Photodynamic Therapy and Photodetection, Third Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 16
Special Issue Editor
Special Issue Information
Dear Colleagues,
Photodynamic therapy (PDT) is a combination of light with a lesion-localising photosensitiser and oxygen present in a lesion, leading to photochemical and photobiological reactions that result in irreversible photodamage to the lesion. Photodetection (PD) is based on fluorescence-spectroscopic and imaging techniques, demarcating a lesion from surrounding healthy tissues. The specific fluorescence in the lesion is induced by a light source with a suitable wavelength, in most cases with prior administration of a photosensitiser or its precursor. Although the phenomena of PDT and PD were discovered more than 100 years ago, the results from preclinical and clinical studies conducted worldwide during the past >45 years have established modern PDT and PD as clinical modalities for a number of malignant and non-malignant disorders. Photochemical internalization, a PDT-based new technology, is used for the efficient delivery of endosome-trapped molecules into the cytosol of cells. Targeted PDT and nanotechnology have recently contributed to the development of PDT and PD. As yet, no universal mechanism of action for PDT has been described; it may have different mechanisms depending on the type of a lesion treated, photosensitiser used, and/or light dose applied. This Special Issue will update the scientific literature regarding the current status of PDT and PD, with an emphasis on the mechanism of molecular action involved.
Dr. Sabrina Cavin
Guest Editor
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Keywords
- photodynamic therapy (PDT)
- photodetection (PD)
- photosensitiser photochemical internalization (PCI)
- quantum dots
- nanoparticles
- nanotechnology
- targeted therapy
- immunotherapy
- vaccines
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