Ischemia Reperfusion Injury: A Cell Signaling Crossroads and Therapeutics

Dear Colleagues, 

Ischemia–reperfusion injury (IRI) is inherent to surgery and organ resection and transplantation (TX). The cumulative damage due to ischemia and reperfusion associated with organ transplantation compromises the viability of the organ and its successful transplantation outcome. The present knowledge of underlying IRI pathophysiological mechanisms reveals a complex cell signaling crossroads that makes further therapeutic strategies difficult and justifies the in-depth investigation of the cell signaling pathways involved in IRI to prevent its adverse consequences more effectively and improve organ transplantation outcomes.

The advances in the study of IRI pathophysiology mechanisms are poor when compared to the development of immunosuppressive strategies in TX. For this reason, and continuing with the core idea of previous Special Issues, it is necessary to explore new insights into the molecular pathways involved in the complex pathophysiology of IRI, covering different perspectives, including different organs (heart, liver, kidney, pancreas, small intestine), with a special emphasis on the underlying mechanisms, including but not limited to the involvement of inflammatory mediators, mitochondrial dysfunction, apoptosis, and other potential markers associated with IRI.

This Special Issue calls for original research, full reviews, and perspectives that address the progress and current knowledge on the pathophysiological mechanisms of IRI in different organs. This includes protective graft preservation strategies with MP, surgical intervention, ischemic preconditioning/postconditioning, and pharmacological strategies including clinical and experimental settings. We welcome studies on the pathophysiological mechanisms involved in warm and cold ischemia and the inherent reperfusion and any strategy aimed at the prevention of IRI. Contributions are not limited to the fields that are mentioned in the keywords.

Prof. Dr. Joan Roselló-Catafau
Prof. Dr. René Adam
Dr. Teresa Carbonell Camós
Guest Editors

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