Mail Website
Guest Editor
Department of Nursing, Faculty of Health Sciences, University of Granada, 18016 Granada, Spain
Interests: olive oil; phenolic compounds; wound healing; antimicrobial properties; soft tissue; bone tissue

Special Issue Information

Dear Colleagues,

The present Special Issue is entitled “Plant Phenolic Compounds: Therapeutic Potential and Action Mechanisms”. Phenolic compounds have their origin in the plant world, being one of the main secondary metabolites of plants. These bioactive compounds are widely known for their antioxidant, estrogenic, and antimicrobial properties. For this reason, there is an increasing interest, at present, in understanding the potential impact of these molecules on human health. The contributions to this Special Issue will focus on different aspects of plant phenols and polyphenols, whether they are pure compounds or present in certain foods, including their therapeutic potential at different levels of the organism, their role in disease prevention, as well as the elucidation of the mechanisms of action involved in their beneficial effects on human health. This Special Issue also invites submissions of studies that establish the preventive effects of polyphenols for human and animal models. Both original papers and review articles describing the therapeutic potential of phenolic compounds are welcome.

Dr. Lucía Melguizo-Rodríguez
Dr. Olga García-Martínez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polyphenols
  • polyphenolic derivates
  • dietary supplements
  • human health
  • biological activities
  • antioxidant
  • antimicrobial
  • cardiovascular disease
  • diabetes
  • cancer
  • mechanism of action

Published Papers (2 papers)

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Research

18 pages, 3117 KiB  
Article
Ethyl Acetate Fractions of Tectona Grandis Crude Extract Modulate Glucose Absorption and Uptake as Well as Antihyperglycemic Potential in Fructose–Streptozotocin-Induced Diabetic Rats
by Olakunle Sanni, Pilani Nkomozepi and Md. Shahidul Islam
Int. J. Mol. Sci. 2024, 25(1), 28; https://doi.org/10.3390/ijms25010028 - 19 Dec 2023
Viewed by 872
Abstract
Type 2 diabetes (T2D) is a global health challenge with increased morbidity and mortality rates yearly. Herbal medicine has provided an alternative approach to treating T2D with limited access to formal healthcare. Tectona grandis is being used traditionally in the treatment of diabetes. [...] Read more.
Type 2 diabetes (T2D) is a global health challenge with increased morbidity and mortality rates yearly. Herbal medicine has provided an alternative approach to treating T2D with limited access to formal healthcare. Tectona grandis is being used traditionally in the treatment of diabetes. The present study investigated the antidiabetic potential of T. grandis leaves in different solvent extractions, and the crude extract that demonstrated the best activity was further fractionated through solvent–solvent partitioning. The ethyl acetate fraction of the ethanol crude extract showed the best antidiabetic activity in inhibiting α-glucosidase, delaying glucose absorption at the small intestine’s lumen, and enhancing the muscle’s postprandial glucose uptake. The ethyl acetate fraction was further elucidated for its ability to reduce hyperglycemia in diabetic rats. The ethyl acetate fraction significantly reduced high blood glucose levels in diabetic rats with concomitant modulation in stimulated insulin secretions through improved pancreatic β-cell function, insulin sensitivity by increasing liver glycogen content, and reduced elevated levels of liver glucose-6-phosphatase activity. These activities could be attributed to the phytochemical constituents of the plant. Full article
(This article belongs to the Special Issue Plant Phenolic Compounds: Therapeutic Potential and Action Mechanisms)
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16 pages, 1025 KiB  
Article
Src Tyrosine Kinase Inhibitory and Antioxidant Activity of Black Chokeberry and Bilberry Fruit Extracts Rich in Chlorogenic Acid
by Sanda Vladimir-Knežević, Maja Bival Štefan, Biljana Blažeković, Dubravko Jelić, Tea Petković, Marta Mandić, Ekaterina Šprajc and Sandy Lovković
Int. J. Mol. Sci. 2023, 24(21), 15512; https://doi.org/10.3390/ijms242115512 - 24 Oct 2023
Viewed by 1379
Abstract
Edible berries such as the fruits of black chokeberry (Aronia melanocarpa (Michx.) Elliott) and bilberry (Vaccinium myrtillus L.) are considered to be rich in phenolic compounds, which are nowadays attracting great interest due to their promising health benefits. The main objective [...] Read more.
Edible berries such as the fruits of black chokeberry (Aronia melanocarpa (Michx.) Elliott) and bilberry (Vaccinium myrtillus L.) are considered to be rich in phenolic compounds, which are nowadays attracting great interest due to their promising health benefits. The main objective of our study was to investigate, for the first time, their inhibitory properties on Src tyrosine kinase activity, as this enzyme plays an important role in multiple cellular processes and is activated in both cancer and inflammatory cells. In hydroethanolic fruit extracts, 5.0–5.9% of total polyphenols were determined spectrophotometrically, including high amounts of hydroxycinnamic acid derivatives. HPLC analysis revealed that the black chokeberry and bilberry extracts contained 2.05 mg/g and 2.54 mg/g of chlorogenic acid, respectively. Using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay, the extracts studied were found to have comparable inhibitory effects on Src tyrosine kinase, with IC50 values of 366 µg/mL and 369 µg/mL, respectively. The results also indicated that chlorogenic acid contributes significantly to the observed effect. In addition, both fruit extracts exhibited antioxidant activity by scavenging DPPH and NO radicals with SC50 values of 153–352 µg/mL. Our study suggested that black chokeberry and bilberry fruits may be beneficial in cancer and other inflammation-related diseases. Full article
(This article belongs to the Special Issue Plant Phenolic Compounds: Therapeutic Potential and Action Mechanisms)
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