Molecular Pathophysiology of Dermatitis: Mechanisms and Therapeutic Perspectives
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 98
Special Issue Editor
Interests: allergic disease; human immunology; pathways of intercellular communication and antigen presentation and induction of immune tolerance; natural products; osthole (OST)
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Dermatitis is now recognised as a complex, chronic inflammatory skin disease that is influenced by genetic, immunological, and environmental factors. It is characterised by a disturbed skin barrier, which leads to increased transepidermal water loss (TEWL) and increased susceptibility to infections and allergens. Atopic dermatitis (AD) is also characterised by hypersensitivity in the immune system leading to increased keratinocyte (KC) proliferation, acanthosis, and an enhanced inflammatory response driven by type-2 T helper cells (Th2). Immunological dysfunction in AD involves abnormal innate, adaptive, and humoral immunity, possibly influenced by epigenetic alterations. AD is associated with a predisposition to CD4+ Th2 cell differentiation and increased immunoglobulin E (IgE) levels, leading to hypersensitivity and associated diseases, such as asthma. Barrier dysfunction in AD is often associated with mutations in the filaggrin (FLG) gene, which disrupt the integrity of the skin and predisposes individuals to allergic sensitisation and elevated serum IgE levels. About 80% of AD patients have these elevated IgE levels, which correlate with the severity of the disease.
Fortunately, research in the field of dermatitis is making steady progress. Unfortunately, however, many questions remain unanswered. Among the most important are the following: What are the main pathological/immunological factors that cause skin dermatitis? What changes in protein profiles and gene expression are observed in skin diseases? Can these changes be inhibited via stimulation with immunological factors? What alternative therapies are currently being considered to inhibit dermatitis?
This Special Issue will focus on the molecular role, which is not yet fully understood, and summarise what is known about new or alternative therapeutic options and the inhibition of immune hyperreactivity in dermatosis, from mechanisms to therapy. We welcome articles that focus on understanding the immunological aspects observed in skin atopy. These can be original research articles or reviews. Research areas include, but are not limited to, psoriasis, atopic dermatitis, autoinflammatory skin diseases, and allergic contact dermatitis.
Dr. Natalia Karolina Galińska
Guest Editor
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Keywords
- immune-mediated skin diseases
- molecular mechanism of dermatitis
- new therapeutic substances and treatment techniques
- dermatitis
- skin diseases
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