Molecular Research on Type 1 Diabetes and Its Complications

Dear Colleagues,

Type 1 diabetes (T1D) is characterized by autoimmune destruction of insulin-producing beta cells of the pancreatic islets, leading to permanent impairment of glucose metabolism. Although the exact pathogenesis of T1D is unknown, several gene loci involved in the disease outbreak have been identified. The standard of management remains multiple daily insulin injections or continuous subcutaneous insulin infusion in combination with blood glucose monitoring. Despite advances in insulin therapies, patients still suffer acute and chronic micro- and macrovascular diabetic complications, including ketoacidosis, neuropathy, nephropathy, retinopathy, cardiovascular disease, and significant challenges remain unsolved. There are no effective treatments targeting the prevention or delay of T1D by modulating the underlying autoimmune issues.

In this Special Issue of IJMS, we will present an up-to-date overview of molecular research on the pathogenesis, identification of biomarkers for preclinical diagnosis, and potential future treatments for T1D and its complications.

Topics of interest include the following:

Molecular research on

• The pathogenesis of type 1 diabetes—the role of the environment;
• The pathogenesis of type 1 diabetes—the role of genes;
• The pathogenesis of acute type 1 diabetes complications;
• The pathogenesis of chronic type 1 diabetes complications;
• The preclinical diagnosis of type 1 diabetes;
• The early identification of type 1 diabetes complications;
• Insulin analogs and transdermal delivery;
• Immunomodulatory treatment of type 1 diabetes;
• Treatment of micro-vascular type 1 diabetes complications;
• Treatment of macro-vascular type 1 diabetes complications.

Prof. Dr. Assimina Galli-Tsinopoulou
Prof. Dr. Athanasios Christoforidis
Dr. Eleni P Kotanidou
Dr. Styliani Giza
Guest Editors

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