Mechanisms of Vascular Calcification
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (30 July 2020) | Viewed by 102144
Special Issue Editor
Interests: vascular calcification; vascular smooth muscle cells; phosphate homeostasis; chronic kidney disease; vascular stiffness and fibrosis; cardiac remodeling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Ectopic calcifications in cardiovascular tissues are highly prevalent and closely related to cardiovascular events and mortality. Yet, no broadly applicable treatment option is available to prevent the onset of cardiovascular calcifications.
Physiologically, the fine-tuned balance between calcification inhibitors and calcium/phosphate prevents ectopic calcifications. This balance is disturbed during various pathological conditions, and ectopic calcifications may develop as consequence of an active process. Calcifying stimuli induce a phenotypical transdifferentiation of vascular smooth muscle cells, fibroblast-like cells, and endothelial cells into cells with osteoblast-like and chondroblast-like characteristics. These transdifferentiated cells can exert various procalcific effects, such as impairment of calcification inhibitors, matrix remodeling, and calcifying vesicle release. However, the complex mechanisms involved in the process of cardiovascular calcification are incompletely understood. Further research is required to advance our understanding in this calcification process and to develop new therapeutic concepts.
This Special Issue of IJMS aims to cover new insights into the mechanisms of ectopic cardiovascular calcifications. This includes all relevant observations on the development and consequences of intimal, medial, and valvular calcifications, as well as new methodological approaches.
Original investigations in preclinical models and translational human studies as well as review manuscripts are cordially invited for this Special Issue.
Prof. Dr. Jakob Voelkl
Guest Editor
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Keywords
- Vascular calcification
- Valvular calcification
- Vascular smooth muscle cells
- Endothelial cells
- Procalcific signaling molecules
- Calcification inhibitors
- Phosphate/calcium homeostasis
- Pro-/anticalcific signaling pathways
- Regulation of calcium–phosphate deposition
- Consequences of cardiovascular calcification
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