Cellular and Molecular Biology of Glial Cells
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (20 June 2025) | Viewed by 1500
Special Issue Editor
2. Department Neuroscience Program, Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
3. Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
4. Cancer Center at Illinois and Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
Interests: glial cell; neuroinflammation; pathways
Special Issue Information
Dear Colleagues,
It is well-established that glial cells play an important role in providing trophic support for neurons, improve conduction velocity, lower energy demand for action potential generation and generally function to maintain central nervous system (CNS) homeostasis. It has also been appreciated that aberrant responses by glia, as occurs during neuroinflammation, systemic inflammation, neurodegeneration and/or neurological disorders, likely contribute to altered homeostasis, neurotoxicity, pathology and disease progression. However, the intercellular interactions between glial cells as well as the cellular and molecular mechanisms that facilitate homeostatic maintenance of the CNS during health, or disease states brought on by inflammation, traumatic injury, cancer and/or metabolic dysfunction, have not yet been fully elucidated. For example, recent reports have ascribed novel cellular response phenotypes to glial subsets, including phagocytosis by astrocytes, cytokine/chemokine production and antigen presentation by oligodendrocytes as well as plasticity in myelination during adulthood. Moreover, it is becoming clear that metabolic flux of glial cells is subject to internal and external stimuli. These new areas of study are poised to shape our understanding of how glia function during both homeostatic and non-homeostatic conditions. The aim of this Special Issue entitled “Cellular and Molecular Biology of Glial Cells” is to enrich our knowledge on the fundamental roles that glia, such as astrocytes, oligodendrocytes and microglia have in maintaining homeostasis as well as illuminate their contribution towards pathology.
Dr. Andrew J. Steelman
Guest Editor
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Keywords
- microglia
- astrocytes
- oligodendrocytes
- metabolism
- homeostasis
- neuroinflammation
- pathology
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