Inflammatory Bowel Disease’s Journey: From Metabolism and Immunity to New Therapeutic Horizons

Dear Colleagues,

Inflammatory bowel diseases (IBD) encompassing two major forms, Crohn's disease (CD) and ulcerative colitis (UC), are immune-mediated disorders with a complex genetic background and involve constantly changing endogenous and environmental factors.

The comprehension of molecular actors, and the implementation of multi-omics technologies, as well as the pivotal role of the gut microbiome, are compelling the research community to reevaluate the knowledge and molecular processes. As our comprehension of the pathogenic mechanisms of inflammatory bowel disease (IBD) increases, the therapeutic armamentarium for its treatment can expand, and novel target therapies join the treatment pipeline.

In the present Research Topic, we encourage experienced colleagues to submit original research articles, case studies, and review articles regarding molecular and/or metabolic features in order to identify novel biomarkers, and novel diagnostic tools for detection and monitoring, to improve the medical treatment of UC and CD, to manage concomitant extra-intestinal manifestations and to identify novel therapeutics approaches.

Dr. Rocco Spagnuolo
Dr. Daniela Pugliese
Guest Editors

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