Special Issue "Molecular Research on Type 1 Diabetes and Its Complications"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 6334
Interests: glucose metabolism; type 1 diabetes mellitus; hyperglycaemia; diabetic complications; growth; short stature; growth hormone deficiency; overgrowth syndromes; obesity; prediabetes; impaired glucose tolerance; type 2 diabetes mellitus; hyperinsulinaemia; insulin resistance; metabolic syndrome; retarded puberty; precocious puberty; metabolic bone diseases; thyroid disorders; adrenal disorders; endocrine late effects in childhood cancer survivors
Interests: type 1 diabetes mellitus; puberty; growth; bone health
Interests: glucose metabolism; type 1 diabetes mellitus; hyperglycaemia; diabetic complications; growth; short stature; obesity; prediabetes; impaired glucose tolerance; type 2 diabetes mellitus; hyperinsulinaemia; insulin resistance; endocrine late effects in childhood cancer survivors
Interests: glucose metabolism; type 1 diabetes mellitus; hyperglycaemia; diabetic complications; obesity; prediabetes; impaired glucose tolerance; type 2 diabetes mellitus; hyperinsulinaemia; insulin resistance; metabolic syndrome; thyroid disorders
Type 1 diabetes (T1D) is characterized by autoimmune destruction of insulin-producing beta cells of the pancreatic islets, leading to permanent impairment of glucose metabolism. Although the exact pathogenesis of T1D is unknown, several gene loci involved in the disease outbreak have been identified. The standard of management remains multiple daily insulin injections or continuous subcutaneous insulin infusion in combination with blood glucose monitoring. Despite advances in insulin therapies, patients still suffer acute and chronic micro- and macrovascular diabetic complications, including ketoacidosis, neuropathy, nephropathy, retinopathy, cardiovascular disease, and significant challenges remain unsolved. There are no effective treatments targeting the prevention or delay of T1D by modulating the underlying autoimmune issues.
In this Special Issue of IJMS, we will present an up-to-date overview of molecular research on the pathogenesis, identification of biomarkers for preclinical diagnosis, and potential future treatments for T1D and its complications.
Topics of interest include the following:
Molecular research on
- The pathogenesis of type 1 diabetes—the role of the environment;
- The pathogenesis of type 1 diabetes—the role of genes;
- The pathogenesis of acute type 1 diabetes complications;
- The pathogenesis of chronic type 1 diabetes complications;
- The preclinical diagnosis of type 1 diabetes;
- The early identification of type 1 diabetes complications;
- Insulin analogs and transdermal delivery;
- Immunomodulatory treatment of type 1 diabetes;
- Treatment of micro-vascular type 1 diabetes complications;
- Treatment of macro-vascular type 1 diabetes complications.
Prof. Dr. Assimina Galli-Tsinopoulou
Prof. Dr. Athanasios Christoforidis
Dr. Eleni P Kotanidou
Dr. Styliani Giza
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