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Notch Signaling in Health and Disease 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (28 June 2024) | Viewed by 4109

Special Issue Editors


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Guest Editor
Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”, Via dell’Istria 65/1, 34137 Trieste, Italy
Interests: cell biology; apoptosis; keratinocytes; keratinocytes differentiation; keratinocytes proliferation; notch signaling; dermatology diseases
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Special Issue Information

Dear Colleagues, 

This Special Issue is a continuation of our previous Special Issue “Notch Signaling in Health and Disease”.

Notch signaling plays a crucial role in various cellular processes, such as proliferation, differentiation, migration, cellular fate, and death, during both normal development and in those with pathological conditions.

Notch signaling controls the induction of keratinocyte growth, promotes the activation of the differentiation program, and is also involved in the regulation of inflammatory responses. Alterations and hyper- or hypo-activation in Notch signaling molecules and in their target genes can induce failure in the regulation of keratinocyte functions, which, in turn, produces skin diseases.

The pathogenetic role of the Notch pathway in skin diseases is not currently fully understood. In recent years, attention has been focused on the correlation between Notch signaling and skin diseases; Notch signaling alterations have recently been reported for the following five human skin diseases, suggesting the involvement of Notch in their pathogenesis: hidradenitis suppurativa, Dowling–Degos disease, Adams–Oliver syndrome, psoriasis, and atopic dermatitis.

This Special Issue is dedicated to the role of Notch signaling in health and skin diseases. Areas of particular interest include but are not limited to defects in keratinocytes and skin health and diseases, autoinflammatory keratinization diseases, and Notch signaling regulation in health and skin diseases.

Dr. Paola Maura Ticarico
Prof. Dr. Sergio Crovella
Guest Editors

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Keywords

  • dermatological diseases
  • Notch signaling
  • keratinocytes
  • inflammation
  • autoinflammation
  • differentiation
  • keratinization
  • proliferation

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Related Special Issue

Published Papers (3 papers)

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Review

17 pages, 4991 KiB  
Review
NOTCH3 and Pulmonary Arterial Hypertension
by Nolan M. Winicki, Cristian Puerta, Casandra E. Besse, Yu Zhang and Patricia A. Thistlethwaite
Int. J. Mol. Sci. 2024, 25(11), 6248; https://doi.org/10.3390/ijms25116248 - 6 Jun 2024
Viewed by 820
Abstract
NOTCH3 receptor signaling has been linked to the regulation of smooth muscle cell proliferation and the maintenance of smooth muscle cells in an undifferentiated state. Pulmonary arterial hypertension (World Health Organization Group 1 idiopathic disease: PAH) is a fatal disease characterized clinically by [...] Read more.
NOTCH3 receptor signaling has been linked to the regulation of smooth muscle cell proliferation and the maintenance of smooth muscle cells in an undifferentiated state. Pulmonary arterial hypertension (World Health Organization Group 1 idiopathic disease: PAH) is a fatal disease characterized clinically by elevated pulmonary vascular resistance caused by extensive vascular smooth muscle cell proliferation, perivascular inflammation, and asymmetric neointimal hyperplasia in precapillary pulmonary arteries. In this review, a detailed overview of the specific role of NOTCH3 signaling in PAH, including its mechanisms of activation by a select ligand, downstream signaling effectors, and physiologic effects within the pulmonary vascular tree, is provided. Animal models showing the importance of the NOTCH3 pathway in clinical PAH will be discussed. New drugs and biologics that inhibit NOTCH3 signaling and reverse this deadly disease are highlighted. Full article
(This article belongs to the Special Issue Notch Signaling in Health and Disease 2.0)
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17 pages, 1371 KiB  
Review
Notch Signaling: An Emerging Paradigm in the Pathogenesis of Reproductive Disorders and Diverse Pathological Conditions
by Sreesada Parambath, Nikhil Raj Selvraj, Parvathy Venugopal and Rajaguru Aradhya
Int. J. Mol. Sci. 2024, 25(10), 5423; https://doi.org/10.3390/ijms25105423 - 16 May 2024
Viewed by 1186
Abstract
The highly conserved Notch pathway, a pillar of juxtacrine signaling, orchestrates intricate intercellular communication, governing diverse developmental and homeostatic processes through a tightly regulated cascade of proteolytic cleavages. This pathway, culminating in the migration of the Notch intracellular domain (NICD) to the nucleus [...] Read more.
The highly conserved Notch pathway, a pillar of juxtacrine signaling, orchestrates intricate intercellular communication, governing diverse developmental and homeostatic processes through a tightly regulated cascade of proteolytic cleavages. This pathway, culminating in the migration of the Notch intracellular domain (NICD) to the nucleus and the subsequent activation of downstream target genes, exerts a profound influence on a plethora of molecular processes, including cell cycle progression, lineage specification, cell–cell adhesion, and fate determination. Accumulating evidence underscores the pivotal role of Notch dysregulation, encompassing both gain and loss-of-function mutations, in the pathogenesis of numerous human diseases. This review delves deep into the multifaceted roles of Notch signaling in cellular dynamics, encompassing proliferation, differentiation, polarity maintenance, epithelial–mesenchymal transition (EMT), tissue regeneration/remodeling, and its intricate interplay with other signaling pathways. We then focus on the emerging landscape of Notch aberrations in gynecological pathologies predisposing individuals to infertility. By highlighting the exquisite conservation of Notch signaling in Drosophila and its power as a model organism, we pave the way for further dissection of disease mechanisms and potential therapeutic interventions through targeted modulation of this master regulatory pathway. Full article
(This article belongs to the Special Issue Notch Signaling in Health and Disease 2.0)
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17 pages, 1293 KiB  
Review
Regulation of Notch1 Signalling by Long Non-Coding RNAs in Cancers and Other Health Disorders
by Joanna Kałafut, Arkadiusz Czerwonka, Karolina Czapla, Alicja Przybyszewska-Podstawka, Justyna Magdalena Hermanowicz, Adolfo Rivero-Müller and Lidia Borkiewicz
Int. J. Mol. Sci. 2023, 24(16), 12579; https://doi.org/10.3390/ijms241612579 - 8 Aug 2023
Cited by 1 | Viewed by 1516
Abstract
Notch1 signalling plays a multifaceted role in tissue development and homeostasis. Currently, due to the pivotal role of Notch1 signalling, the relationship between NOTCH1 expression and the development of health disorders is being intensively studied. Nevertheless, Notch1 signalling is not only controlled at [...] Read more.
Notch1 signalling plays a multifaceted role in tissue development and homeostasis. Currently, due to the pivotal role of Notch1 signalling, the relationship between NOTCH1 expression and the development of health disorders is being intensively studied. Nevertheless, Notch1 signalling is not only controlled at the transcriptional level but also by a variety of post-translational events. First is the ligand-dependent mechanical activation of NOTCH receptors and then the intracellular crosstalk with other signalling molecules—among those are long non-coding RNAs (lncRNAs). In this review, we provide a detailed overview of the specific role of lncRNAs in the modulation of Notch1 signalling, from expression to activity, and their connection with the development of health disorders, especially cancers. Full article
(This article belongs to the Special Issue Notch Signaling in Health and Disease 2.0)
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